Topic Review
Zirconolite and Murataite for the Immobilization of Actinides
Zirconolite is highly stable in nature, with isotope systems that have been closed for hundreds of million years, making it possible for age determination. Murataite is a very rare mineral, its synthetic counerpart was first discovered in the Synroc matrix from defense waste obtained by sintering. Synthetic zirconolie and murataite can be applied for nuclear waste immobilization. 
  • 29
  • 14 Sep 2022
Topic Review
Structure and Functions of Aβ and Tau Proteins
The amyloid hypothesis, i.e., the abnormal accumulation of toxic Aβ assemblies in the brain, has been considered the mainstream concept sustaining research in Alzheimer’s Disease (AD). However, the course of cognitive decline and AD development better correlates with tau accumulation rather than amyloid peptide deposition. Moreover, all clinical trials of amyloid-targeting drug candidates have been unsuccessful, implicitly suggesting that the amyloid hypothesis needs significant amendments. Accumulating evidence supports the existence of a series of potentially dangerous relationships between Aβ oligomeric species and tau protein in AD.
  • 76
  • 29 Aug 2022
Topic Review
Synthesis Procedures of Porphyrin-Based Metal–Organic Frameworks
Metal–organic frameworks (MOFs)—typically formed from metal ions/clusters bridged by multidentate ligands in an extended framework—have provided solutions to tackle challenges in areas such as catalysis. By either integrating porphyrins/metalloporphyrins inside pores freely in situ or by grafting on the surface using post-synthetic methods and/or as part of the network component, porphyrin-based MOFs could be easily constructed.
  • 44
  • 24 Aug 2022
Topic Review
Methods to Synthesize Ultrasmall AuNPs
Gold nanoparticles (AuNPs) are continuing to gain popularity in the field of nanotechnology. New methods are continuously being developed to tune the particles’ physicochemical properties, resulting in control over their biological fate and applicability to in vivo diagnostics and therapy. The common methods of synthesizing ultrasmall AuNPs are presented.
  • 62
  • 09 Aug 2022
Topic Review
Catalysts for Glycerol Reforming
The valuable products produced from glycerol transformation have become a research route that attracted considerable benefits owing to their huge volumes as well as a myriad of chemical and biological techniques for transforming glycerol into high-value compounds, such as fuel additives, biofuels, precursors, and other useful chemicals, etc. Steam, aqueous, and autothermal reforming processes have been primarily investigated in glycerol reforming. An update on glycerol reforming is given, with an exclusive focus on the various catalyst's performance in designing reaction operation conditions.
  • 58
  • 25 Jul 2022
Topic Review
Role of Water in B-Form DNA
DNA in the cell is rarely naked but normally protein-bound in nucleosomes. Of special interest is the DNA bound to other factors that control its key functions of transcription, replication, and repair. For these several transactions of DNA, the state of hydration plays an important role in its function, and therefore needs to be defined in as much detail as possible. High-resolution crystallography of short B-form duplexes shows that the mixed polar and apolar surface of the major groove binds water molecules over the broad polar floor of the groove in a sequence-dependent varied manner.
  • 50
  • 01 Jul 2022
Topic Review
Synthesis of Ferrocenyl Phosphorhydrazone Dendrimers
The discovery of ferrocene is often associated with the rapid growth of organometallic chemistry. Dendrimers are highly branched macromolecules that can be functionalized at will at all levels of their structure. The functionalization of dendrimers with ferrocene derivatives can be carried out easily as terminal functions on the surface, but also at the core, or at one or several layers inside the structure. Depending on the desired location of the ferrocenes in the structure of phosphorhydrazone dendrimers, the ferrocenes should be functionalized differently. For the grafting to the surface, the ferrocene should bear a phenol group, suitable to react in substitution reactions with the P(S)Cl2 terminal groups of the dendrimers. To be used as core, the ferrocene should have two aldehyde functions, from which the synthesis of the dendrimer will be carried out. To be introduced in the branches, at all layers or within a single layer, the ferrocene should replace hydroxybenzaldehyde; thus, it should bear both a phenol and an aldehyde.
  • 105
  • 06 Jun 2022
Topic Review
Brief History of Oxygen
Oxygen, a paramagnetic, diradical gaseous (at room temperature) molecule, is instrumental to life as we know it. It is also crucial to some medical therapies, used in multiple industries and has even been found on other planets. The importance of oxygen cannot be overplayed.
  • 74
  • 28 Apr 2022
Topic Review
Boron Chemicals
Boron-based bioactive compounds have provided amphiphilic properties to facilitate interaction with protein targets. Indeed, the spectrum of boron-based entities as drug candidates against many diseases has grown tremendously since the first clinically tested boron-based drug, Velcade. 
  • 186
  • 27 Apr 2022
Topic Review
Platinum Based Cytostatic Drugs
Platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. 
  • 140
  • 19 Apr 2022
  • Page
  • of
  • 6
Top
Feedback