Table of Contents

    Topic review

    Lujan Syndrome

    View times: 6
    Submitted by: Camila Xu
    (This entry belongs to Entry Collection "MedlinePlus ")


    Lujan syndrome is a condition characterized by intellectual disability, behavioral problems, and certain physical features. It occurs almost exclusively in males.

    1. Introduction

    The intellectual disability associated with Lujan syndrome is usually mild to moderate. Behavioral problems can include hyperactivity, aggressiveness, extreme shyness, and excessive attention-seeking. Some affected individuals have features of autism or related developmental disorders affecting communication and social interaction. A few have been diagnosed with psychiatric problems such as delusions and hallucinations.

    Characteristic physical features of Lujan syndrome include a tall, thin body and an unusually large head (macrocephaly). Affected individuals also have a long, thin face with distinctive facial features such as a prominent top of the nose (high nasal root); a short space between the nose and the upper lip (philtrum); a narrow roof of the mouth (palate); crowded teeth; and a small chin (micrognathia). Almost all people with this condition have weak muscle tone (hypotonia).

    Additional signs and symptoms of Lujan syndrome can include abnormal speech, heart defects, and abnormalities of the genitourinary system. Many affected individuals have long fingers and toes with an unusually large range of joint movement (hyperextensibility). Seizures and abnormalities of the tissue that connects the left and right halves of the brain (corpus callosum) have also been reported in people with this condition.

    2. Frequency

    Lujan syndrome appears to be an uncommon condition, but its prevalence is unknown.

    3. Causes

    Lujan syndrome is caused by at least one mutation in the MED12 gene. This gene provides instructions for making a protein that helps regulate gene activity; it is involved in many aspects of early development. The MED12 gene mutation that causes Lujan syndrome changes a single protein building block (amino acid) in the MED12 protein. This genetic change alters the structure, and presumably the function, of the MED12 protein. However, it is unclear how the mutation affects development and leads to the cognitive and physical features of Lujan syndrome.

    4. Inheritance

    This condition is inherited in an X-linked recessive pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, males are affected by X-linked recessive disorders much more frequently than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

    5. Other Names for This Condition

    • LFS

    • Lujan-Fryns syndrome

    • X-linked intellectual deficit with marfanoid habitus

    • X-linked mental retardation with marfanoid habitus

    • XLMR with marfanoid features

    The entry is from


    1. Lerma-Carrillo I, Molina JD, Cuevas-Duran T, Julve-Correcher C,Espejo-Saavedra JM, Andrade-Rosa C, Lopez-Muñoz F. Psychopathology in theLujan-Fryns syndrome: report of two patients and review. Am J Med Genet A. 2006Dec 15;140(24):2807-11. Review.
    2. Lujan JE, Carlin ME, Lubs HA. A form of X-linked mental retardation withmarfanoid habitus. Am J Med Genet. 1984 Jan;17(1):311-22.
    3. Lyons MJ. MED12-Related Disorders. 2008 Jun 23 [updated 2016 Aug 11]. In: AdamMP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle;1993-2020. Available from
    4. Schwartz CE, Tarpey PS, Lubs HA, Verloes A, May MM, Risheg H, Friez MJ,Futreal PA, Edkins S, Teague J, Briault S, Skinner C, Bauer-Carlin A, SimensenRJ, Joseph SM, Jones JR, Gecz J, Stratton MR, Raymond FL, Stevenson RE. Theoriginal Lujan syndrome family has a novel missense mutation (p.N1007S) in theMED12 gene. J Med Genet. 2007 Jul;44(7):472-7.
    5. Van Buggenhout G, Fryns JP. Lujan-Fryns syndrome (mental retardation,X-linked, marfanoid habitus). Orphanet J Rare Dis. 2006 Jul 10;1:26. Review.
    1. Please check and comment entries here.