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Topic Review
Acorus tatarinowii Schott
Acorus tatarinowii Schott (A. tatarinowii) is a natural medicinal plant. It plays an indispensable role in the treatment of diseases by the empirical medicine system and has achieved remarkable curative effects.
  • 293
  • 12 Jun 2023
Topic Review
Annona muricata and Its Anticancer Activity
Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins.
  • 648
  • 14 Oct 2022
Topic Review
Arisaema Jacquemontii Blume
Arisaema jacquemontii Blume (Araceae) is a medicinally important plant and is used for the treatment of different diseases specially in dermatological disorders. Alkaloids, phenols, terpenes, flavonoids, glycosides, tannins have been reported from this plant. Antioxidant, antifungal, antibacterial and anticancer activities are also shown by Arisaema jacquemontii. 
  • 743
  • 15 Aug 2022
Topic Review
Aristotelia chilensis (Maqui Berry)
The Aristotelia chilensis (Mol.) Stuntz, also known as Maqui, is an endemic berry native to southern Chile. It is a very popular berry for its nutritional attributes and health benefits, provided mainly by its polyphenols.
  • 61
  • 29 Mar 2024
Topic Review
Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management
Artemisia annua (“sweet wormwood”, “qinghao”), a member of the Asteraceae family, has been traditionally used safely over the centuries to treat a variety of fevers, and notably, ‘‘intermittent fevers” and chills-related conditions, including respiratory tract infections. It also exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.
  • 953
  • 07 Jul 2022
Topic Review
Aspergillus sp. and Calcineurin Pathway
Aspergillus species, especially A. fumigatus, and to a lesser extent others (A. flavus, A. niger, A. terreus), although rarely pathogenic to healthy humans, can be very aggressive to immunocompromised patients (they are opportunistic pathogens). Calcineurin is a serine/threonine phosphatase activated by elevated concentrations of calcium, which connects upstream calcium signaling pathways to downstream protein signaling through changes in phosphorylation states.
  • 472
  • 27 Oct 2022
Topic Review
Aspergillus in Lung Transplant Recipients
Fungal infections are a significant source of morbidity in the lung transplant population via direct allograft damage and predisposing patients to the development of chronic lung allograft dysfunction. Prompt diagnosis and treatment are imperative to limit allograft damage.  Aspergillus is among one of the most common sources of fungal infections in lung transplant recipients (LTR).
  • 191
  • 06 Jun 2023
Topic Review Peer Reviewed
Astragalus membranaceus (Huangqi) Supplementation in Sports Training: A Systematic Review
The aim of this systematic review is to study the effects of Astragalus membranaceus (Huangqi) supplementation for sports activity and physical performance. PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar were systematically searched for relevant studies from inception up until October 2023. Eleven clinical studies were considered eligible for inclusion (six of them involved the administration of Huangqi alone, while, in the remaining trials, this herb was supplemented in combination with other remedies). On average, the number of study participants ranged from 8 to 120, and the sports activities practiced by the subjects included martial arts, mountain hiking, basketball, rowing, running, aerobic exercises, and strength training. When a dried extract was used, Astragalus was taken at a daily dose of 1 to 4 g for several weeks. Huangqi supplementation was associated with improvements in aerobic performance, oxidative status, reticulocytes percentage, and response to acclimatization, without a specific effect on the athletes’ strength. Better post-exercise immune functions were also observed, especially with regard to NK cell activity, IL-2 levels, CD4+/CD8+ ratio, and lymphocyte turnover. No adverse effects were described. In conclusion, Astragalus supplementation has the potential to decrease fatigue, enhance aerobic performance, and mitigate post-exercise immune suppression in athletes. It is advisable to conduct additional research on the subject to enhance the robustness of the existing evidence through larger-scale controlled trials.
  • 155
  • 30 Jan 2024
Topic Review
Brucella Spondylitis
The most prevalent zoonotic disease is brucellosis, which poses a significant threat for worldwide public health. Particularly in endemic areas, spinal involvement is a major source of morbidity and mortality and can complicate the course of the disease. 
  • 91
  • 01 Feb 2024
Topic Review
Caenorhabditis elegans for Screening Probiotics with Antiobesity Properties
Due to the role of gut microbiota in the regulation of lipid, glucose, and insulin homeostasis, probiotics with beneficial properties have emerged as an alternative therapeutic tool to ameliorate metabolic diseases-related disturbances, including fat excess or inflammation. Different strains of bacteria, mainly lactic acid bacteria (LAB) and species from the genus Bifidobacterium, have emerged as potential probiotics due to their anti-obesogenic and/or anti-diabetic properties. However, in vivo studies are needed to demonstrate the mechanisms involved in these probiotic features. In this context, Caenorhabditis elegans has emerged as a very powerful simple in vivo model to study the physiological and molecular effects of probiotics with potential applications regarding the different pathologies of metabolic syndrome.
  • 58
  • 18 Feb 2024
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