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Topic Review
Lysosomal-Cleavable Peptide Linkers in Antibody–Drug Conjugates
Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an effector payload molecule via a linker. The success of currently used ADCs has been largely attributed to the development of linker systems, which allow for the targeted release of cytocidal payload drugs inside cancer cells.
  • 3.9K
  • 02 Feb 2024
Topic Review
Citric Acid for Wood Modification
Citric acid (CA) can be found naturally in fruits and vegetables, particularly citrus fruit. CA is widely used in many fields but its usage as a green modifying agent and binder for wood is barely addressed. Esterification is one of the most common chemical reactions applied in wood modification. CA contains three carboxyl groups, making it possible to attain at least two esterification reactions that are required for crosslinking when reacting with the hydroxyl groups of the cell wall polymers. In addition, the reaction could form ester linkages to bring adhesivity and good bonding characteristics, and therefore CA could be used as wood binder too. The environmental impacts and future outlook of CA-treated wood and bonded composite are considered.
  • 3.9K
  • 31 Jul 2020
Topic Review
Social Constructionism
Social constructionism is a theoretical approach in sociology that posits that reality is socially constructed through language, discourse, and social interactions. It asserts that knowledge and meaning are not inherent in objects or phenomena but are instead created and maintained by individuals and societies through shared beliefs, cultural norms, and power dynamics. Social constructionism emphasizes the role of language, symbols, and social context in shaping our understanding of reality and social phenomena.
  • 3.9K
  • 26 Jan 2024
Topic Review
Moment
In physics, a moment is a mathematical expression involving the product of a distance and physical quantity. Moments are usually defined with respect to a fixed reference point and refer to physical quantities located some distance from the reference point. In this way, the moment accounts for the quantity's location or arrangement. For example, the moment of force, often called torque, is the product of a force on an object and the distance from the reference point to the object. In principle, any physical quantity can be multiplied by a distance to produce a moment. Commonly used quantities include forces, masses, and electric charge distributions.
  • 3.9K
  • 07 Nov 2022
Topic Review
Sensors for Hydrogen Peroxide Detection
 Hydrogen peroxide (H2O2) is a key molecule in numerous physiological, industrial, and environmental processes. H2O2 is monitored using various methods like colorimetry, luminescence, fluorescence, and electrochemical methods. Here, we aim to provide a comprehensive review of solid state sensors to monitor H2O2. The review covers three categories of sensors: chemiresistive, conductometric, and field effect transistors. A brief description of the sensing mechanisms of these sensors has been provided. All three sensor types are evaluated based on the sensing parameters like sensitivity, limit of detection, measuring range and response time. We highlight those sensors which have advanced the field by using innovative materials or sensor fabrication techniques. Finally, we discuss the limitations of current solid state sensors and the future directions for research and development in this exciting area. 
  • 3.9K
  • 30 Jan 2021
Topic Review
Life Cycle Assessment in Aviation
With growing environmental awareness and the resulting pressure on aviation, ecological impact assessments are becoming increasingly important. Life cycle assessment has been widely used in the literature as a tool to assess the environmental impact of aircraft. In the following, a brief overview of the existing research on the topic of life cycle assessment in aviation is given. This is concluded with a short summary and an introduction to a possible combination with discrete-event simulation.
  • 3.9K
  • 09 Sep 2022
Topic Review
The All
The All (also called The One, The Absolute, The Great One, The Creator, The Supreme Mind, The Supreme Good, The Father, and The All Mother) is the Hermetic, pantheistic, pandeistic or panentheistic (and thus also panpsychism/monopsychism/unus mundus/anima mundi) view of God, which is that everything that is, or at least that can be experienced, collectively makes up The All. One Hermetic maxim states, "While All is in The All, it is equally true that The All is in All." The All can also be seen to be androgynous, possessing both masculine and feminine qualities in equal part.
  • 3.9K
  • 18 Oct 2022
Topic Review
Stoat
The Stoat (Mustela erminea), also known as the short-tailed weasel, is a small carnivorous mammal belonging to the Mustelidae family. Characterized by its slender body, short legs, and distinctive white winter coat with a black-tipped tail, the stoat is found in various habitats across North America, Europe, and Asia. As an agile predator, the stoat preys on a wide range of small mammals, birds, and insects, utilizing its keen senses and swift movements to hunt and capture its prey.
  • 3.9K
  • 15 Mar 2024
Topic Review
GeForce 900 Series
The GeForce 900 series is a family of graphics processing units developed by Nvidia, succeeding the GeForce 700 series and serving as the high-end introduction to the Maxwell microarchitecture, named after James Clerk Maxwell. They are produced with TSMC's 28 nm process. With Maxwell, the successor to Kepler, Nvidia expected three major outcomes: improved graphics capabilities, simplified programming, and better energy efficiency compared to the GeForce 700 series and GeForce 600 series. Maxwell was announced in September 2010, with the first Maxwell-based GeForce consumer-class products released in early 2014.
  • 3.9K
  • 17 Nov 2022
Topic Review
Visible-Light-Promoted Carbonylation Reactions
The abundant and inexpensive carbon monoxide (CO) is widely exploited as a C1 source for the synthesis of both fine and bulk chemicals. In this context, photochemical carbonylation reactions have emerged as a powerful tool for the sustainable synthesis of carbonyl-containing compounds (esters, amides, ketones, etc.).
  • 3.9K
  • 11 Aug 2021
Topic Review Peer Reviewed
Opportunities for Catalytic Reactions and Materials in Buildings
Residential and commercial buildings are responsible for over 30% of global final energy consumption and accounts for ~40% of annual direct and indirect greenhouse gas emissions. Energy efficient and sustainable technologies are necessary to not only lower the energy footprint but also lower the environmental burden. Many proven and emerging technologies are being pursued to meet the ever-increasing energy demand. Catalytic science has a significant new role to play in helping address sustainable energy challenges, particularly in buildings, compared to transportation and industrial sectors. Thermally driven heat pumps, dehumidification, cogeneration, thermal energy storage, carbon capture and utilization, emissions suppression, waste-to-energy conversion, and corrosion prevention technologies can tap into the advantages of catalytic science in realizing the full potential of such approaches, quickly, efficiently, and reliably. Catalysts can help increase energy conversion efficiency in building related technologies but must utilize low cost, easily available and easy-to-manufacture materials for large scale deployment. This entry presents a comprehensive overview of the impact of each building technology area on energy demand and environmental burden, state-of-the-art of catalytic solutions, research, and development opportunities for catalysis in building technologies, while identifying requirements, opportunities, and challenges.
  • 3.9K
  • 18 Apr 2022
Topic Review
Bioemulsifiers and Its Applications in Food Industry
Bioemulsifiers have a larger molecular weight than biosurfactants, because they are complex mixes of lipopolysaccharides, lipoproteins, heteropolysaccharides, and proteins. Due to their functional capabilities and eco-friendly properties, bioemulsifiers (BE) are regarded as multifunctional biomolecules of the twenty-first century. Numerous microorganisms produce bioemulsifiers under a variety of diverse and extreme environmental conditions. Bioemulsifiers are widely used in a variety of industries, including medicine, petroleum, food, pharmaceuticals, chemicals, textiles, and cosmetics.
  • 3.9K
  • 12 Jul 2022
Topic Review
Five-Minute Speech Sample for High Expressed Emotion
Expressed Emotion (EE) describes the tone of a caregiver’s response to a patient with a mental disorder, and it is used to predict relapse. The Five-Minute Speech Sample (FMSS) is a 5-min interview with a caregiver that evaluates only two EE dimensions. The FMSS emerged as a valid and reliable tool for measuring EE as a predictor of relapse in patients with schizophrenia and major depressive disorder. Patient age and duration of illness had no significant effect on the results. Future meta-analyses should include more studies to reduce publication bias. EE may be a good predictor of relapse when examined through a fast measurement technique such as the FMSS, which may also be useful to analyze the psychopathological structure of caregivers. 
  • 3.9K
  • 18 Jan 2023
Topic Review
Research on COVID-19
As of March, most of the world is under the order of a “lockdown” or “restricted movement control” whereby world leaders and medical experts believe that social isolation is the best option at reducing the spread of the highly infectious and novel disease, that is Coronavirus Disease (COVID-19). While this preventive measure is in place, various diagnostic kits and treatment strategies are being researched daily to diagnose and curb this disease quickly. This report summarizes the characteristics of the SARS-CoV-2 virus and evaluates the diagnostic kits and treatment drugs as well as vaccines that are either currently being used (RT-PCR) or in the clinical pipeline for safety and efficacy testing, respectively. The sooner efficient diagnosis and treatment can be made, the greater the number of lives will be saved.
  • 3.9K
  • 30 Oct 2020
Topic Review
Energetic Valorisation of Olive Biomass
The generation, composition, properties and potential energetic applications of the main three biomass obtained from the olive oil industry are illustrated.
  • 3.9K
  • 27 Oct 2020
Topic Review
The Mesoporous Silica Nanoparticles
Mesoporous silica nanoparticles (MSNs) are a porous inorganic framework synthesized using the inorganic silica sources sodium silicates or silica tetraethyl orthosilicate as a precursor with quaternary ammonium salts as the surfactant. The size and porosity of MSNs are regulated by various factors such as surfactants, the source of silica, ion strength, aging duration, temperature, and pH. Highly ordered mesoporous silica came into the limelight after the fabrication of the silica-based material Mobile crystalline material 41 (MCM) by Kazuyuki Kuroda’s groups and scientists at Mobil Oil Corporation from aluminium silicate gel. MSNs have a unique porous solid framework with a large surface area facilitating functionalization with various functional groups for targeted drug delivery. MCM-41, MCM-48, and SBA-15 are the most common mesoporous silica materials with two-dimensional hexagonal and three-dimensional cubic structures possessing pore sizes of 2–10 nm.
  • 3.9K
  • 06 May 2023
Topic Review
Road Traffic Congestion
Traffic congestion is a perpetual problem for the sustainability of transportation development. Traffic congestion causes delays, inconvenience, and economic losses to drivers, as well as air pollution. Identification and quantification of traffic congestion are crucial for decision-makers to initiate mitigation strategies to improve the overall transportation system’s sustainability. This study summarizes the current road traffic congestion measures and provides a constructive insight into the development of a sustainable and resilient traffic management system.
  • 3.9K
  • 27 Oct 2020
Topic Review
Pseudomonas aeruginosa
Pseudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients. seudomonas aeruginosa is the most frequent cause of infection among non-fermenting Gram-negative bacteria, predominantly affecting immunocompromised patients, but its pathogenic role should not be disregarded in immunocompetent patients.
  • 3.9K
  • 21 Jan 2021
Topic Review
Yucca schidigera in Aquaculture
In modern aquaculture systems, farmers are increasing the stocking capacity of aquatic organisms to develop the yield and maximize water resources utilization. However, the accumulation of ammonia in fishponds regularly occurs in intensive aquaculture systems, resulting in reduced growth rates and poor health conditions. The inclusion of yucca extract is recognized as a practical solution for adsorbing the waterborne ammonia. Yucca has abundant amounts of polyphenolics, steroidal saponins, and resveratrol and can be used as a solution or as a powder.
  • 3.9K
  • 06 Mar 2021
Topic Review
Sol-gel Technology for Commercial Coatings
The commercial availability of inorganic/organic precursors for sol-gel formulation is very high and increase day by day. By using the sol-gel technology, it is possible to provide materials with functional/multi-functional characteristics including flame retardant, anti-mosquito, water-repellent oil-repellent, anti-bacterial, anti-wrinkle, ultraviolet (UV) protection, self-cleaning and other properties. Some of these properties are discussed here, describing basic chemistry, factors affecting the sol-gel process, as well as progress and parameters controlling sol-gel technology for thin coatings.
  • 3.9K
  • 29 Apr 2021
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