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Topic Review
Fungal Urinary Tract Infection
Fungal urinary tract infections (FUTI) are mainly caused by Candida species. The urine can be an important specimen for the diagnosis of this kind of clinical condition since both the presence of fungi can be identified by urine microscopy and by uroculture and the cells that promotes the immune response against this kind of infectious agent can also be observed. This entry will focus on information related to FUTI and the urinary findings that can be detected during routine urinalysis that can contribute to the identification of this clinical condition.
  • 16.3K
  • 29 Mar 2021
Topic Review
Secretory IgA
Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions, it is also present in saliva and breast milk. The majority of plasma cells producing SIgA are located within mucosal membranes lining the intestines, airway and reproductive tracts, as well as mammary gland. SIgA protects against the adhesion of pathogens and their penetration into the mucosal barriers. Moreover, SIgA regulates microbiota composition at mucosa sites and provides local homeostasis.
  • 3.6K
  • 17 Jan 2021
Topic Review
Neutrophils in Pregnancy, Term and Preterm Labour
Neutrophils are surveillance cells, and the first to react and migrate to sites of inflammation and infection following a chemotactic gradient. Neutrophils play a key role in both sterile inflammation and infection, performing a wide variety of effector functions such as degranulation, phagocytosis, ROS production and release of neutrophil extracellular traps (NETs). Healthy term labour requires a sterile pro-inflammatory process, whereas one of the most common causes of spontaneous preterm birth is microbial driven. Peripheral neutrophilia has long been described during pregnancy, and evidence exists demonstrating neutrophils infiltrating the cervix, uterus and foetal membranes during both term and preterm deliveries. Their presence supports a role in tissue remodelling via their effector functions.
  • 3.5K
  • 30 Oct 2022
Topic Review
Myeloid-Derived Suppressor Cells
Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells derived from bone marrow. They are precursors of dendritic cells, macrophages and/or granulocytes. They have the ability to significantly inhibit immune cell responses.
  • 2.6K
  • 27 Oct 2020
Topic Review
Immunopeptidome
Major histocompatibility complex class I (MHC I) plays a crucial role in the development of adaptive immune response in vertebrates. MHC molecules are cell surface protein complexes loaded with short peptides and recognized by the T-cell receptors (TCR). Peptides associated with MHC are named immunopeptidome. The MHC I immunopeptidome is produced by the proteasome degradation of intracellular proteins. The knowledge of the immunopeptidome repertoire facilitates the creation of personalized antitumor or antiviral vaccines. A huge number of publications on the immunopeptidome diversity of different human and mouse biological samples - plasma, peripheral blood mononuclear cells (PBMCs), and solid tissues, including tumors - appeared in the scientific journals in the last decade. Significant immunopeptidome identification efficiency was achieved by advances in technology: the immunoprecipitation of MHC and mass spectrometry-based approaches.
  • 2.3K
  • 30 Nov 2020
Topic Review
Neutrophil and Natural Killer Cell Interactions in Cancers
Neutrophils are the most abundant circulating leukocytes, accounting for 50–70% of blood cells. Natural killer (NK) cells are large granular lymphocytes from innate immunity, participating in virus-infected and malignant-transformed cells recognition and elimination.
  • 2.0K
  • 29 Mar 2022
Topic Review
Acquired Cytomegalovirus Infection Hearing Loss
Congenital cytomegalovirus (CMV) infection induces a clinical syndrome usually associated with hearing loss. However, the effect of acquired CVM infection in adults and children has not been clearly defined.
  • 2.0K
  • 28 Dec 2020
Topic Review
Dietary Fibre from Virgin Sugarcane
Prebiotic dietary fibre (DF) has gained significant research attention owing to its reported potential in conferring health benefits through modulating gut microbiota composition and their metabolic activities. Complex dietary fibres from whole-plant sources are becoming recognised as vital parameters in influencing the gut microbial diversity in contrast to isolated or purified DF forms. In this entry, we review the recent evidence from in-vivo and clinical studies to support the significant prebiotic capacity of whole-plant virgin processed sugarcane fibre in countering gut inflammation and undesirable digestive symptoms.
  • 1.9K
  • 16 Mar 2021
Topic Review
Aryl-hydrocarbon Receptor
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates numerous cellular responses. Originally investigated in toxicology because of its ability to bind environmental contaminants, AhR has attracted enormous attention in the field of immunology in the last 20 years. In addition, the discovery of endogenous and plant-derived ligands points to AhR also having a crucial role in normal cell physiology. Thus, AhR is emerging as a promiscuous receptor that can mediate either toxic or physiologic effects upon sensing multiple exogenous and endogenous molecules. Within this scenario, several factors appear to contribute to the outcome of gene transcriptional regulation by AhR, including the nature of the ligand as such and its further metabolism by AhR-induced enzymes, the local tissue microenvironment, and the presence of coregulators or specific transcription factors in the cell.
  • 1.8K
  • 07 Dec 2021
Topic Review
Anti-Ro Antibodies and fetal complications
Maternal anti-Ro antibodies present during the fetal period can cause complications ranging from congenital heart block, fetal demise or long-term consequences. The anti-Ro induced autoimmune reaction causes long-term fibrosis and calcification of the conductive tissue. In addition, the CHB injury mechanisms were shown to involve other factors, like fetal susceptibility that increases for every subsequent pregnancy, from a 2% incidence in the case of nulliparous mothers. The predictive value of maternal anti-Ro antibodies for CHB high-risk pregnancy is low, and other markers are lacking, making this condition difficult to efficiently monitor. Moreover, the positive anti-Ro pregnancies do not benefit from a prophylactic treatment or from an efficient therapy once CHB was diagnosed. Thus, new data from ongoing trials are highly expected, to provide both potential biomarkers and therapeutic solutions. This entry illustrates the current understanding of the anti-Ro antibodies associated pathologies, from the perspective of specialists involved in its management, emphasizing key issues, missing links, and possible future directions for an effective interdisciplinary approach.
  • 1.8K
  • 08 Nov 2020
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