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Topic Review
Neighbourhood Socioeconomic Processes and Dynamics and Healthy Ageing
Elderly citizens are concentrated in urban areas and are particularly affected by the immediate residential environment. Cities are unequal and segregated places, where there is an intensification of urban change processes such as gentrification and displacement. Since older adults spend most of their time in their nearby neighbourhood environment due to physical, emotional, and financial reasons, it is essential to understand how the neighbourhood environment affects this population's health. 
  • 495
  • 10 Jun 2022
Topic Review
COVID-19-Related Neuro Events and Adverse Outcome Pathways
Several reports have shown that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has the potential to also be neurotropic. Four Adverse Outcome Pathways (AOPs) leading to neurological adverse outcomes (AO), anosmia, encephalitis, stroke, and seizure, were developed. Biological key events (KEs) identified to induce these AOs included binding to ACE2, blood–brain barrier (BBB) disruption, hypoxia, neuroinflammation, and oxidative stress. The modularity of AOPs allows the construction of AOP networks to visualize core pathways and recognize neuroinflammation and BBB disruption as shared mechanisms.
  • 493
  • 11 Nov 2022
Topic Review
Blockchain Technology in Healthcare
Blockchain technology, a distributed ledger based on peer to peer networks, has been gaining high popularity in healthcare.
  • 495
  • 23 Nov 2021
Topic Review
Antimicrobial Use in COVID-19 Patients
There is an urgent need for further research and guidance in this field, from producing evidence-based guidelines, reassessing biomarkers for antimicrobial stewardship in COVID-19 patients, understanding drivers, benefits, and disbenefits of antibiotic use, and assessing the wider impact of the pandemic on antimicrobial use (AMU) and AMR. In this scoping review, we aim to: add to the research evidence on prevalence and patterns of antimicrobial use in the treatment of COVID-19 patients; identify the most commonly used antibiotics and clinical scenarios associated with AMU; and to explore any impact of AMU on patient treatment outcomes.
  • 495
  • 30 Jun 2021
Topic Review
Pediatric Medical Devices
Children represent the future, and ensuring their physical, socio-emotional, language, and cognitive development is integral to health technology development. The development of a child from term or preterm neonate to a fully mature individual relies on complex physiological, anatomical, developmental, and social changes. Understanding the inter- and intra-population differences within the pediatric subpopulations is necessary to address the existing challenges and break down some of the long-recognized barriers. There is thus a clear need for research infrastructure and networks with the depth of expertise to support pediatric device development through collaboration across the life sciences sector. 
  • 495
  • 10 Jan 2022
Topic Review
Palatal Rugae Pattern after Orthodontic Treatment
Palatal rugae are the irregular connective tissue also known as “plicae palatinae. These are anatomical folds located posterior to the incisive papilla in the palatal anterior third. These folds, which form as early as 3 months in utero, are largely attributed to the hardened connective tissue that covers the bone. Their orientation and pattern are formed in the fourth month of intrauterine life. Their uniqueness lies in the fact that they are stable and show post-mortem resistance until oral mucosal degeneration after death . Their anatomical location on the internal aspect of the oral cavity protects them from different environmental factors including rising temperature, palatal infections, trauma, and tooth exfoliation and eruption. They are considered suitable landmarks for forensic identification.
  • 495
  • 25 Feb 2022
Topic Review
Regulation Mechanism of ssDNA Aptamer in Nanozymes
Food safety issues are a worldwide concern. Pathogens, toxins, pesticides, veterinary drugs, heavy metals, and illegal additives are frequently reported to contaminate food and pose a serious threat to human health. Conventional detection methods have difficulties fulfilling the requirements for food development in a modern society. Therefore, novel rapid detection methods are urgently needed for on-site and rapid screening of massive food samples. Due to the extraordinary properties of nanozymes and aptamers, biosensors composed of both of them provide considerable advantages in analytical performances, including sensitivity, specificity, repeatability, and accuracy. They are considered a promising complementary detection method on top of conventional ones for the rapid and accurate detection of food contaminants.
  • 495
  • 11 Mar 2022
Topic Review
Pacific Open Learning Health Net
Pacific Open Learning Health Net (POLHN /ˈpɒlhən/) is a non-profit established in 2003, focused on distance education for health professionals working in the Pacific. Since 2004, it has provided free online courses for continuing professional development in a wide range of health and science related disciplines. These include self-directed, blended learning, instructor-led and hybrid courses. The platform runs on a free and open-source software learning management system. POLHN works with several universities institutions and Ministries of Health to develop online health related courses guided by WHO publications and accepted standard operating procedure. Since 2013, the platform has resembled a typical massive open online course (MOOC) platform.
  • 495
  • 02 Dec 2022
Topic Review
Total Skin Treated by Helical Tomotherapy
Helical tomotherapy (HT) is a rotational intensity-modulated radiotherapy with a unique gantry mechanical design that can deliver highly conformal dose distributions to provide an alternative approach for total body irradiation or total marrow irradiation. 
  • 495
  • 10 Mar 2023
Topic Review
Periodontitis Classification, Clinical Features and Diagnosis
Periodontitis is a clinical condition where there is chronic inflammation of the periodontium, resulting in the loss of the periodontal ligament and damage to the surrounding alveolar bone. Various microorganisms have been linked to periodontitis. Chronic inflammation is responsible for various complications which are seen in periodontitis cases. For better treatment and diagnosis, it is important to understand the association of periodontitis with other systemic diseases.
  • 495
  • 31 Oct 2022
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