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Trending Methods for Rapid Cannabinoids Detection
Roadside testing of illicit drugs such as tetrahydrocannabinol (THC) requires simple, rapid, and cost-effective methods. The need for non-invasive detection tools has led to the development of selective and sensitive platforms, able to detect phyto- and synthetic cannabinoids by means of their main metabolites in breath, saliva, and urine samples. One may estimate the time passed from drug exposure and the frequency of use by corroborating the detection results with pharmacokinetic data. Modified surfaces can also act as filters that allow only the target analyte to participate in the electrode reaction. In the case of cannabinoids, as in the case of other drugs, the investigation of the mechanism of action within the organism is the basis of biosensor development.
18 Nov 2022
Torsion-Resistant Nature-Inspired Structures
The complexity of torsional load, its three-dimensional nature, its combination with other stresses, and its disruptive impact make torsional failure prevention an ambitious goal. However, even if the problem has been addressed for decades, a deep and organized treatment is still lacking in the actual research landscape. For this reason, this review aims at presenting a methodical approach to address torsional issues starting from a punctual problem definition. Accidents and breaks due to torsion, which often occur in different engineering fields such as mechanical, biomedical, and civil industry are considered and critically compared. More in depth, the limitations of common-designed torsion-resistant structures (i.e., high complexity and increased weight) are highlighted, and emerge as a crucial point for a deeper nature-driven analysis of novel solutions. In this context, an accurate screening of torsion-resistant bio-inspired unit cells is presented, taking inspiration specifically from plants, that are often subjected to the torsional effect of winds. As future insights, the actual state of technology suggests an innovative transposition to the industry: these unit cells could be prominently implied to develop novel metamaterials that could be able to address the torsional issue with a multi-scale and tailored arrangement.
09 Oct 2021
Thymoquinone in Chemotherapy
Thymoquinone (2-Isopropl-5-methyl benzo-1,4-quinone) is an active component of the volatile oil of Nigella sativa (black seeds). Other than the Ranunculaceae family (N. sativa), this compound has been detected in other families such as Lamiaceae (Modernadidyma, M. menthifolia, etc.), Asteraceae (Eupatorium cannabinum), and Cupressaceae (Juniperus communis).
07 Jan 2022
Thiazolidinediones (TZDs) are a kind of DMII drug. The data revealed that compounds (4–6) have higher potency than the reference drugs. Compounds (4–7) were able to regulate hyperlipidemia levels (cholesterol, triglyceride, high-density lipoproteins and low- and very-low-density lipoproteins) to nearly normal value at the 30th day.
29 Jan 2022
The Rearrangement of Alkylallenes to 1,3-Dienes
1,3-Dienes are vital building blocks in organic synthesis. They underpin many fundamental synthetic transformations and are present in numerous natural products and drug candidate molecules.
19 Jan 2022
Thallium, as a pharmaceutical cosmetic product, is applied for facial hair removal and fungal infections of the scalp. Thallium acetate is currently used as a catalyst in organic synthesis in the oxidation of olefins and hydrocarbons, and in epoxidation and polymerization reactions. Detection of Tl is a challenging task because its concentration in environmental samples may be at a nanogram per gram level or lower.
23 Nov 2021
Tetrazine-Based Fluorogenic Probes
Various bioorthogonal chemistries have been used for fluorescent imaging owing to the advantageous reactions they employ. Recent advances in bioorthogonal chemistry have revolutionized labeling strategies for fluorescence imaging, with inverse electron demand Diels–Alder (iEDDA) reactions in particular attracting recent attention owing to their fast kinetics and excellent specificity. One of the most interesting features of the iEDDA labeling strategy is that tetrazine-functionalized dyes are known to act as fluorogenic probes.
13 Apr 2021
Terpene Mini-Path for Terpenoids Bio-Production
Terpenoids constitute the largest class of natural compounds and are extremely valuable from an economic point of view due to their extended physicochemical properties and biological activities. An alternative to produce terpenoids is the use of biotechnological tools involving, for example, the construction of enzymatic cascades (cell-free synthesis) or a microbial bio-production thanks to metabolic engineering techniques.
22 Dec 2021
Synthetic Applications of Lawesson’s Reagent in Organic Synthesis
Lawesson’s reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days. Now its use can help the chemistry community to understand innovative ideas. These include constructing biologically valuable heterocycles, coupling reactions, and the thionation of natural compounds.
27 Nov 2021
Synthesis of Quantum Dots, Polymer, and Nanocomposites
Owing to the nanometer size range, Quantum Dots (QDs) have exhibited unique physical and chemical properties which are favourable for different applications. Especially, due to their quantum confinement effect, excellent optoelectronic characteristics is been observed. This considerable progress has not only uplifted the singular usage of QDs, but also encouraged to prepare various hybrid materials to achieve superior efficiency by eliminating certain shortcomings. Such issues can be overcome by compositing QDs with polymers.
14 Apr 2022
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Encyclopedia of Social Sciences
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