Topic Review
Neuroprotective Potential of Cordyceps Extracts
Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. 
  • 54
  • 01 Mar 2024
Topic Review
Severe Falciparum Malaria
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary beds of organs and tissues. This sequestration is due to the cytoadherence of infected erythrocytes to endothelial cells.
  • 155
  • 02 Aug 2023
Topic Review
Aetiology and Pathogenesis of Vitiligo
Vitiligo is an acquired, chronic condition characterised by depigmentation of the epidermis or by destruction/loss of melanin. Skin cells (melanocytes) are responsible for producing melanin, the substance that gives pigmentation to the skin. Although there is no specific ethnic group, gender, or skin type that is more prone to vitiligo than others, it can affect anyone. Even though vitiligo is typically thought of as a cosmetic disorder, its effects on the physical and psychosocial health of sufferers cannot be ignored.
  • 222
  • 09 Jun 2023
Topic Review
Control Strategies for Mosquito-Borne Diseases
Mosquito-borne diseases are spread by the bite of infected female mosquitoes. The main mosquito-borne diseases include malaria, Chikungunya, Zika, Dengue, West Nile, yellow fever, Rift Valley fever, Lymphatic filariasis, and tick-borne encephalitis. Various chemical, biological, and mechanical methods are used to control mosquito-borne diseases hence reducing their burden.
  • 186
  • 13 Mar 2023
Topic Review
Phytoextracts as Crop Biostimulants and Natural Protective Agents
Plants are the basic source of food, energy and dietary fibers for mankind. However, the production of cereal crops affected due to various biotic and abiotic factors due to anthropogenic activities. Fungal pathogens are responsible for plant diseases and cause high economic losses. Synthetic fungicides, which are toxic and harmful to the environment, are used to control plant diseases caused by fungal pathogens; the trend is shifting towards healthy, safe and sound ecofriendly control of fungal pathogens. Phytoextracts of Beta vulgaris, Moringa oleifera, Citrus sinensis, Melia azedarach and Azadirachta indica significantly inhibited the fungal growth and spore germination.
  • 425
  • 17 Nov 2022
Topic Review
Australian Tropical Medicinal Plants
Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants.
  • 659
  • 01 Jul 2022
Topic Review
Microbiota of Sand Flies
Sand flies are a significant public health concern in many parts of the world where they are known to transmit agents of several zoonotic diseases to humans, such as leishmaniasis. Vector control remains a key component of many anti-leishmaniasis programs and probably will remain so until an effective vaccine becomes available. The sand fly gut microbiota has emerged as an encouraging field for the exploration of vector-based disease control. In particular, the gut microbiome was previously reported to either enhance or inhibit parasite activity depending on the species of bacteria and, thus, has the potential to alter vector competence. 
  • 580
  • 17 Jun 2022
Topic Review
Isatin-Based Scaffolds
Isatin, chemically an indole-1H-2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in trials. Apart from its promising antiproliferative properties, isatin has shown potential in treating Neglected Tropical Diseases (NTDs) not only as a parent core, but also by attenuating the activities of various pharmacophores.
  • 507
  • 06 May 2022
Topic Review
Tranditional Use and Nutritional Value of Lansium domesticum
Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines.
  • 1.5K
  • 21 Apr 2022
Topic Review Peer Reviewed
Generational Effects of Opioid Exposure
The inheritance of substance abuse, including opioid abuse, may be influenced by genetic and non-genetic factors related to the environment, such as stress and socioeconomic status. These non-genetic influences on the heritability of a trait can be attributed to epigenetics. Epigenetic inheritance can result from modifications passed down from the mother, father, or both, resulting in either maternal, paternal, or parental epigenetic inheritance, respectively. These epigenetic modifications can be passed to the offspring to result in multigenerational, intergenerational, or transgenerational inheritance. Human and animal models of opioid exposure have shown generational effects that result in molecular, developmental, and behavioral alterations in future generations. 
  • 679
  • 13 Apr 2022
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