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Topic Review
Psoriasis
Psoriasis is a common immune-mediated inflammatory skin disease characterized by well-demarcated scaly raised plaques.
  • 1.0K
  • 22 Apr 2021
Topic Review
Properties and Applications of Levan
Polysaccharides play a crucial role in medicine, pharmacy, and cosmetology, as well as in the production of biofuels and biomaterials. Among microbial biopolymers, microbial levan, a fructose polysaccharide, holds significant promise due to its high productivity and chemical diversity. Levan exhibits a wide range of properties, including film-forming ability, biodegradability, non-toxicity, self-aggregation, encapsulation, controlled release capacity, water retention, immunomodulatory and prebiotic activity, antimicrobial and anticancer activity, as well as high biocompatibility. These exceptional properties position levan as an attractive candidate for nature-based materials in food production, modern cosmetology, medicine, and pharmacy. 
  • 999
  • 26 Jul 2023
Topic Review
Superficial Spindle Cell Mesenchymal Tumors
Superficial spindle cell mesenchymal tumors form a diverse group of lesions with benign and malignant entities that are often very similar clinically and/or histologically. In children, the patient’s age; the lesion site; the presentation as a mass, nodule, or plaque; and the location in the dermis or subcutis are important features that will guide the dermatologist and the pathologist.
  • 997
  • 02 Oct 2021
Topic Review
Chitosan/Graphene Oxide Composite Films
The healing of wounds is still one of the challenging clinical problems for which an efficient and fast treatment is needed. Therefore, recent studies have created a new generation of wound dressings which can accelerate the wound healing process with minimum side effects. Chitosan, a natural biopolymer, is an attractive candidate for preparing biocompatible dressings. The biodegradability, non-toxicity and antibacterial activity of chitosan have made it a promising biopolymer for treating wounds. Graphene oxide has also been considered by researchers as a non-toxic, inexpensive, and biocompatible material for wound healing applications. This review discusses the potential use of chitosan/graphene oxide composite films and their application in wound dressing and drug delivery systems. 
  • 995
  • 02 Sep 2021
Topic Review
Acetyl Zingerone
The cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is through induction of reactive oxygen species (ROS).
  • 992
  • 12 Jun 2023
Topic Review
Trichophyton indotineae
Trichophyton (T.) indotineae is a newly identified dermatophyte species that has been found in a near-epidemic form on the Indian subcontinent. There is evidence of its spread from the Indian subcontinent to a number of countries worldwide. The fungus is identical to genotype VIII within the T. mentagrophytes/T. interdigitale species complex, which was described in 2019 by sequencing the Internal Transcribed Spacer (ITS) region of ribosomal DNA of the dermatophyte.
  • 982
  • 27 Jul 2022
Topic Review
Desmosomal Genes
Desmosomes are mirroring, transmembrane protein chains that connect the intermediate filament networks of neighbouring cells. Each chain continuously (dis)assembles due to the turnover of five desmosomal protein types: desmoplakin, plakoglobin, plakophilins, desmocollins and desmogleins. The expression of two genes is critical to the formation of all desmosomes: namely DSP, encoding two differently spliced desmoplakin proteins (DPI and DPII) and JUP, encoding plakoglobin (PG). Meanwhile, plakophilins, desmocollins and desmogleins are expressed in a tissue-specific manner and are therefore encoded by multiple genes.
  • 973
  • 20 Oct 2022
Topic Review
Acne Inversa
Acne inversa, namely, Hidradenitis suppurativa (HS), is a chronic inflammatory skin disease affecting ~1% of the global population. HS typically occurs after puberty, with the average age of onset in the second or third decades of life and with a female predominance. Approximately one third of patients are genetically predisposed. Moreover, lifestyle factors, such as smoking and obesity, play a crucial role in the clinical course of HS.
  • 970
  • 29 Sep 2021
Topic Review
Asthma
Asthma is an inflammatory condition of the bronchial mucosa affecting 10% of children and 5% of adults in Western countries.
  • 963
  • 25 Apr 2021
Topic Review
Soluble Factors and Receptors in Skin Innate Immunity
The pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged lately, acknowledging they are involved in many cutaneous inflammatory, infectious, and neoplastic disorders. We extensively reviewed the implication of soluble factors in skin innate immunity. Furthermore, we showed which molecules target these factors, how these molecules work and how they've been used in dermatological practice. Cytokine inhibitors have paved the way to a new era in treating moderate to severe psoriasis and atopic dermatitis. 
  • 952
  • 13 Dec 2021
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