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Topic Review
β-Carotene Supplementation and Risk of Cardiovascular Disease
β-carotene is widely available in plant-based foods. β-carotene supplementation had no beneficial effects on cardiovascular disease (CVD) incidence and potential harmful effects on CVD mortality. 
  • 670
  • 29 Mar 2022
Topic Review
Zearalenone and the Immune Response
Zearalenone (ZEA) is an estrogenic fusariotoxin, being classified as a phytoestrogen, or as a mycoestrogen. ZEA and its metabolites are able to bind to estrogen receptors, 17β-estradiol specific receptors, leading to reproductive disorders which include low fertility, abnormal fetal development, reduced litter size and modification at the level of reproductive hormones especially in female pigs. ZEA has also significant effects on immune response with immunostimulatory or immunosuppressive results. This review presents the effects of ZEA and its derivatives on all levels of the immune response such as innate immunity with its principal component inflammatory response as well as the acquired immunity with two components, humoral and cellular immune response. The mechanisms involved by ZEA in triggering its effects are addressed. 
  • 403
  • 26 Apr 2021
Topic Review
YB1 in Triple Negative Breast Cancer
The Y Box binding protein 1 (YB1) is a multifunctional protein, found both in the cytoplasm and inside the nucleus, that belongs to the highly conserved Cold Shock Domain protein family. YB1 is highly expressed in TNBC tumors of AA origin when compared to CAs. Increased expression levels and activity of YB1 correlates with poor disease outcomes, resistance to chemotherapy, and the activation of the cancer stem cell (CSC) phenotype, with higher levels in AA than in CA TNBC tumors.
  • 526
  • 23 Dec 2021
Topic Review
World-Renowned “Swiss” Pediatricians
The early and correct recognition of rare pediatric diseases is essential for decisions related to treatment options, the monitoring of treatment results, and the prevention of complications, as well as the estimation of prognosis and the counselling of patients, parents, and caregivers, including a risk estimation for recurrence in future pregnancies.
  • 50
  • 04 Dec 2023
Topic Review
Workplace Based Sampler Comparison Review
A narrative review on peer-reviewed literature reporting comparisons of personal samplers in workplace settings published between 2004 and 2020 was carried out. Search terms were developed for Web of Science and PubMed bibliographic databases. The retrieved studies were screened for relevance, with those studies meeting the inclusion criteria being taken forward to data extraction (22 studies). The inhalable fraction was the most common fraction assessed, with the IOM sampler being the most studied sampler. The most common workplace environment where samplers had been compared was that where metals/metalloids were present. The requirements of EN13205 standard (Workplace exposure. Assessment of sampler performance for measurement of airborne particle concentrations) have also been considered, with these requirements not currently being met, or at least referred to, in the reviewed literature. A number of conclusions have been drawn from this narrative review. For studies that reported correction factors, no discernible trends could be identified.
  • 442
  • 08 Jul 2021
Topic Review
Work-Related Stress during Home-Based Remote Work
Remote work takes place outside a designated work location, such as corporate offices, and is often associated with working from home or working (home-based remote work) at a client’s location. In contrast, telework can be conducted remotely as well, but also focuses on the use of personal electronical devices . Ideally, job demands and job resources behave in a dynamic, balanced manner that lead to or maintain employee health. However, when work demands exceed work resources and work resources are inadequate for work demands, an imbalance occurs that leads to WRS over time.
  • 416
  • 31 May 2022
Topic Review
Work-Related Impacts of Cancer Caregiving
Individuals with cancer commonly rely on their informal caregivers (e.g., spouse/partner, family member, close friend) to help them manage the demands of the disease and its treatment. Caregiving, including helping with patient care, performing household chores, and providing emotional and practical support, can be particularly demanding for employed caregivers, who must juggle their work responsibilities while providing care. The work-related impacts of informal cancer caregiving that have been investigated in the literature include: (1) labor market withdrawal to provide care, (2) work modifications, (3) absenteeism, and, (4) presenteeism.
  • 194
  • 08 Sep 2022
Topic Review
Work-Related Exhaustion in East and West Germany
Chronic exhaustion is a consequence of detrimental working conditions and demands, as well as inadequate coping techniques, potentially resulting in burnout. Previous research has studied occupational environment and individual factors as predictors of exhaustion. These differ between former East and West German states, the regional distinction regarding exhaustion has been neglected. 
  • 310
  • 23 Sep 2022
Topic Review
Work-Related Burnout among Corporate Employees
Work is an essential part of our daily life. It has been estimated that on average, full-time workers in OECD countries spend about 37% of their time working in a normal day.  Burnout is classified as an occupational phenomenon, not as a medical condition, in the 11th version of the International Classification of Diseases (ICD-11). It is defined as: ”a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed”.
  • 406
  • 27 Jan 2022
Topic Review
Work Composition after Spine Surgery
Low back pain (LBP) is currently the leading cause of disability worldwide and the most common reason for workers’ compensation (WC) claims. Studies have demonstrated that receiving WC is associated with a negative prognosis following treatment for a vast range of health conditions. However, the impact of WC on outcomes after spine surgery is still controversial.
  • 415
  • 23 Jun 2021
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