Non-Coding RNAs

Subjects: Molecular Biology View times: 542
Submitted by: Franck Vazquez


A Non-Coding RNA, abbreviated ncRNA, is a ribonucleic acid (RNA) molecule which is either not translated into a protein or can be translated into a protein but is biologically active in its RNA form.

Major ncRNA families include ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), PIWI-interacting RNAs (piRNAs), small interfering RNAs (siRNAs), microRNAs (miRNAs), or long non-coding RNAs (lncRNAs) like the prototypic examples XIST or HOTAIR .



Ref: Palazzo, A. F., & Lee, E. S. (2015). Non-coding RNA: what is functional and what is junk? Frontiers in Genetics6, 2. http://doi.org/10.3389/fgene.2015.00002

Historical Perspective on ncRNA discovery

 Read review on non--coding RNAs in Arabidospis [1]


ncRNA families


There  are many different non-coding RNA families classified according to their origin, genetics pathway and  modus operandi [2].


Biological Roles





  1. Franck Vazquez; Arabidopsis endogenous small RNAs: highways and byways. Trends in Plant Science 2006, 11, 460-468, 10.1016/j.tplants.2006.07.006.
  2. Non-Coding RNA . Wikipedia. Retrieved 2018-11-19

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