Topic Review
Cardiac Natriuretic Peptides, Their Receptors and Metabolism
Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones produced and released by cardiomyocytes, exerting several systemic effects. Together with C-type NP (CNP), mainly expressed by endothelial cells, they also exert several paracrine and autocrine activities on the heart itself, contributing to cardiovascular (CV) health. NPs prevent cardiac hypertrophy, fibrosis, arrhythmias and cardiomyopathies, counteracting the development and progression of heart failure (HF). Moreover, recent studies revealed that a protein structurally similar to NPs mainly produced by skeletal muscles and osteoblasts called musclin/osteocrin is able to interact with the NPs clearance receptor, attenuating cardiac dysfunction and myocardial fibrosis and promoting heart protection during pathological overload. This narrative review is focused on the direct activities of this molecule family on the heart, reporting both experimental and human studies that are clinically relevant for physicians. 
  • 2
  • 06 Dec 2022
Topic Review
Trop-2 as a Therapeutic Target in Breast Cancer
Trop-2 is an exciting, new target for the treatment of breast cancer. Trop-2 is found at high levels in multiple cancers such as prostate, pancreatic, urothelial, lung, and breast cancer. Among different breast cancer subtypes, Trop-2 is most highly expressed in triple negative breast cancer. Drugs that inhibit Trop-2 are now an important treatment option for patients with metastatic triple negative breast cancer, for whom few treatment options exist.
  • 4
  • 06 Dec 2022
Topic Review
The Extracellular Vesicles and Cardiovascular Diseases
Cardiovascular diseases (CVDs) are one of the leading causes of death worldwide. Accumulating evidences have highlighted the importance of exosomes and non-coding RNAs (ncRNAs) in cardiac physiology and pathology.
  • 9
  • 06 Dec 2022
Topic Review
UPLC Technique in Pharmacy
In recent years, ultra-efficient liquid chromatography (UPLC) has gained particular popularity due to the possibility of faster separation of small molecules. This technique, used to separate the ingredients present in multi-component mixtures, has found application in many fields, such as chemistry, pharmacy, food, and biochemistry. It is an important tool in both research and production. UPLC created new possibilities for analytical separation without reducing the quality of the obtained results. This technique is therefore a milestone in liquid chromatography. Thanks to the increased resolution, new analytical procedures, in many cases, based on existing methods, are being developed, eliminating the need for re-analysis. Researchers are trying to modify and transfer the analytical conditions from the commonly used HPLC method to UPLC. This topic may be of strategic importance in the analysis of medicinal substances. The information contained in this manuscript indicates the importance of the UPLC technique in drug analysis. 
  • 5
  • 06 Dec 2022
Topic Review
Natural Polymeric Nanoparticles for Drug Delivery in Osteoarthritis
Natural polymers include several polysaccharides of plant-based origin that are either positively or negatively charged. They may have linear or branched configurations with amine groups that can be protonated under acidic conditions. Their main advantages as drug delivery vehicles are the biodegradable and biocompatible properties, unique chemical variety and presence of adjustable active sites that confer improved physicochemical properties to different biological applications. As opposed to synthetic polymers, natural polymers can have bioactive effects (e.g., anti-inflammatory) in tissues like cartilage, thus holding an intrinsic therapeutical activity apart from the one provided by the encapsulated drugs. In addition, the inherent antioxidant and anticoagulation effects of polysaccharides ensure a low immunogenicity for in vivo applications. The main limitation in the use of natural polymers is the batch-to-batch variation, because they are derived from natural sources that have a less controlled composition.
  • 9
  • 06 Dec 2022
Topic Review
Skeletal Effects of Naringenin
Various natural compounds can positively influence the skeletal remodelling process, of which naringenin is a candidate. Naringenin is an anti-inflammatory and antioxidant compound found in citrus fruits and grapefruit. 
  • 4
  • 06 Dec 2022
Topic Review
Barrier Membranes for Guided Bone Regeneration
Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa and creating an underlying space to support bone growth. Different membrane types provide different biological mechanisms due to their different origins, preparation methods and structures. Among them, collagen membranes have attracted great interest due to their excellent biological properties and desired bone regeneration results to non-absorbable membranes even without a second surgery for removal.
  • 9
  • 06 Dec 2022
Topic Review
Synthesis of Carbon Dots
There are many studies on the different synthesis methods of carbon dots. Each process aims to improve the synthesis strategy and optimize the reaction conditions so that the carbon dots are not only more cost-effective and eco-friendly, but also provide more excellent performance.
  • 7
  • 06 Dec 2022
Topic Review
The Clinical Definitions of Treatment-Resistant Depression
Treatment-resistant depression is a pleomorphic phenomenon occurring in 30% of patients with depression. The chance to achieve remission decreases with every subsequent episode. It constitutes a significant part of the global disease burden, causes increased morbidity and mortality, and is associated with poor quality of life. It involves multiple difficult-to-treat episodes, with increasing resistance over time. The official consensus on the definition of TRD (treatment-resistant depression) is still lacking, but based on systematic analysis, the most used definition is a lack of response after two to three adequate antidepressant treatment trials, irrespective of the drug class, plus an adequate trial of psychotherapy.
  • 9
  • 06 Dec 2022
Topic Review
Strength and Weakness of NIBS-RAR Coupled Intervention
Robot-aided rehabilitation (RAR) and non-invasive brain stimulation (NIBS) are the two main interventions for post-stroke rehabilitation. The importance of coupling these interventions, which both enhance brain plasticity to promote recovery, lies in augmenting the rehabilitation potential to constrain the limitation in daily living activities and the quality of life following stroke.
  • 10
  • 06 Dec 2022
  • Page
  • of
  • 868
Top
Feedback