Topic Review
Parental Needs and QoL in Children with Pompe Disease
Pompe disease (PD) is a rare metabolic disorder with progressive neuromuscular consequences that negatively impact a child’s development and quality of life (QoL). Despite an improved prognosis with treatment, the risk for early death due cardiorespiratory crisis remains. Parents not only face physical fatigue and family distress in coping with the child’s special needs but also experience emotions, worries, and unexpressed needs (a “humanistic burden”) that require supportive interventions. 
  • 36
  • 28 Mar 2024
Topic Review
Vaginal Infections and Treatment
Vaginal infections are a global public health issue affecting worldwide up to 70% of women of reproductive age. The symptoms or clinical manifestations are itching, irritation, abnormal vaginal discharge, and discomfort when urinating and during sexual activity.
  • 159
  • 26 Mar 2024
Topic Review
Training provided to Paramedics in Low-Acuity Clinical Conditions
Ambulance services around the world are increasingly attending to calls for non-emergency conditions. These lower-acuity conditions do not always require patients to be transported to the emergency department. Consequently, over the past two decades, ambulance services have implemented strategies to support paramedics in diverting non-urgent patients to alternative care pathways. However, assessing and managing low-acuity conditions can be challenging for paramedics, especially when education and training has traditionally focused on emergency care.
  • 38
  • 22 Mar 2024
Topic Review
Ontology-Based Parkinson’s Disease Monitoring and Alerting with PHKG-GNNs
In the realm of Parkinson’s Disease (PD) research, the integration of wearable sensor data with personal health records (PHR) has emerged as a pivotal avenue for patient alerting and monitoring. The complex domain of PD patient care was delved into, with a specific emphasis on harnessing the potential of wearable sensors to capture, represent and semantically analyze crucial movement data and knowledge. The primary objective is to enhance the assessment of PD patients by establishing a robust foundation for personalized health insights through the development of Personal Health Knowledge Graphs (PHKGs) and the employment of personal health Graph Neural Networks (PHGNNs) that utilize PHKGs. The objective is to formalize the representation of related integrated data, unified sensor and PHR data in higher levels of abstraction, i.e., in a PHKG, to facilitate interoperability and support rule-based high-level event recognition such as patient’s missing dose or falling. This is an extension of researchers' previous related work, presents the Wear4PDmove ontology in detail and evaluates the ontology within the development of an experimental PHKG. Furthermore, the integration and evaluation of PHKG within the implementation of a Graph Neural Network (GNN) are focused on. The importance of integrating PD-related data for monitoring and alerting patients with appropriate notifications are emphasized. These notifications offer health experts precise and timely information for the continuous evaluation of personal health-related events, ultimately contributing to enhanced patient care and well-informed medical decision-making. Finally, a novel approach for integrating personal health KGs and GNNs for PD monitoring and alerting solutions is proposed.
  • 133
  • 18 Mar 2024
Topic Review
Immunomodulatory Function of Vitamin D
Hashimoto’s thyroiditis (HT), also known as chronic autoimmune thyroiditis, is the most prevalent organ-specific autoimmune disorder. Hashimoto’s thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance.
  • 34
  • 15 Mar 2024
Topic Review
SCD and Genetic Propensity for Dementia beyond Apolipoproteinε4
Subjective cognitive decline (SCD) has been described as a probable early stage of dementia, as it has consistently appeared to precede the onset of objective cognitive impairment. SCD is related to many risk factors, including genetic predisposition for dementia. The Apolipoprotein (APOE) ε4 allele, which has been thoroughly studied, seems to explain genetic risk for SCD only partially.
  • 51
  • 14 Mar 2024
Topic Review
Gene Therapy in Duchenne Muscular Dystrophy
Gene therapy allows for the modulation and correction of specific problem genes which are mutated in severe pathologies. The term “gene therapy” is loosely defined by many sources. The FDA defines it as “products whose effects are transferred through transcription/translation of genetic material via administration as nucleic acids, viruses, or genetically engineered microorganisms”. Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle-wasting disease that results from mutations in the DMD gene on chromosome 21. Due to its poor survivorship, many interventions are being researched to improve outcomes for patients with this disease; gene therapy is an emerging field in this regard.
  • 41
  • 13 Mar 2024
Topic Review
Effect of Sex Hormones on Migraine
Sex hormones and migraine are closely interlinked. Women report higher levels of migraine symptoms during periods of sex hormone fluctuation, particularly during puberty, pregnancy, and perimenopause. Ovarian steroids, such as estrogen and progesterone, exert complex effects on the peripheral and central nervous systems, including pain, a variety of special sensory and autonomic functions, and affective processing. A panel of basic scientists, when challenged to explain what was known about how sex hormones affect the nervous system, focused on two hormones: estrogen and oxytocin.
  • 48
  • 11 Mar 2024
Topic Review
Application of Staphylococcus aureus Vaccines
Staphylococcus aureus, a prevalent human pathogen and a leading cause of hospital-acquired infections, is increasingly evolving antibiotic-resistant strains, increasing mortality and morbidity rates. Anti-staphylococcal vaccine research for prevention and treatment has become a priority. Antibodies against specific S. aureus components, toxins, and polysaccharides have demonstrated encouraging results in animal studies regarding protection against colonization or infection. However, human immunization trials have yielded less optimistic outcomes, with no anti-staphylococcal having passed clinical trials up to now. Although multiple formulation attempts triggered strong antibody responses, the vaccines could not effectively prevent S. aureus infections.
  • 97
  • 06 Mar 2024
Topic Review
Associations between Childhood Abuse and Adult Psychopathology
Research consistently shows that abuse during childhood is related to adult psychopathology. Adverse childhood experiences, including emotional, physical, and sexual abuse, have been consistently linked to mental health problems in children and adults.
  • 44
  • 05 Mar 2024
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