Topic Review
Wound-Microenvironment Engineering
In patients with comorbidities, a large number of wounds become chronic, representing an overwhelming economic burden for healthcare systems. Engineering the microenvironment is a paramount trend to activate cells and burst-healing mechanisms. The extrusion bioprinting of advanced dressings was performed with novel composite bioinks made by blending adipose decellularized extracellular matrix with plasma and human dermal fibroblasts. Rheological and microstructural assessments of the composite hydrogels supported post-printing cell viability and proliferation over time.
  • 398
  • 16 Mar 2022
Topic Review
Wound Healing Material
Dermal wound healing describes the progressive repair and recalcitrant mechanism of damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. 
  • 708
  • 22 Sep 2021
Topic Review
Work-Related Hand Eczema in Healthcare Workers
Work-related skin diseases are among the most common work-related diseases, ranking second in frequency after musculoskeletal diseases. The majority of work-related skin diseases (80–95%) are contact dermatitis, which can be both irritant and allergic in nature. Lesions are most commonly described as hand eczema and occur as a result of contact with various substances (irritants and allergens) in the workplace. The term “eczema” is generally used to describe a group of skin lesions in which the skin is itchy, dry, and inflamed. However, the term eczema usually involves a non-specific clinical picture but is commonly used in real-life and medical settings when working with patients.
  • 222
  • 07 Oct 2023
Topic Review
Wnt Signaling Pathways, Inflammation and Carcinogenesis
Wnt signaling is responsible for the regulation of different intracellular signal transduction pathways, which are essential for embryogenic development, cellular migration, polarization and differentiation as well as stem cell biology control and growth. Wnt signaling activation is related to the binding of Wnt ligands to a specific cell surface receptor which belongs to the Frizzled (Fzd) family, thus inducing the canonical (β-catenin-dependent) or non-canonical (β-catenin-independent) pathway.
  • 376
  • 31 Jan 2023
Topic Review
Vulvar Lichen Sclerosus
Vulvar lichen sclerosus (VLS) is a frequently overlooked inflammatory disorder affecting the skin and mucous membranes of the vulva. With a propensity for atrophy, severe scarring, functional impairment, and malignant evolution, VLS is a disease that recurs frequently; early diagnosis, rapid treatment, and ongoing patient follow-up are essential. Potent topical corticosteroids (TCSs) are now widely recognized as the most effective treatment for achieving remission in VLS, but considering the potential complications of long-term treatment with potent TCSs, understanding the evolution of VLS during puberty becomes particularly crucial in determining the necessity for aggressive or more conservative therapeutic interventions.
  • 106
  • 15 Jan 2024
Topic Review
Vulvar and Vaginal Melanomas
Melanomas of the skin are poorly circumscribed lesions, very frequently asymptomatic but unfortunately with a continuous growing incidence. In this landscape, one can distinguish melanomas originating in the mucous membranes and located in areas not exposed to the sun, namely the vulvo-vaginal melanomas. By contrast with cutaneous melanomas, the incidence of these types of melanomas is constant, being diagnosed in females in their late sixties. While hairy skin and glabrous skin melanomas of the vulva account for 5% of all cancers located in the vulva, melanomas of the vagina and urethra are particularly rare conditions. The location in areas less accessible to periodic inspection determines their diagnosis in advanced stages, often metastatic. 
  • 1.3K
  • 22 Sep 2021
Topic Review
Vitiligo and Mental Health
Vitiligo is a dermatosis consisting of the appearance of white discoloration patches of the skin, with a prominent pathogenetic factor represented by autoimmunity. Segmental and non-segmental are the two main forms of vitiligo, which may be recognized depending on the onset and localization: the first one is the most common and affects people with autoimmune-prone habits, whereas the non-segmental vitiligo is characterized by symmetrical white macules/patches spread over the skin surface; when untreated it is usually progressive. Macules may appear close to the mucosae (mouth, orbits, genitals, anus) and flexural areas (wrists, axillae and so on) and although they do not immediately affect physical health, they represent not only a cosmetic concern but also a risk for non-melanoma skin cancer (NMSC) development, because of the reduction of sun protection due to the lack of melanin. Different factors have been outlined as possible triggers in the development of the typical lesions, such as the tendency to develop other autoimmune diseases like Hashimoto’s thyroiditis, Addison’s disease, or alopecia areata as well as oxidative stress, trauma, sunlight exposure, and genetic factors.
  • 317
  • 29 Jan 2023
Topic Review
Vitamin D, Sun Exposure and Skin Cancer
The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. 
  • 325
  • 29 Mar 2022
Topic Review
Vitamin D and Non-Melanoma Skin Cancer
Non-melanoma skin cancers (NMSC) are the most common type of skin malignancies among humans (particularly fair-skinned populations of European descent) and its incidence rates have been on the rise globally for decades [1]. The best defined role of vitamin D in humans is in supporting the normal development and maintenance of bone tissues and in regulating calcium metabolism [7,8]. Furthermore, there is growing evidence that vitamin D plays a role in many fundamental biological processes (e.g., cell proliferation, angiogenesis, and modulation of the immune system) [9] implicated in carcinogenesis. 
  • 315
  • 26 Oct 2021
Topic Review
Visible Light as a Therapeutic Option for Pigmentary Disorders
Visible-light therapy (VLT) is commonly used for various skin diseases, mostly as a second-line option. Likewise, it plays a primary or adjunctive role in the clinical management of pigmentary disorders. In the treatment of pigmentary disorders, there are three primary types of visible-light therapies utilized: laser, intense pulsed light (IPL), and LED therapy. Each type of light has unique features and mechanisms that cater to different skin conditions and disorders.
  • 146
  • 25 Dec 2023
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