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Topic Review
Friction Stir Processing
Friction stir processing (FSP) is a material processing technique developed in 1999 derived from friction stir welding (FSW). Developed by Mishra et al., this process utilizes localized plastic deformation by rotating a specialized pin through the working piece. 
  • 4.0K
  • 22 Sep 2021
Topic Review
Phenolic Compounds and Its Linkage
Medicinal plants, along with cereals, fruits, herbs, and vegetables, are the main sources of phenolic compounds, of which nearly 10,000 have been reported in nature to date. They are secondary metabolites produced by plants to protect them from abiotic factors (e.g., drought, extreme temperatures, floods, heavy metals, pH, radiation, salinity, and soils) and biotic factors, such as animals and pathogens attack.
  • 4.0K
  • 29 Apr 2022
Topic Review
Web Search Engine
A web search engine or Internet search engine is a software system that is designed to carry out web search (Internet search), which means to search the World Wide Web in a systematic way for particular information specified in a textual web search query. The search results are generally presented in a line of results, often referred to as search engine results pages (SERPs). The information may be a mix of links to web pages, images, videos, infographics, articles, research papers, and other types of files. Some search engines also mine data available in databases or open directories. Unlike web directories, which are maintained only by human editors, search engines also maintain real-time information by running an algorithm on a web crawler. Internet content that is not capable of being searched by a web search engine is generally described as the deep web.
  • 4.0K
  • 19 Oct 2022
Topic Review
Memory Span
In psychology and neuroscience, memory span is the longest list of items that a person can repeat back in correct order immediately after presentation on 50% of all trials. Items may include words, numbers, or letters. The task is known as digit span when numbers are used. Memory span is a common measure of working memory and short-term memory. It is also a component of cognitive ability tests such as the WAIS. Backward memory span is a more challenging variation which involves recalling items in reverse order.
  • 4.0K
  • 20 Oct 2022
Topic Review
SoftEther VPN
SoftEther VPN is free open-source, cross-platform, multi-protocol VPN client and VPN server software, developed as part of Daiyuu Nobori's master's thesis research at the University of Tsukuba. VPN protocols such as SSL VPN, L2TP/IPsec, OpenVPN, and Microsoft Secure Socket Tunneling Protocol are provided in a single VPN server. It was released using the GPLv2 license on January 4, 2014. The license was switched to Apache License 2.0 on January 21, 2019. SoftEther VPN supports NAT traversal, making it useful to run VPN servers on computers that are behind residential gateways, facility routers, and firewalls. Firewalls performing deep packet inspection are unable to detect SoftEther's VPN transport packets as a VPN tunnel because HTTPS is used to camouflage the connection. SoftEther VPN optimizes performance by using full Ethernet frame utilization, reducing memory copy operations, parallel transmission, and clustering. Together, these reduce latency normally associated with VPN connections while increasing throughput. The SoftEther VPN Server is unable to bind to specific IP addresses on a machine, negating one of its biggest features. A server running an SSL website cannot run SoftEther on the same machine, thereby preventing it from using the SSL-VPN tunnel functionality that the software is famous for.
  • 4.0K
  • 30 Oct 2022
Topic Review
Dead Space (Video Game)
Dead Space is a 2008 survival horror video game developed by EA Redwood Shores and published by Electronic Arts for the PlayStation 3, Xbox 360 and Microsoft Windows. Released in October 2008, the title was the first in the Dead Space franchise and drew inspiration from other works of horror, notably Resident Evil 4 and the Silent Hill series. Set on a mining spaceship overrun by monsters called Necromorphs, the player controls engineer Isaac Clarke from the third-person perspective as he navigates the spaceship, fights Necromorphs, and struggles with increasing psychosis. The player explores areas on the station through the narrative, solving environmental puzzles while finding ammunition and equipment to survive. Isaac wields engineering equipment as weapons. Dead Space was pitched in early 2006 and fit Electronic Arts' priority of creating new intellectual properties. A prototype of the game was developed for the original Xbox console and lasted 18 months. The team aimed for realism and innovation in design. In the pursuit of these goals, the team removed set spawn points for enemies and omitted the heads-up display in favor of presenting information in the world. Immersive and frightening sound design was a large priority during production, and the score by Jason Graves was noted by critics cause of evoke tension and unease. Dead Space debuted weak in sales but eventually sold over a million copies worldwide. The game was met with universal acclaim: reviewers praised its atmosphere, gameplay and sound design. It won and was nominated for multiple industry awards and has been ranked by journalists as one of the greatest video games ever made. To following of the game success, spawned an adaptation for mobile phones, two numbered sequels (released in 2011 and 2013), several spin-off titles, and other related media, including a comic book prequel and an animated film. A remake of Dead Space is currently in development by EA's Motive Studios that set for release in early 2023.
  • 4.0K
  • 14 Oct 2022
Topic Review
Himbo
Himbo, a portmanteau of the words him and bimbo, is a slang term for an attractive but vacuous man. The word was first used in 1988. Since then, the term and the stereotype it describes have generated a range of commentary and reactions from writers, entertainers, linguists, and cultural analysts.
  • 4.0K
  • 04 Nov 2022
Topic Review
Muscle Memory
Muscle memory is a form of procedural memory that involves consolidating a specific motor task into memory through repetition, which has been used synonymously with motor learning. When a movement is repeated over time, a long-term muscle memory is created for that task, eventually allowing it to be performed with little to no conscious effort. This process decreases the need for attention and creates maximum efficiency within the motor and memory systems. Muscle memory is found in many everyday activities that become automatic and improve with practice, such as riding bicycles, driving motor vehicles, playing ball sports, typing on keyboards, entering PINs, playing musical instruments, poker, martial arts, and dancing.
  • 4.0K
  • 04 Nov 2022
Topic Review
Graphic Communication
Graphic communication as the name suggests is communication using graphic elements. These elements include symbols such as glyphs and icons, images such as drawings and photographs, and can include the passive contributions of substrate, color and surroundings. It is the process of creating, producing, and distributing material incorporating words and images to convey data, concepts, and emotions. The field of graphic communications encompasses all phases of the graphic communications processes from origination of the idea (design, layout, and typography) through reproduction, finishing and distribution of two- or three-dimensional products or electronic transmission.
  • 4.0K
  • 13 Oct 2022
Topic Review
Mode-locking
Mode-locking is a technique in optics by which a laser can be made to produce pulses of light of extremely short duration, on the order of picoseconds (10−12 s) or femtoseconds (10−15 s). A laser operated in this way is sometimes referred to as a femtosecond laser, for example in modern refractive surgery. The basis of the technique is to induce a fixed-phase relationship between the longitudinal modes of the laser's resonant cavity. Constructive interference between these modes can cause the laser light to be produced as a train of pulses. The laser is then said to be 'phase-locked' or 'mode-locked'.
  • 4.0K
  • 03 Nov 2022
Topic Review
Cobalt-Chromium Dental Alloys
The processing of Co–Cr alloys by melting and casting in refractory molds remains a viable method that can support innovation, in the context of technology advance in recent years towards digitalization of the manufacturing process, i.e., the construction of prosthetic frameworks conducted by additive methods using Co–Cr powder alloy.
  • 4.0K
  • 28 Jun 2022
Topic Review
Mitogen-Activated Protein Kinases (MAPKs)
Kinases are considered the largest protein family in the human proteome, and approximately 2% of eukaryotic genes encode kinase superfamily members. These enzymes catalyze the transference of the γ-phosphate from ATP to serine, threonine, or tyrosine amino acid residues of a downstream protein substrate, creating a communication cascade that is fundamental to eukaryotic cells. 
  • 4.0K
  • 26 Apr 2021
Topic Review
XPS Analysis of Carbon Materials
The surface chemistry of carbon materials is predominantly explored using x-ray photoelectron spectroscopy (XPS). However, many journal articles have critical failures in the published analysis which typically stems from an ill-informed approach to analyzing the spectroscopic data. The presented work presents a discussion on lineshapes and associated changes in the spectral envelope of predominantly graphitic materials, which together with the use of the D-parameter to verify levels of the graphitic content, using this information to highlight a simple and logical approach to strengthen confidence in the functionalization derived from the carbon core-level spectra.
  • 4.0K
  • 16 Jul 2021
Topic Review
Melatonin: ATP Regulation in MLOs
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic, chemically distinct subcellular compartments organizing macromolecules such as proteins, RNA, and DNA in unicellular prokaryotic bacteria and complex eukaryotic cells. Separated from surrounding environments, MLOs in the nucleoplasm, cytoplasm, and mitochondria assemble by liquid–liquid phase separation (LLPS) into transient, non-static, liquid-like droplets that regulate essential molecular functions. LLPS is primarily controlled by ATP-dependent post-translational modifications (PTMs) that fine-tune the balance between attractive and repulsive charge states and/or binding motifs of proteins. Aberrant phase separation due to the absence of adequate hydrotropic small molecules such as ATP can cause pathological protein aggregation in diseases such as neurodegenerative disorders. Melatonin is a potent antioxidant capable of protecting cardiolipin and membrane lipids raft domains from peroxidation to support ATPase functionality and ion channel activities that may exert a dominant influence over phase separation in biomolecular condensates during condensate coacervation or dissolution processes that are ATP-dependent. 
  • 4.0K
  • 30 Sep 2021
Topic Review
Smart City Applications
Smart city applications are designed to take advantage of the smart city ICT and collected data to provide value-added smart features. These applications use data analytics, intelligent techniques and other advanced technologies to make smart decisions that improve the smart city's operations and quality of life.
  • 4.0K
  • 17 Dec 2021
Topic Review
The Impact of Regulatory Pressures on Governance
abstract: Purpose: With this paper, we aim to provide an insight on the regulatory reforms on corporate governance, brought about, by its ineffectiveness in the global financial crisis. Design/Approach/Methodology: To this effect we compared accounting ratios over a period of 10 years - 5 years prior and during financial crisis (i.e. 2006-2010) and 5-years post regulatory reforms on governance (i.e. 2014-2018) -using panel data of ratios for profitability, liquidity and efficiency. Findings: The general trend in the banks was that profitability and efficiency decreased drastically in the post regulatory period, contrary to liquidity, which increased, as higher capital buffers were imposed on banks. Practical Implications: This study is important because the burden of regulations is detrimental to the performance of public banks in the EU Mediterranean region. There are several arguments that the burden of compliance is becoming very costly and this is negatively affecting their profitability and efficiency. Originality/Value: These findings are of interest to economists and policymakers within the European Mediterranean region. Keywords: Governance, regulations on governance, changes in regulations, performance, financial crisis, governance and performance. JEL code: G21, G28.
  • 4.0K
  • 28 May 2020
Topic Review
Methicilin-Susceptible Staphylococcus aureus
Antibiotic resistance is a global health challenge nowadays, and methicillin-sensitive Staphylococcus aureus (MSSA) is a skin infection presents as pimples, boils, abscesses, or infected cuts and is not resistant to certain antibiotics. MSSA affects people of all ages and is known to cause epidemics among sports teams, families, prison inmates, and people who live and work in close quarters and is a global health challenge nowadays, creating problems in antibiotic therapy.
  • 4.0K
  • 10 Nov 2020
Topic Review
O-Linked Glycosylation
O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O-glycosylation is a post-translational modification that occurs after the protein has been synthesised. In eukaryotes, it occurs in the endoplasmic reticulum, Golgi apparatus and occasionally in the cytoplasm; in prokaryotes, it occurs in the cytoplasm. Several different sugars can be added to the serine or threonine, and they affect the protein in different ways by changing protein stability and regulating protein activity. O-glycans, which are the sugars added to the serine or threonine, have numerous functions throughout the body, including trafficking of cells in the immune system, allowing recognition of foreign material, controlling cell metabolism and providing cartilage and tendon flexibility. Because of the many functions they have, changes in O-glycosylation are important in many diseases including cancer, diabetes and Alzheimer's. O-glycosylation occurs in all domains of life, including eukaryotes, archaea and a number of pathogenic bacteria including Burkholderia cenocepacia, Neisseria gonorrhoeae and Acinetobacter baumannii.
  • 4.0K
  • 25 Nov 2022
Topic Review
Rabbit Meat Production
Rabbit meat could play an important role in health, the rural economy, and sustainable development. Rabbit meat has excellent nutritional features, such as high protein content, low-fat content, and a high percentage of unsaturated fatty acids, low cholesterol and sodium levels. In addition, rabbit meat production contributes to maintaining economic activities in rural marginal areas.
  • 4.0K
  • 10 Feb 2023
Topic Review
Thyroid and Heart
The thyroid–heart relationship has a long and articulated history of its own, a history that encompasses physiological and pathophysiological knowledge. Molecular biology studies, in an experimental context, have highlighted the extraordinary dialogue that exists among the two systems in the field of cardioprotection, which is an extremely important area for the treatment of cardiac diseases in both acute and chronic phases. In addition, in the last few years, several studies have been carried out on the prognostic impact of alterations in thyroid function, including subclinical ones, in heart disease, in particular in heart failure and acute myocardial infarction, with evidence of a negative prognostic impact of these and, therefore, with the suggestion to treat these alterations in order to prevent cardiac events, such as death.  A comprehensive summary of the heart–thyroid relationship is provided.
  • 4.0K
  • 03 Jan 2024
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