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    Topic review

    Gestational Diabetes

    Subjects: Genetics
    View times: 9
    Submitted by: Camila Xu
    (This entry belongs to Entry Collection "MedlinePlus ")

    Definition

    Gestational diabetes is a disorder characterized by abnormally high blood sugar levels during pregnancy.

    1. Introduction

    Gestational diabetes affected women do not have diabetes before they are pregnant, and most of these women go back to being nondiabetic soon after the baby is born. The disease has a 30 to 70 percent chance of recurring in subsequent pregnancies. Additionally, about half of women with gestational diabetes develop another form of diabetes, known as type 2 diabetes, within a few years after their pregnancy.

    Gestational diabetes is often discovered during the second trimester of pregnancy. Most affected women have no symptoms, and the disease is discovered through routine screening at their obstetrician's office. If untreated, gestational diabetes increases the risk of pregnancy-associated high blood pressure (called preeclampsia) and early (premature) delivery of the baby.

    Babies of mothers with gestational diabetes tend to be large (macrosomia), which can cause complications during birth. Infants whose mothers have gestational diabetes are also more likely to develop dangerously low blood sugar levels soon after birth. Later in life, these individuals have an increased risk of developing obesity, heart disease, and type 2 diabetes.

    2. Frequency

    In the United States, up to 14 percent of all pregnancies are affected by gestational diabetes. The prevalence of gestational diabetes has been increasing rapidly over the past few decades (a trend similar to the increase in obesity and type 2 diabetes).

    The risk of developing gestational diabetes varies by ethnic background. Women of Native American, Asian, Hispanic, or African American heritage are more likely to be diagnosed with the disease than are non-Hispanic white women.

    3. Causes

    The causes of gestational diabetes are complex. This condition results from a combination of genetic, health, and lifestyle factors, some of which have not been identified.

    A hormone called insulin is important in the development of gestational diabetes. Insulin, which is produced in the pancreas, controls how much glucose (a type of sugar) is passed from the blood into cells to be used as an energy source. Under normal conditions, when blood sugar levels are high (such as after a meal), the pancreas releases insulin to move the excess glucose into cells, which reduces the amount of glucose in the blood.

    As a normal part of pregnancy, women develop a reduced ability to respond to the effects of insulin, known as insulin resistance. This process ensures that there is enough glucose to provide energy for the growing fetus. As insulin resistance develops, more and more insulin is needed to keep blood sugar levels within the normal range. As a result, insulin-producing cells in the pancreas (called beta cells) make larger amounts of insulin. These cells are usually able to keep up with the body's demand for insulin, and so most pregnant women do not develop gestational diabetes. However, in some women, pancreatic beta cells are unable to increase production of insulin enough to keep blood sugar levels within the normal range. The result is a rise in blood sugar levels (hyperglycemia) that characterizes gestational diabetes.

    Common variations (polymorphisms) in several genes have been associated with the risk of developing gestational diabetes. Because they are common, these variations can be present in people with gestational diabetes and in those without. It is the combination of these changes that helps determine a woman's likelihood of developing the disease. Although little is known about the genetics of gestational diabetes, studies suggest that the genes associated with this form of diabetes overlap with those associated with type 2 diabetes. These genes are involved in the development or function of insulin-producing beta cells in the pancreas or play a role in insulin resistance.

    Genetic variations likely act in combination with health and lifestyle factors to influence a woman's overall risk of developing gestational diabetes. Risk factors include having a previous pregnancy affected by gestational diabetes, being older (particularly over age 35) during pregnancy, or having previously had a baby who was large (over 9 pounds) at birth. Other health conditions that predispose to the disease include overweight or obesity, a hormonal imbalance called polycystic ovary syndrome (PCOS), and prediabetes (higher-than-normal blood sugar levels that do not reach the cutoff for diabetes). Many of the risk factors for gestational diabetes are the same factors that increase the risk of developing type 2 diabetes.

    4. Inheritance

    Gestational diabetes is a complex disease without a clear pattern of inheritance. However, many affected individuals have at least one close family member, such as a parent or sibling, with this disease or another form of diabetes (most commonly type 2 diabetes).

    5. Other Names for This Condition

    • diabetes mellitus arising in pregnancy

    • diabetes mellitus, gestational

    • diabetes mellitus, pregnancy related

    • diabetes, pregnancy-induced

    • GDM

    • gestational diabetes mellitus

    The entry is from https://medlineplus.gov/genetics/condition/gestational-diabetes

    References

    1. Bajaj K, Gross SJ. The genetics of diabetic pregnancy. Best Pract Res ClinObstet Gynaecol. 2015 Jan;29(1):102-9. doi: 10.1016/j.bpobgyn.2014.08.008.
    2. Catalano PM. The impact of gestational diabetes and maternal obesity on themother and her offspring. J Dev Orig Health Dis. 2010 Aug;1(4):208-15. doi:10.1017/S2040174410000115.
    3. Chen P, Wang S, Ji J, Ge A, Chen C, Zhu Y, Xie N, Wang Y. Risk factors andmanagement of gestational diabetes. Cell Biochem Biophys. 2015 Mar;71(2):689-94. doi: 10.1007/s12013-014-0248-2. Review.
    4. Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD. Gestational diabetes mellitus and long-term consequences for mother andoffspring: a view from Denmark. Diabetologia. 2016 Jul;59(7):1396-1399. doi:10.1007/s00125-016-3985-5.
    5. Kwak SH, Kim SH, Cho YM, Go MJ, Cho YS, Choi SH, Moon MK, Jung HS, Shin HD,Kang HM, Cho NH, Lee IK, Kim SY, Han BG, Jang HC, Park KS. A genome-wideassociation study of gestational diabetes mellitus in Korean women. Diabetes.2012 Feb;61(2):531-41. doi: 10.2337/db11-1034.
    6. Lowe WL Jr, Scholtens DM, Sandler V, Hayes MG. Genetics of GestationalDiabetes Mellitus and Maternal Metabolism. Curr Diab Rep. 2016 Feb;16(2):15. doi:10.1007/s11892-015-0709-z. Review.
    7. Wu L, Cui L, Tam WH, Ma RC, Wang CC. Genetic variants associated withgestational diabetes mellitus: a meta-analysis and subgroup analysis. Sci Rep.2016 Jul 29;6:30539. doi: 10.1038/srep30539. Review.
    8. Zhang C, Bao W, Rong Y, Yang H, Bowers K, Yeung E, Kiely M. Genetic variantsand the risk of gestational diabetes mellitus: a systematic review. Hum ReprodUpdate. 2013 Jul-Aug;19(4):376-90. doi: 10.1093/humupd/dmt013.Review.
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