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Lung Cancer

This Entry collection belongs to a new joint type of Special Issue published on Life journal and Encyclopedia platfrom, Dr. Hugo Arasanz Esteban and Dr. Paula Aldaz serve as the Guest Editors, focused original entry are welcome in this Entry collection, all entries can be published for free. You can get more information from the website of special issue about this topic: https://www.mdpi.com/journal/life/special_issues/immunotherapy_lung_cancer

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Topic review
Updated time: 22 Apr 2021
Submitted by: Elien Augustus
Definition: Currently, the only validated companion diagnostic test for first-line immunotherapy in metastatic NSCLC patients is testing for programmed death ligand 1 (PD-L1) expression in tumor tissues. However, obtaining tumor tissue can be challenging and it puts the patient at risk. Liquid biopsy offers an alternative, less invasive approach to select NSCLC patients who would benefit from immunotherapy and to monitor patients during their disease course. Liquid biopsy allows repetitive sampling, which makes it a useful tool in clinical practice.
Entry Collection : Lung Cancer
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Topic review
Updated time: 13 Apr 2021
Submitted by: Delphine Quatannens
Definition: Cancer-associated fibroblasts (CAFs) are prominent and key components of the TME in most types of solid tumors. Extensive research over the past decade revealed their ability to modulate cancer metastasis, angiogenesis, tumor mechanics, immunosuppression, and drug access through synthesis and remodeling of the extracellular matrix and production of growth factors. Thus, they are considered to impede the response to current clinical cancer therapies. Therefore, targeting CAFs to counteract these protumorigenic effects, and overcome the resistance to current therapeutic options, is an appealing and emerging strategy.
Entry Collection : Lung Cancer
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Topic review
Updated time: 09 Jul 2021
Submitted by: Yubo Shi
Definition: Lung cancer is one of the most common and malignant cancers with extremely high morbidity and mortality in both males and females. Although traditional lung cancer treatments are fast progressing, there are still limitations. Caveolin-1 (Cav-1), a main component of caveolae, participates in multiple cellular events such as immune responses, endocytosis, membrane trafficking, cellular signaling and cancer progression. It has been found tightly associated with lung cancer cell proliferation, migration, apoptosis resistance and drug resistance. In addition to this, multiple bioactive molecules have been confirmed to target Cav-1 to carry on their anti-tumor functions in lung cancers. Cav-1 can also be a predictor for lung cancer patients’ prognosis.
Entry Collection : Lung Cancer
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Topic review
Updated time: 22 Jul 2021
Submitted by: valérian dormoy
Definition: Lung cancer represents the first cause of death by cancer worldwide and remains a challenging public health issue. Hypoxia, as a relevant biomarker, has raised high expectations for clinical practice.
Entry Collection : Lung Cancer
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Topic review
Updated time: 29 Jun 2021
Submitted by: Shiau Chuen Cheah
Definition: Phytochemicals in plant-based diets are thought to contribute substantially to lung cancer prevention and may be efficacious for targeting lung cancer stem cells.
Entry Collection : Lung Cancer
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Topic review
Updated time: 23 Jun 2021
Definition: Despite significant advances, targeted therapy is greatly limited by resistance acquisition, which emerges in nearly all patients receiving treatment. As a result, identifying the molecular modulators of resistance is of great interest. Recent work has implicated protein kinase C (PKC) isozymes as mediators of drug resistance in non-small cell lung cancer (NSCLC). Importantly, previous findings on PKC have implicated this family of enzymes in both tumor-promotive and tumor-suppressive biology in various tissues. Here, we review the biological role of PKC isozymes in NSCLC through extensive analysis of cell-line-based studies to better understand the rationale for PKC inhibition.
Entry Collection : Lung Cancer
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Topic review
Updated time: 23 Jun 2021
Submitted by: Roberta Chiaraluce
Definition: Large scale genome sequencing allowed the identification of a massive number of genetic variations, whose impact on human health is still unknown. In this entry we analyze, by an in silico-based strategy, the impact of missense variants on cancer-related genes, whose effect on protein stability and function was experimentally determined. We collected a set of 164 variants from 11 proteins to analyze the impact of missense mutations at structural and functional levels, and to assess the performance of state-of-the-art methods (FoldX and Meta-SNP) for predicting protein stability change and pathogenicity.
Entry Collection : Lung Cancer
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Topic review
Updated time: 06 Apr 2021
Submitted by: Lucia Anna Muscarella
Definition: Small-cell lung cancer (SCLC) is an aggressive type of cancer with an incidence of about 15% among lung cancers and has a very poor prognosis due to its rapid development of resistance to chemo- and radiotherapies. Unlike the increase in personalized approaches to the clinical care of patients with non-small-cell lung cancer (NSCLC), clinical protocols for SCLC still mainly depend on the stage of the disease, prior therapies, and lack of specific molecular support. This approach was mainly due to the idea of SCLC as a monolithic entity with common genetic features, which was strictly linked to the lack of an adequate quantity of tissue samples in this inoperable class of patients, for the lack of a clear and comprehensive biological profile presented an obstacle.
Entry Collection : Lung Cancer
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