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Topic Review
Biography
Topic Review
Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties
Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear.
37
21 Mar 2024
Topic Review
Molecular Serum Albumin
Serum albumin is a popular macromolecule for studying the effect of proteins on the colloidal stability of nanoparticle (NP) dispersions, as well as the protein–nanoparticle interaction and protein corona formation.
45
05 Mar 2024
Topic Review
Cell Envelope Synthesis Enzymes
Life-threatening systemic fungal infections occur in immunocompromised patients at an alarming rate. Current antifungal therapies face challenges like drug resistance and patient toxicity, emphasizing the need for new treatments. Membrane-bound enzymes account for a large proportion of antifungal targets, especially ones that contribute to cell wall and cell membrane biosynthesis. Moreover, structural biology has led to a better understanding of the mechanisms by which these enzymes synthesize their products, as well as the mechanism of action for some antifungals.
40
27 Feb 2024
Topic Review
Heart Failure
Heart failure (HF) is marked by dampened cardiac contractility. A mild therapeutic target that improves contractile function without desensitizing the β-Adregenric system during HF may improve cardiac contractility and potentially survival. Inhibiting PKCα activity may fit the criteria of the therapeutic target with milder systemic effects that still boosts contractility in HF patients. PKCα activity has been observed to increase during HF. This increase in PKCα activity is perplexing because it is also accompanied by the up-regulation of a molecular braking mechanism.
1.4K
17 Feb 2024
Topic Review
Cancer Metastasis from Physical Perspective
Tumor diseases become a huge problem when they embark on a path that advances to malignancy, such as the process of metastasis. Cancer metastasis has been thoroughly investigated from a biological perspective in the past, whereas it has still been less explored from a physical perspective. Until now, the intraluminal pathway of cancer metastasis has received the most attention, while the interaction of cancer cells with macrophages has received little attention. Apart from the biochemical characteristics, tumor treatments also rely on the tumor microenvironment, which is recognized to be immunosuppressive and, as has recently been found, mechanically stimulates cancer cells and thus alters their functions.
62
09 Feb 2024
Topic Review
Cells Respond to Mechanical Cues of Extracellular Matrix
Extracellular biophysical properties have particular implications for a wide spectrum of cellular behaviors and functions, including growth, motility, differentiation, apoptosis, gene expression, cell–matrix and cell–cell adhesion, and signal transduction including mechanotransduction. Cells not only react to unambiguously mechanical cues from the extracellular matrix (ECM), but can occasionally manipulate the mechanical features of the matrix in parallel with biological characteristics, thus interfering with downstream matrix-based cues in both physiological and pathological processes. Bidirectional interactions between cells and (bio)materials in vitro can alter cell phenotype and mechanotransduction, as well as ECM structure, intentionally or unintentionally. Interactions between cell and matrix mechanics in vivo are of particular importance in a variety of diseases, including primarily cancer.
53
31 Jan 2024
Topic Review
Neuroprotective Effect of Fullerenes
The use of carbon nanomaterials including fullerenes, carbon nanotubes, carbon nano-onions, carbon dots and carbon quantum dots for environmental applications has increased substantially. These nanoparticles are now used in the development of sensors and switches, in agriculture as smart fertilizers and in the biomedical realm for cancer therapy intervention, as antioxidants, in gene delivery and as theranostics.
113
29 Jan 2024
Topic Review
Functional Near-Infrared Spectrometry
Functional Near-Infrared Spectroscopy (fNIRS) has emerged as a promising tool for understanding the human brain’s complex workings due to its ability to measure changes in oxygenated and deoxygenated hemoglobin levels, thus providing insights into neural activity and functional connectivity. fNIRS technology offers a novel approach to studying brain function, especially visual processing and perception. fNIRS offers unique advantages, such as portability, cost-effectiveness and safety, making it suitable for clinical and research applications. Additionally, the combination of fNIRS with emerging technologies like virtual reality (VR), augmented reality (AR) and artificial intelligence (AI) opens new avenues for immersive investigations into brain function.
137
29 Jan 2024
Topic Review
Uses of Magnetic Fields for Health Applications
Early life on Earth evolved in the contexts of temperature, available elements, and molecules (including water), as well as the biophysical boundary conditions of the planet. The latter include gravity (1 g), exogenous and endogenous radiation from particles from beyond Earth and radioactive elements on Earth, and magnetic fields due to the planet’s magnetic field and local concentrations of molecules such as iron. Humans and other animals, plants, and microorganisms have been exposed to a variety of magnetic fields other than the geomagnetic field of Earth and deposits of ferro materials. Magnetic fields, static or electromagnetic, have been used in attempts to improve outcomes for the repair of a variety of tissues.
52
24 Jan 2024
Topic Review
The DNA Alkyltransferase Family of DNA Repair Proteins
DNA alkyltransferase and alkyltransferase-like family proteins are responsible for the repair of highly mutagenic and cytotoxic O6-alkylguanine and O4-alkylthymine bases in DNA. Their mechanism involves binding to the damaged DNA and flipping the base out of the DNA helix into the active site pocket in the protein. Alkyltransferases then directly and irreversibly transfer the alkyl group from the base to the active site cysteine residue. In contrast, alkyltransferase-like proteins recruit nucleotide excision repair components for O6-alkylguanine elimination. One or more of these proteins are found in all kingdoms of life, and where this has been determined, their overall DNA repair mechanism is strictly conserved between organisms.
197
19 Jan 2024
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