Topic Review
Cell of Origin and Pathogenesis of FL Transformation
The gold standard for determining follicular lymphoma (FL) transformation is based on the histologically confirmed progression of grade 1, 2, or 3A FL to a high-grade lymphoma, consisting of a predominance of large cells and the loss of the follicular architecture. Histological transformation (HT) to a more aggressive disease–mostly diffuse large B-cell lymphoma–is considered one of the most dismal events in the clinical course of FL.
  • 134
  • 27 Oct 2022
Topic Review
Combined Scientific and Artistic Approach
The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and a model for the study of the interactome due to its conserved function in the regulation of different biological processes such as immunity and development throughout the metazoan. Herein, three visual artists and a music professor collaborated with scientists for the functional characterization of the AKR2 interactome in the regulation of the NF-kB pathway in human placenta cells. The results served as a methodological proof-of-concept to advance this research area. The results showed new perspectives on unexplored characteristics of AKR2 with functional implications. These results included protein dimerization, the physical interactions with different proteins simultaneously to regulate various biological processes defined by cell type-specific AKR-protein interactions and how these interactions positively or negatively regulate the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling pathway in a biological context-dependent manner. These results suggested that AKR2 interacting proteins might constitute suitable secondary transcription factors for cell and stimulus-specific regulation of NF-kB. Musical perspective supported AKR/SUB evolutionary conservation in different species and provided new mechanistic insights into the AKR2 interactome. The combined scientific and artistic perspectives resulted in a multidisciplinary approach advancing our knowledge on AKR/SUB interactome and provided new insights into the function of AKR2-protein interactions in the regulation of the NF-kB pathway. Additionally, herein we proposed an algorithm for quantum vaccinomics by focusing on the model proteins AKR/SUB. This study was recently accepted for publication in Vaccines (Artigas-Jerónimo, S., Pastor Comín, J.J., Villar, M., Contreras, M., Alberdi, P., León Viera, I., Soto, L., Cordero, R., Valdés, J.J., Cabezas-Cruz, A., Estrada-Peña, A., de la Fuente, J. 2020. A novel combined scientific and artistic approach for advanced characterization of interactomes: the Akiri/Subolesinn model. Vaccines 8, 77)
  • 645
  • 29 Oct 2020
Topic Review
Computer Vision-Based Wood Identification
The impact of wood identification extends beyond illegal trading and ecological issues. Wood identification is paramount for the timber industry, civil and structural engineering, criminology, archaeology, art history, ethnography, and conservation and restoration, and many other disciplines.
  • 53
  • 15 Dec 2022
Topic Review
Congenital Malformations in Sea Turtles
Congenital malformations can lead to embryonic mortality in many species, and sea turtles are no exception. Genetic and/or environmental alterations occur during early development in the embryo, and may produce aberrant phenotypes, many of which are incompatible with life. Causes of malformations are multifactorial; genetic factors may include mutations, chromosomal aberrations, and inbreeding effects, whereas non-genetic factors may include nutrition, hyperthermia, low moisture, radiation, and contamination. It is possible to monitor and control some of these factors (such as temperature and humidity) in nesting beaches, and toxic compounds in feeding areas, which can be transferred to the embryo through their lipophilic properties.
  • 624
  • 22 Feb 2021
Topic Review
Corneal Sensory Nerves
The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the absence of blood and lymphatic vessels in healthy conditions, the tightly controlled hydration state, and the lack of myelinated nerves, among others. The cornea is supplied by both sensory and autonomic nerves, being one of the most densely innervated tissues in the body. Corneal innervation is anatomically organized into four levels ranging from the nerve trunks in the corneal stroma to the nerve terminals in the epithelium. Electrophysiological recordings of corneal sensory nerve fibers have revealed the existence of three different functional types of sensory neurons that are classified into mechanonociceptors, polymodal nociceptors and cold thermoreceptors depending on the modality of stimuli by which they are activated. The impulse discharge is conducted by these neurons to the central nervous system, where sensory input is processed to finally evoke a sensation and to regulate ocular protective functions, such as tearing and blinking.
  • 404
  • 21 Mar 2022
Topic Review
CRISPR/Cas-Based Approaches to Study Schizophrenia
Genomic association studies have revealed the complex genetic architecture of schizophrenia (SZ) and other neurodevelopmental disorders (NDDs). High-throughput models, such as cells and their derivatives, are needed to decipher the molecular basis of SZ pathology. The time is coming for high-throughput genetic technologies based on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas systems to manipulate multiple genomic targets. CRISPR/Cas tools make it possible to find and explore the complex relationship between genotype and phenotype of neuronal cells.
  • 44
  • 29 Dec 2022
Topic Review
Dendritic Cells and Dentinogenesis
Using several in vivo designs, antigen-presenting cells, including macrophages and dendritic cells (DCs), are identified in the pulpal tissue before tertiary dentin deposition under the afflicted area. However, the precise nature of this phenomenon and its relationship to inherent pulp cells are not yet clarified. This literature review aims to discuss the role of pulpal DCs and their relationship to progenitor/stem cells, odontoblasts or odontoblast-like cells, and other immunocompetent cells during physiological and pathological dentinogenesis.
  • 295
  • 13 Aug 2021
Topic Review
Documented Skeletal Collections in the United States
In the US, documented skeletal collections are a collective of human skeletons that originated (mostly) from body donations, human taphonomy facilities (e.g., the William M. Bass Donated Skeletal Collection), and anatomical dissections (e.g., Robert J. Terry Anatomical Collection). These collections are a major asset in the testing and development of methods used to infer the biological profile of human remains.
  • 432
  • 19 Apr 2022
Topic Review
Drugs Targeting Cancer Cells with Splicing Factor Mutations
Splicing factors are frequently mutated in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations are presumed to contribute to oncogenic transformation, but the underlying mechanisms remain incompletely understood. While no specific treatment option is available for MDS/AML patients with spliceosome mutations, novel targeting strategies are actively explored, leading to clinical trials of small molecule inhibitors that target the spliceosome, DNA damage response pathway, and immune response pathway. 
  • 84
  • 05 Sep 2022
Topic Review
ECM decellularization methods
The extracellular matrix (ECM) is a complex network with multiple functions, including specific functions during tissue regeneration. Precisely, the properties of the ECM have been thoroughly used in tissue engineering and regenerative medicine research, aiming to restore the function of damaged or dysfunctional tissues. Tissue decellularization is gaining momentum as a technique to obtain potentially implantable decellularized extracellular matrix (dECM) with well-preserved key components. Interestingly, the tissue-specific dECM is becoming a feasible option to carry out regenerative medicine research, with multiple advantages compared to other approaches. We recently published an overview of the most common methods used to obtain the dECM from specific tissues[1]. Here we provide a summary from that report as a helpful guide for future research development.
  • 1300
  • 25 Aug 2020
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