Bunion

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1		Catherine Yang	+ 481 word(s)	481	2020-12-15 07:18:06

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/bunion

A bunion, known technically as hallux valgus, is a bony bump on the side of the foot at the base of the big toe. Bunions develop slowly as pressure on the joint at the base of the big toe causes the toe to move out of place, leaning inward toward the second toe. Because this joint carries a lot of weight during activities like standing and walking, bunions can cause foot pain, stiffness, redness, and swelling. Calluses may form where the big toe and second toe rub together or on the ball of the foot. Unless they are treated, bunions get worse over time, and it may become difficult to wear regular shoes or walk without pain. Bunions can occur in one or both feet.

genetic conditions

1. Introduction

In most cases, bunions develop in adulthood. Rarely, children may be born with bunions (known as congenital hallux valgus) or develop them later in childhood (juvenile or adolescent hallux valgus).

2. Frequency

Bunions are a very common foot disorder, affecting about a third of adults in the United States. The prevalence of bunions increases with age. They are more common in women than in men, likely because of differences in foot anatomy, footwear, and genetic influences.

3. Causes

The causes of bunions are unclear, although scientists suspect that both inherited and lifestyle factors contribute to their development. Studies suggest that congenital and juvenile hallux valgus tend to be related to joint deformities with a genetic cause. Little is known about the genetic contribution to bunions that occur later in life, and no specific genes involved in the development of bunions have been identified.

For bunions that appear in adulthood, inherited factors related to the shape and structure of the foot and the way the foot moves (foot mechanics) likely influence a person's risk of developing the condition. It has long been suggested that wearing ill-fitting shoes are another significant risk factor, specifically shoes that are too tight, shoes with high heels, or shoes with a narrow toe box. Research suggests that poorly fitting shoes probably do not cause bunions, but they may make bunions develop earlier or worsen more quickly in people with an underlying susceptibility.

Other risk factors for bunions include inflammatory diseases (such as rheumatoid arthritis), osteoarthritis, and flat feet (pes planus). Bunions are also a feature of several rare genetic syndromes that affect bone development, including Chitayat syndrome and fibrodysplasia ossificans progressiva.

4. Inheritance

Bunions are a complex condition without a clear pattern of inheritance. Many affected individuals have multiple family members who are also affected. The risk of developing bunions is greater for first-degree relatives of affected individuals (such as siblings or children) as compared to the general public.

When bunions occur as part of a genetic syndrome, this feature follows the inheritance pattern of the syndrome.

5. Other Names for This Condition

bunion of great toe
hallux abductovalgus
hallux valgus
HAV
HV

References

Hannan MT, Menz HB, Jordan JM, Cupples LA, Cheng CH, Hsu YH. High heritabilityof hallux valgus and lesser toe deformities in adult men and women. ArthritisCare Res (Hoboken). 2013 Sep;65(9):1515-21. doi: 10.1002/acr.22040.
Hecht PJ, Lin TJ. Hallux valgus. Med Clin North Am. 2014 Mar;98(2):227-32.doi: 10.1016/j.mcna.2013.10.007.
Hsu YH, Liu Y, Hannan MT, Maixner W, Smith SB, Diatchenko L, Golightly YM,Menz HB, Kraus VB, Doherty M, Wilson AG, Jordan JM. Genome-wide associationmeta-analyses to identify common genetic variants associated with hallux valgusin Caucasian and African Americans. J Med Genet. 2015 Nov;52(11):762-9. doi:10.1136/jmedgenet-2015-103142.
Nix S, Smith M, Vicenzino B. Prevalence of hallux valgus in the generalpopulation: a systematic review and meta-analysis. J Foot Ankle Res. 2010 Sep27;3:21. doi: 10.1186/1757-1146-3-21.
Nix SE, Vicenzino BT, Collins NJ, Smith MD. Characteristics of foot structure and footwear associated with hallux valgus: a systematic review. OsteoarthritisCartilage. 2012 Oct;20(10):1059-74. doi: 10.1016/j.joca.2012.06.007.
Vanore JV, Christensen JC, Kravitz SR, Schuberth JM, Thomas JL, Weil LS,Zlotoff HJ, Mendicino RW, Couture SD; Clinical Practice Guideline FirstMetatarsophalangeal Joint Disorders Panel of the American College of Foot andAnkle Surgeons. Diagnosis and treatment of first metatarsophalangeal jointdisorders. Section 1: Hallux valgus. J Foot Ankle Surg. 2003May-Jun;42(3):112-23. Review. Erratum in: J Foot Ankle Surg. 2003Nov-Dec;42(6):394.

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Subjects: Genetics & Heredity

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Catherine Yang

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Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

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