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    GCDH Gene

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    Submitted by: Vivi Li
    (This entry belongs to Entry Collection "MedlinePlus ")

    Definition

    Glutaryl-CoA dehydrogenase

    1. Normal Function

    The GCDH gene provides instructions for making the enzyme glutaryl-CoA dehydrogenase. This enzyme is found in mitochondria, the energy-producing centers of cells. The GCDH enzyme is involved in the breakdown of the amino acids lysine, hydroxylysine, and tryptophan, which are building blocks of proteins.

    2. Health Conditions Related to Genetic Changes

    2.1 Glutaric Acidemia Type I

    Mutations in the GCDH gene prevent production of the glutaryl-CoA enzyme, or result in the production of a defective enzyme that cannot fulfill its role in the breakdown of lysine, hydroxylysine, and tryptophan. This enzyme deficiency allows these amino acids and their intermediate breakdown products to build up to abnormal levels, which damages the nervous system, especially when the body is under stress.

    More than 150 GCDH gene mutations that cause glutaric acidemia type I have been reported in populations around the world. Most of these mutations result in the substitution of one amino acid for another amino acid in the enzyme. In the Old Order Amish community, all known glutaric acidemia type I cases derive from the replacement of the amino acid alanine with the amino acid valine at position 421 (written as Ala421Val or A421V). A few specific mutations have been seen in certain Native American populations. Individuals with glutaric acidemia type I who belong to the Lumbee community of North Carolina have been found to have a mutation in which the amino acid glutamic acid is replaced with the amino acid lysine at position 414, written as Glu414Lys or E414K. A mutation that replaces a particular DNA building block (nucleotide) called guanine with the nucleotide thymine (written as IVS1, G-T, +5) is prevalent in the Ojibwa population of Canada. As a result of this mutation, an abnormally shortened version of the enzyme is produced. Many different mutations occur in other populations.

    3. Other Names for This Gene

    • ACAD5

    • GCD

    • GCDH_HUMAN

    • glutaryl-CoA dehydrogenase, mitochondrial

    • glutaryl-Coenzyme A dehydrogenase isoform a precursor

    • glutaryl-Coenzyme A dehydrogenase isoform b precursor

    The entry is from https://medlineplus.gov/genetics/gene/gcdh

    References

    1. Basinger AA, Booker JK, Frazier DM, Koeberl DD, Sullivan JA, Muenzer J.Glutaric acidemia type 1 in patients of Lumbee heritage from North Carolina. Mol Genet Metab. 2006 May;88(1):90-2.
    2. Busquets C, Soriano M, de Almeida IT, Garavaglia B, Rimoldi M, Rivera I, UzielG, Cabral A, Coll MJ, Ribes A. Mutation analysis of the GCDH gene in Italian and Portuguese patients with glutaric aciduria type I. Mol Genet Metab. 2000Nov;71(3):535-7.
    3. Goodman SI, Stein DE, Schlesinger S, Christensen E, Schwartz M, Greenberg CR, Elpeleg ON. Glutaryl-CoA dehydrogenase mutations in glutaric acidemia (type I):review and report of thirty novel mutations. Hum Mutat. 1998;12(3):141-4. Review.
    4. Greenberg CR, Prasad AN, Dilling LA, Thompson JR, Haworth JC, Martin B,Wood-Steiman P, Seargeant LE, Seifert B, Booth FA, Prasad C. Outcome of the first3-years of a DNA-based neonatal screening program for glutaric acidemia type 1 inManitoba and northwestern Ontario, Canada. Mol Genet Metab. 2002 Jan;75(1):70-8.
    5. Hedlund GL, Longo N, Pasquali M. Glutaric acidemia type 1. Am J Med Genet CSemin Med Genet. 2006 May 15;142C(2):86-94. Review.
    6. Kölker S, Garbade SF, Greenberg CR, Leonard JV, Saudubray JM, Ribes A,Kalkanoglu HS, Lund AM, Merinero B, Wajner M, Troncoso M, Williams M, Walter JH, Campistol J, Martí-Herrero M, Caswill M, Burlina AB, Lagler F, Maier EM, Schwahn B, Tokatli A, Dursun A, Coskun T, Chalmers RA, Koeller DM, Zschocke J,Christensen E, Burgard P, Hoffmann GF. Natural history, outcome, and treatmentefficacy in children and adults with glutaryl-CoA dehydrogenase deficiency.Pediatr Res. 2006 Jun;59(6):840-7.
    7. Kölker S, Hoffmann GF, Schor DS, Feyh P, Wagner L, Jeffrey I, Pourfarzam M,Okun JG, Zschocke J, Baric I, Bain MD, Jakobs C, Chalmers RA. Glutaryl-CoAdehydrogenase deficiency: region-specific analysis of organic acids andacylcarnitines in post mortem brain predicts vulnerability of the putamen.Neuropediatrics. 2003 Jun;34(5):253-60.
    8. Tang NL, Hui J, Law LK, Lam YY, Chan KY, Yeung WL, Chan AY, Cheung KL, Fok TF.Recurrent and novel mutations of GCDH gene in Chinese glutaric acidemia type Ifamilies. Hum Mutat. 2000 Nov;16(5):446.
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