pyruvate dehydrogenase E1 beta subunit
The PDHB gene provides instructions for making a protein called E1 beta. E1 beta is a piece (a subunit) of a larger protein: two E1 beta proteins combine with two copies of another protein, called E1 alpha (produced from the PDHA1 gene), to form the E1 enzyme. This enzyme, also known as pyruvate dehydrogenase, is a component of a group of proteins called the pyruvate dehydrogenase complex.
The pyruvate dehydrogenase complex plays an important role in the pathways that convert the energy from food into a form that cells can use. This complex converts a molecule called pyruvate, which is formed from the breakdown of carbohydrates, into another molecule called acetyl-CoA. The E1 enzyme performs one part of this chemical reaction. The conversion of pyruvate is essential to begin the series of chemical reactions that produces adenosine triphosphate (ATP), the cell's main energy source.
2. Health Conditions Related to Genetic Changes
2.1. Pyruvate dehydrogenase deficiency
Mutations in the PDHB gene are a very rare cause of pyruvate dehydrogenase deficiency. This condition is characterized by a potentially life-threatening buildup of a chemical called lactic acid in the body (lactic acidosis), delayed development, and neurological problems. These mutations change single protein building blocks (amino acids) in the E1 beta protein, resulting in an abnormal E1 beta protein that cannot function properly. The abnormal protein may not be able to interact with E1 alpha to form the E1 enzyme or with other factors needed for the E1 enzyme to perform its chemical reaction. A decrease of functional E1 beta leads to a reduction of pyruvate dehydrogenase complex activity. With decreased function of this complex, pyruvate builds up and is converted, in another chemical reaction, to lactic acid, causing lactic acidosis. In addition, the production of cellular energy is diminished. The brain, which is especially dependent on this form of energy, is severely affected, resulting in the neurological problems associated with pyruvate dehydrogenase deficiency.
2.2. Leigh syndrome
3. Other Names for This Gene
- pyruvate dehydrogenase (lipoamide) beta
- pyruvate dehydrogenase E1 component subunit beta, mitochondrial
- pyruvate dehydrogenase, E1 beta polypeptide
The entry is from https://medlineplus.gov/genetics/gene/pdhb
- Biochemistry (fifth edition, 2002): The Formation of Acetyl Coenzyme A from Pyruvate
- Brown RM, Head RA, Boubriak II, Leonard JV, Thomas NH, Brown GK. Mutations in the gene for the E1beta subunit: a novel cause of pyruvate dehydrogenasedeficiency. Hum Genet. 2004 Jul;115(2):123-7.
- Okajima K, Korotchkina LG, Prasad C, Rupar T, Phillips JA 3rd, Ficicioglu C,Hertecant J, Patel MS, Kerr DS. Mutations of the E1beta subunit gene (PDHB) infour families with pyruvate dehydrogenase deficiency. Mol Genet Metab. 2008Apr;93(4):371-80. doi: 10.1016/j.ymgme.2007.10.135.
- Patel MS, Korotchkina LG, Sidhu S. Interaction of E1 and E3 components withthe core proteins of the human pyruvate dehydrogenase complex. J Mol Catal BEnzym. 2009 Nov 1;61(1-2):2-6.
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