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Topic Review
Liquid Biopsy in Cancer
Liquid biopsy (LBx) is a novel and promising approach in precision medicine, suitable for patient management in a wide range of medical conditions. Its utility in oncology ranges from disease screening to early diagnosis and treatment. LBx has several strengths, such as safeness, quickness of execution, and repeatability, compared to old-fashioned solid biopsy techniques; indeed, LBx requires the collection of a small number of biospecimens. LBx has been proven to be accurate and reliable, as demonstrated in several clinical studies, and it could have a surprising impact on survival and quality of life for cancer patients in the near future.
  • 513
  • 17 Nov 2022
Topic Review
Heart Diet in Prevention of Heart Failure
Antioxidants, such as polyphenolics and flavonoids, omega-3 fatty acids, and other micronutrients that are rich in Indo-Mediterranean-type diets, could be protective in sustaining the oxidative functions of the heart. The cardiomyocytes use glucose and fatty acids for the physiological functions depending upon the metabolic requirements of the heart. Apart from toxicity due to glucose, lipotoxicity also adversely affects the cardiomyocytes, which worsen in the presence of deficiency of endogenous antioxidants and deficiency of exogenous antioxidant nutrients in the diet. The high-sugar-and-high-fat-induced production of ceramide, advanced glycation end products (AGE) and triamino-methyl-N-oxide (TMAO) can predispose individuals to oxidative dysfunction and Ca-overloading. The alteration in the biology may start with normal cardiac cell remodeling to biological remodeling due to inflammation. It is proposed that a greater intake of high exogenous antioxidant restorative treatment (HEART) diet, polyphenolics and flavonoids, as well as cessation of red meat intake and egg, can cause improvement in the oxidative function of the heart, by inhibiting oxidative damage to lipids, proteins and DNA in the cell, resulting in beneficial effects in the early stage of the Six Stages of heart failure (HF). 
  • 513
  • 09 Aug 2022
Topic Review
The Danish Pharmacy Practice Network
The Danish Network for Pharmacy Practice Research and Development (NUAP) is a network of Danish pharmacy owners and employees and Danish pharmacy practice researchers. The overall aim of the network is to strengthen pharmacy practice and pharmacy practice research in Denmark by providing a forum where researchers and representatives of community pharmacies meet to share knowledge and support evidence-based community pharmacy practice.
  • 514
  • 02 Jul 2021
Topic Review
Sense of Coherence and Well-Being in Care Professionals
Job-related stress affects the physical and psychological health of professionals dedicated to care, and consequently affects the effectiveness of the entities for which they work. It is important to determine the relationships between a sense of coherence (SOC) and work stress and well-being perceived by care professionals. 
  • 512
  • 17 Oct 2023
Topic Review
Neuropsychological Outcomes Associated with COVID-19
Survivors of COVID-19 often report subjective, cognitive complaints following infection, grossly characterized by cognitive inefficiency or “brain fog”. The nature of their objective, neuropsychological presentations are only beginning to be characterized. Risk factors predictive of neuropsychological outcomes post-infection remain under study. The contagiousness and quick rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, as well as the significant impact of COVID-19 disease on public health, make the study of COVID-19 on neuropsychological functioning particularly important. 
  • 512
  • 05 May 2022
Topic Review
Work-Related Exhaustion in East and West Germany
Chronic exhaustion is a consequence of detrimental working conditions and demands, as well as inadequate coping techniques, potentially resulting in burnout. Previous research has studied occupational environment and individual factors as predictors of exhaustion. These differ between former East and West German states, the regional distinction regarding exhaustion has been neglected. 
  • 512
  • 23 Sep 2022
Topic Review
Pathogenetic Mechanisms of Hypertension–Brain-Induced Complications
Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation.
  • 512
  • 09 Mar 2022
Topic Review
Economic Burden of Stroke Disease
Globally, one of the main causes of non-communicable disease as a cause of death every year is stroke. The objective of this study was to analyze the burden in consequence of stroke. 
  • 512
  • 06 Aug 2021
Topic Review
Concussion Guidelines in Amateur Sports
It is widely recognised in sports medicine that sports-related concussion (SRC) is one of the most difficult injuries to detect, with more needed to be done to recognise, remove and treat athletes with the condition
  • 511
  • 29 Mar 2022
Topic Review
Roles of Calcium Ions in Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the loss of dopaminergic neurons, which results in motor impairment.  Ca2+ homeostasis disruption and mitochondrial dysfunction play a vital role in PD aetiology. In addition, the L-type voltage-gated calcium channel is expressed at high levels amongst nigral neurons, and could play a role in the pathogenesis of PD. In the dopaminergic neurons, Ca2+ entry through plasma membrane Cav1 channels drives a sustained feed-forward stimulation of mitochondrial oxidative phosphorylation. The R-type calcium channel is a type of voltage-dependent calcium channel. Available findings suggest that calcium homeostasis in dopaminergic neurons might be a valuable target for developing new drugs for PD patients.
  • 511
  • 07 Nov 2022
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