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Topic review
Updated time: 20 Feb 2021
Submitted by: Ramin Zibaseresht
Definition: Synthesis strategy of a terpyridine bridging ligand was explained.
Entry Collection : Molecules of the Week
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Topic review
Updated time: 07 Feb 2021
Submitted by: Susana Braga
Definition: Curcumin is a pigment with a strong yellow colour found and the main active component of Curcuma longa, a perennial Zingiberaceae plant native to southwest India, but now grown across the South and Southeast Asia, especially in China and India. It is used for centuries as a spice and currently it is viewed as a nutraceutical due to the increasing number of scientific studies demonstrating its anti-oxidant, anti-inflammatory, anti-tumoral and cancer preventive properties. Its chemical structure comprises two aromatic ring systems with o-methoxy phenol groups connected by a seven-carbon linker consisting of an α,β-unsaturated β-diketone with tautomerism when in solution.
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Topic review
Updated time: 09 Feb 2021
Submitted by: Barry V L Potter
Definition: Irosustat: (6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-3-yl) sulfamate; 6-oxo-8,9,10,11-tetrahydro-7H-cyclohepta-(c)(1)benzopyran-3-O-sulfamate; also known as STX64, 667 Coumate, BN83495, Oristusane is a tricyclic synthetic clinical drug of the aryl sulfamate ester class, designed mainly for applications in oncology as a steroid sulfatase inhibitor and has shown clinical benefit in patients.
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Others
Updated time: 08 Feb 2021
Submitted by: Yvonne Yang
Abstract: "Molecules of the Week" is a new project to collect and show the discovery of novel molecules, compounds as well as the researchers' story behind it.
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Topic review
Updated time: 29 Jan 2021
Submitted by: Keiji Hasumi
Definition: Stachybotrys microspora triprenyl phenol (SMTP) is a large family of small molecules derived from the fungus S. microspora. SMTP acts as a zymogen modulator (specifically, plasminogen modulator) that alters plasminogen conformation to enhance its binding to fibrin and subsequent fibrinolysis. Certain SMTP congeners exert anti-inflammatory effects by targeting soluble epoxide hydrolase. SMTP congeners with both plasminogen modulation activity and anti-inflammatory activity ameliorate various aspects of ischemic stroke in rodents and primates. A remarkable feature of SMTP efficacy is the suppression of hemorrhagic transformation, which is exacerbated by conventional thrombolytic treatments.
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Topic review
Updated time: 10 Feb 2021
PZT
Submitted by: Ramin Zibaseresht
Definition: The ligand, 4'-(4-(2,2,2-tris(1H-pyrazol-1-yl)ethoxymethyl)phenyl)-2,2':6',2"-terpyridine (PZT) contains a terpyridine fragment and a tris(pyrazolyl) fragment, which may allow synthetic differentiation between the tridentate binding sites as a result of the meridional and the facial coordination preferences of these groups around the octahedral metal centres. This designed bridging ligand may offer the benefits of polydentate ligands and minimisation of isomeric possibilities. The tris(pyrazolyl)methane fragment is of interest, because the coordination chemistry of such systems has also been studied. It, too, is easy to prepare, by reaction of pyrazole with chloroform, and to derivatise, for example by reaction with formaldehyde, to give a molecule, 2,2,2-tris(1H-pyrazol-1-yl)ethanol, that can be readily joined to the other binding site, a terpyridine containing synthon.
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Topic review
Updated time: 14 Mar 2021
Submitted by: Xanel Vecino
Definition: Based on their origin and composition, surfactants can be divided into three different categories: (i) synthetic surfactants; (ii) bio-based surfactants; and (iii) microbial biosurfactants. The first group is the most widespread and cost-effective. It is composed of surfactants, which are synthetically produced, using non-renewable sources, with a final structure that is different from the natural components of living cells. The second category comprises surfactants of intermediate biocompatibility, usually produced by chemical synthesis but integrating fats, sugars or amino acids obtained from renewable sources into their structure. Finally, the third group of surfactants, designated as microbial biosurfactants, are considered the most biocompatible and eco-friendly, as they are produced by living cells, mostly bacteria and yeasts, without the intermediation of organic synthesis.
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Topic review
Updated time: 20 Feb 2021
Submitted by: Ramin Zibaseresht
Definition: The ligand, 4'-(p-(1,5-bis(amino)-3-azapentane)methylphenyl)-2,2':6',2"-terpyridine (dint) contains a terpyridine fragment and a tri-amine fragment, which may allow synthetic differentiation between the tridentate binding sites at both sides and may offer the benefits of polydentate ligands and minimisation of isomeric possibilities upon coordination to metal ions.
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Topic review
Updated time: 05 May 2021
Submitted by: Carole Henique
Definition: VEGF-A (also called VEGF) is a member of the mammalian platelet-derived growth factor (PDGF) supergene family which also includes VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF).
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Topic review
Updated time: 29 Dec 2020
Submitted by: Božidar Čobeljić
Definition: Compound Name: (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium di(thiocyanato-κN) zink(II) dihydrate.
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