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Topic Review
Biography
Topic Review
(1,3;1,4)-β-D-Glucans
(1,3;1,4)-β-D-Glucans, also named as mixed-linkage glucans, are unbranched non-cellulosic polysaccharides containing both (1,3)- and (1,4)-β-linkages. The linkage ratio varies depending upon species origin and has a significant impact on the physicochemical properties of the (1,3;1,4)-β-D-glucans.
1.3K
24 Sep 2021
Topic Review
[GADV]-amino Acids and GNC Codons Selected
The genetic code connecting gene with protein is one of the six members (gene, tRNA, genetic code, protein, metabolism, and cell structure) composing the fundamental life system, including the core life system (gene, tRNA, genetic code, and protein). Revealing the origin of the genetic code, one of four members of the core life system might lead to solving the mystery of the origin of life. Therefore, it is quite important to clarify how amino acids and codons were selected among messy organic compounds on primitive Earth and how the first genetic code was established.
312
15 Feb 2023
Topic Review
m6A RNA Methylation Mechanism
Epitranscriptomic modifications can affect every aspect of RNA biology, including stability, transport, splicing, and translation, participate in global intracellular mRNA metabolism, and regulate gene expression and a variety of biological processes. N6-methyladenosine (m6A) as the most prevalent modification contributes to normal embryonic brain development and memory formation.
732
08 Jun 2022
Topic Review
Bifidobacterium
Mechanism of Action
Major mechanisms of Bifidobacterium action include modulation of adaptive and innate immunity, enhancement of intestinal epithelial barrier, prevention of pathogen adhesion, and production of antimicrobial compounds.
1.9K
23 Feb 2023
Topic Review
Caenorhabditis elegans
Models Established for Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease characterised by the selective and gradual loss of motor neurons in the spinal, bulbar and cortical regions. C. elegans has established itself as a favoured model organism in the field of neurodegenerative disease research. Through analysis of gene mutations pertinent to these disease, it provides a unique opportunity to identify pathogenic molecular pathways and explore promising therapeutic options.
173
10 Jan 2024
Topic Review
Genista tridentata
Phytochemical Characterization
Genista tridentata (L.) Willk., known as “prickled broom”, is a Leguminosae (Fabaceae) species native to the Iberian Peninsula, Morocco, Algeria, and Tunisia. It is used in folk medicine as an anti-inflammatory, for gastrointestinal and respiratory disorders, rheumatism, and headaches, to lower blood pressure, against hypercholesterolemia and hyperglycemia.
226
08 Nov 2023
Topic Review
MBOAT7
in Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is a common and prevalent disorder affecting 25 percent of the adults in the United States and 32 percent of adults globally. It is one of the common causes of chronic liver disease characterized by steatosis, which can lead to inflammation, fibrosis, and cirrhosis. NAFLD is strongly associated with obesity and insulin resistance. Multiple genetic variants have been consistently found to be associated with NAFLD; one of them is found in the TMC4-MBOAT7 loci. One variant (rs641738 C>T) within MBOAT7 encoding lysophosphatidyl inositol acyltransferase increases the risk for NAFLD development and triggers hepatic inflammation by regulating arachidonic acid levels.
111
27 Dec 2023
Topic Review
PAX5
Expression and Regulation
PAX5, a member of the Paired Box (PAX) transcription factor family, is an essential factor for B-lineage identity during lymphoid differentiation. Mechanistically, PAX5 controls gene expression profiles, pivotal to cellular processes such as viability, proliferation, and differentiation. Given its crucial function in B-cell development, PAX5 aberrant expression also correlates with hallmark cancer processes leading to hematological and other types of cancer lesion.
666
26 Sep 2022
Topic Review
Tafazzin
in Mitochondrial Function, Development and Disease
Tafazzin, an enzyme associated with the rare inherited x-linked disorder Barth Syndrome, is a nuclear encoded mitochondrial transacylase that is highly conserved across multiple species and plays an important role in mitochondrial function.
360
15 Jul 2022
Topic Review
TaNACs
in Wheat Crop Improvement
Wheat (Triticum aestivum) is one of the main staple food crops cultivated around the world. Although it is a very important cereal crop, it is underexplored compared to rice, barley, and maize. The main reason is its large and complex hexaploid genome, AABBDD (2n = 6x = 42), which has three homoeologous sets of genes that make research more demanding. The genome of rice is diploid, 33 times smaller than that of wheat; therefore, this species is very well explored and treated as a model among cereals. Barley and maize are diploid species. However, the first one is more closely related to wheat, thus reports on the cis-regulation of genes in these two species, rice, and barley, by NAC TFs are also discussed and compared with wheat.
419
27 Dec 2022
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