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Nedoszytko, B.; Sobalska-Kwapis, M.; Strapagiel, D.; Lange, M.; Górska, A.; Elberink, J.N.G.O.; Van Doormaal, J.; Słomka, M.; Kalinowski, L.; Gruchała-Niedoszytko, M.; et al. Mastocytosis. Encyclopedia. Available online: https://encyclopedia.pub/entry/1647 (accessed on 20 April 2024).
Nedoszytko B, Sobalska-Kwapis M, Strapagiel D, Lange M, Górska A, Elberink JNGO, et al. Mastocytosis. Encyclopedia. Available at: https://encyclopedia.pub/entry/1647. Accessed April 20, 2024.
Nedoszytko, Bogusław, Marta Sobalska-Kwapis, Dominik Strapagiel, Magdalena Lange, Aleksandra Górska, Joanne N. G. Oude Elberink, Jasper Van Doormaal, Marcin Słomka, Leszek Kalinowski, Marta Gruchała-Niedoszytko, et al. "Mastocytosis" Encyclopedia, https://encyclopedia.pub/entry/1647 (accessed April 20, 2024).
Nedoszytko, B., Sobalska-Kwapis, M., Strapagiel, D., Lange, M., Górska, A., Elberink, J.N.G.O., Van Doormaal, J., Słomka, M., Kalinowski, L., Gruchała-Niedoszytko, M., Nowicki, R.J., Valent, P., & Niedoszytko, M. (2020, August 14). Mastocytosis. In Encyclopedia. https://encyclopedia.pub/entry/1647
Nedoszytko, Bogusław, et al. "Mastocytosis." Encyclopedia. Web. 14 August, 2020.
Mastocytosis
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This entry is adapted from the peer-reviewed paper 10.3390/ijms21155506

Mastocytosis is a heterogeneous group of rare diseases defined by abnormal accumulation of clonal mast cells (MC) in the skin, bone marrow and/or other visceral organs.

Bibliography

1. Introduction

Mast cells (MC) are healthy, bone marrow derived  cells in the body, usually found in the skin and other tissues. MC are multifunctional cells regulating both innate and adaptative immune system. MC participate in detection of harmful pathogens like viruses, bacteria, parasites and toxins, play the role in wound healing, cancer and tumor progression. Inappropriate, recurrent  mast cell activation (MCA) and secretion MC-derived mediators plays an essential role in many human diseases:  allergy, asthma, allergic rhinitis, urticaria, anaphylaxis, atopic dermatitis, mastocytosis and mast cell activation syndrome (MCAS) [5].  MC have a role in the early steps of the body’s coordination of healing responses to an injury. [6][33][34]. MC granules within the mast cells contain histamine and other chemicals (figure 1) :

  • histamine
  • leukotriene C4
  • prostaglandin D2
  • carboxypeptidase
  • heparin
  • cathepsin G-like protease
  • tryptase
  • tumour necrosis factor-A
  • chymase
  • interleukin-3, 4, 6, 8
  • others

When a mast cell is activated, these chemicals are released into the surrounding skin. Mast cell chemicals are mediators of inflammation, and cause the blood vessels to leak, resulting in localised itching, swelling, redness and sometimes blistering. This reaction is normal in insect bites and is thought to be a protective mechanism. For example, a mosquito injects saliva when it bites. The saliva triggers mast cell activation to a varying degree, depending on the individual's hypersensitivity to the saliva. The unpleasant itch soon persuades the person to try to avoid getting bitten again.

Figure 1. Mast Cell and its triggering factors, their corresponding receptors (if those are present), activation pathways and degranulation products. (IgE – immunoglobulin E, IgG – immunoglobulin G, ACTH – Adrenocorticotropic hormone, CRH – corticotropin-releasing hormone, Rab3A – Ras-related protein, HR – histamine receptor, FcεRI – receptor for immunoglobulin E, FcγR – receptor for immunoglobulin G, CRHR – corticotropin-releasing hormone receptor, TLR – Toll like receptor, PR – progesterone receptor, ERα – estrogen receptor α, KIT – Tyrosine kinase receptor, IL-6R – receptor specific for interleukin 6, Lyn – Tyrosine-protein kinase, Syk – spleen tyrosine kinase, PLCγ1 – 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma 1, RAS – small GTPase class protein, ERK – extracellular signal-regulated kinase, JAK – Janus kinase, STAT – signal transducer and activator of transcription, IL-6 – interleukin 6, PAF – Platelet Activating Factor, TNF-α – Tumor necrosis factor α, IL-3 – Interleukin 3, IL-4 – Interleukin 4, PI3K, phosphatidylinositol 3-kinase, DAG, diacylglycerol,IP3, inositol 1,4,5-triphosphate).

2. Classification of mastocytosis

Mastocytosis can be divided in WHO classification into 7 variants: cutaneous mastocytosis (CM), indolent systemic mastocytosis (ISM), smoldering SM (SSM), SM with an associated hematological neoplasm (SM‐AHN), aggressive SM (ASM), MC leukemia (MCL), and MC sarcoma (MCS). The diagnosis of systemic mastocytosis (SM) is based on WHO criteria, including the basal serum tryptase level, histopathological and immunophenotypic (CD2/CD25) features of MCs and somatic KIT mutations in codon 816 [1].

The majority of children are suffering from CM and have a favorable prognosis with spontaneous regression in puberty period. In contrast, in adults, mastocytosis usually presents as SM, and sometimes progresses to an aggressive disease. The background of spontaneous regression of the disease in pubertal period observed in some children remains unclear [2][3][4][5][6][7][8].

In most patients with SM, somatic mutations in the KIT gene are found, the most prevalent in SM being D816V (rs121913507, D[GAC] > V [GTC]). The protein product of KIT (KIT=CD117) gene is a transmembrane receptor for stem cell factor (SCF), a major regulator of MC differentiation and survival. The KIT D816V mutation results in SCF‐independent differentiationof MCs. KIT D816V mutation is detected in more than 80% of all adults with SM. In contrast in children with CM, this mutation is less frequent (35%) and other mutations, located in gene regions encoding the external cellular domain of KIT ((Del419, F522C, ITD502–503, K509I, M541L, L852L), are more commonly found childhood patients (18%). Furthermore, it was found that 48% of children had the wild type WT sequence at codon 816 [7][9][10].

3. Diagnosis

3.1. Cutaneous mastocytosis

Cutaneous mastocytosis  (CM) is usually diagnosed by its clinical appearance and positive Darier sign. However, a skin biopsy may be helpful for confirmation of clinical diagnosis. [5][31][32].

There different  form of CM:

  • Solitary mastocytoma
  • Maculopapular cutaneous mastocytosis
  • Diffuse cutaneous mastocytosis
  • Telangiectatic cutaneous mastocytosis (telangiectasia macularis eruptiva perstans)
  • Plaque-type mastocytoma
  • Solitary and multiple nodular mastocytomas

3.2. Systemic mastocytosis

3.2.1. Major criteria

  • Multiple areas of dense infiltrate of mast cells in the bone marrow or other extracutaneous organs, confirmed by special stains on histology, such as mast cell tryptase (> 15 mast cell aggregating)

3.2.2. Minor criteria

  • In mast cell infiltrates in the bone marrow or other extracutaneous organs, >25% of mast cells are spindle-shaped or otherwise atypical OR in bone marrow smears > 25% of mast cells are spindle-shaped or otherwise atypical
  • Activating point mutation of the stem cell factor, c-KIT in codon 816 is present in extracutaneous organs using PCR-based technology
  • Mast cells in extracutaneous organs found using CD117 co-express either CD2 or CD25, or both, as determined by flow cytometry
  • Serum tryptase is persistently > 20ng/ml (this is not relevant in patients that have SM-AHNMD)

To set the diagnosis of systemic mastocytosis, ether one major + one minor criterium or 3 minor criteria has to be fulfilled [1][2][3][4].

Systemic mastocytosis occurs more commonly in adults than children (it is extremely rare in children).

3.3. Indolent systemic mastocytosis

Indolent systemic mastocytosis is the most common and least serious presentation of systemic mastocytosis in adults – it is characterised by a low mast cell burden (<30%), the presence of mediator-related symptoms such as flushing and diarrhoea, and skin involvement (usually maculopapular cutaneous mastocytosis, see above).

3.4. Genetic background of mastocytosis

Studies of genetic background performed so far in CM and SM focused on gene polymorphisms of cytokines and their receptors (IL-13, IL-6, IL6R, IL-31, IL4R, VEGFA), TLRs and variants of the KIT gene have shown that some cytokine or cytokine receptor gene polymorphisms may be associated with the presence of SM and/or CM [11][12][13][14][15][16]. Other studies performed in ISM found associations of SM disease with SNPs in RAB27A, ETS1, ITGB1, MLL3, and ITGAV genes [17].

In advanced SM, additional to D816V recurrent somatic mutations involving genes encoding factors regulating splicing, signaling transmission and epigenetic processes have recently been described [17][18][19][20][21]. The most frequently mutated genes are TET-2, DNMT3A, SRSF2, ASXL1, and RUNX. increase D816V oncogenic potential [18][19][20][21][22].

In general mastocytosis is not a genetic disease, a germline mutations of KIT gene in children with mastocytosis were rare, occurring in different gene regions  [15][16][17],  and is estimated in 4% (34/916)) of published cases and 9% of twins [26]. Many of these changes are polymorphic .  In familial cases is inherited in autosomal dominant mode of inheritance [26][27][28][31][32]. 

4. Clinical symptoms

When mast cells degranulate, the substances that are released can cause a number of symptoms that can vary over time and can range in intensity from mild to severe. Because mast cells play a role in allergic reactions, the symptoms of mastocytosis often are similar to the symptoms of an allergic reaction [1][2][3][4][5][6][31][32]. They may include (table 1):

5. Treatment

In a majority of patients with mastocytosis, mediator-induced symptoms are recorded. These symptoms may be mild, severe or even life-threatening, especially when a concomitant IgE-dependent allergy is also present

The treatment for mastocytosis depends on the particular symptoms of each person. Treatment for symptoms that affect the skin include antihistamines and oral psoralen plus UVA (PUVA) therapy. If the symptoms are not responsive to other treatment, a doctor may prescribe steroid creams, ointments, or solutions to be applied to the skin (topical corticosteroids treatment), imatinib, mast cells stabilisers ( Cromolyn sodium), kinase inhibitors (Midostaurin),  epinephrine, and/or IgE-targeting antibodies are required to bring anaphylaxis (MCAS events) under control.
Proton pump inhibitors can be used to treat gastrointestinal symptoms and bone pain. Many specialists recommended that people with mastocytosis have injectable epinephrine that they can use in case of anaphylactic shock. Other recommendations include trying to avoid known triggers of symptoms of mastocytosis [23][24][25][30].

Table 1

Clinical effects of mast cell mediators produced and released during MCA*              
Symptomatology of MCA        Relevant involved mediators**    
Vascular instability, hypotension,    Histamine, LTC4, LTE4, PGD2, VEGF,         
tachycardia, syncopy, anaphylaxis*     PAF, TNF-alpha        
Enhanced vasopermeability, edema   Histamine, VEGF, LTC4, LTE4, PAF        
formation in various organs            
Headache and nausea        Histamine    
             
Fever and chills***         TNF-alpha  
Urticaria, pruritus, flushing       Histamine, VEGF      
             
Bronchoconstriction       Histamine, PGD2, LTC4, LTD4, PAF    
Mucus secretion          Histamine, Proteases, PGD2, LTC4   
             
Nasal congestion, wheezing      Histamine      
             
Gastric hypersecretion       Histamine    
Abdominal pain and cramping       Histamine, LTC4, PAF       
Diarrhoea         Histamine

*Clinical symptoms recorded in patients with mastocytosis and MCAS. In patients with MCAS more than one symptom are typically recorded and in most patients, hypotension and signs of anaphylaxis are found. **Some of the clinically most relevant mast cell-derived mediators are listed. In patients with MCAS, histamine and arachidonic acid derivatives may play a central role. The impact of the other mast cell-derived mediators, like PAF, remains at present unknown. ***In about 1% of all patients with MCA, severe hypotension is associated with fever. Abbreviations: MCA, mast cell activation; MCAS, MCA syndrome; LT, leukotriene; PG, prostaglandin; VEGF, vascular endothelial growth factor (=vascular permeability factor), PAF, platelet activating factor.

6. Epidemiology

Mastocytosis is described as a rare disease, but to our knowledge, the exact incidence and prevalence are not known. A diseaseis considered rare if it affects fewer than 200,000 people in the United States at any given time. An estimate of prevalence from a recent population-based study is approximately 1 case per 10,000 people [6].

References

  1. Valent, P.; Horny, H.P.; Escribano, L.; Longley, B.J.; Li, C.Y.; Schwartz, L.B.; Marone, G.; Nunez, R.; Akin, C.; Sotlar, K., et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res 2001, 25, 603-625, doi:10.1016/s0145-2126(01)00038-8.
  2. Valent, P.; Akin, C.; Escribano, L.; Fodinger, M.; Hartmann, K.; Brockow, K.; Castells, M.; Sperr, W.R.; Kluin-Nelemans, H.C.; Hamdy, N.A., et al. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest 2007, 37, 435-453, doi:10.1111/j.1365-2362.2007.01807.x.
  3. Valent, P.; Akin, C.; Hartmann, K.; Nilsson, G.; Reiter, A.; Hermine, O.; Sotlar, K.; Sperr, W.R.; Escribano, L.; George, T.I., et al. Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future. Cancer Res 2017, 77, 1261-1270, doi:10.1158/0008-5472.CAN-16-2234.
  4. Valent, P.; Akin, C.; Metcalfe, D.D. Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts. Blood 2017, 129, 1420-1427, doi:10.1182/blood-2016-09-731893.
  5. Hartmann, K.; Escribano, L.; Grattan, C.; Brockow, K.; Carter, M.C.; Alvarez-Twose, I.; Matito, A.; Broesby-Olsen, S.; Siebenhaar, F.; Lange, M., et al. Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol 2016, 137, 35-45, doi:10.1016/j.jaci.2015.08.034.
  6. Theoharides, T.C.; Valent, P.; Akin, C. Mast Cells, Mastocytosis, and Related Disorders. N Engl J Med 2015, 373, 1885-1886, doi:10.1056/NEJMc1510021.
  7. Arock, M.; Sotlar, K.; Akin, C.; Broesby-Olsen, S.; Hoermann, G.; Escribano, L.; Kristensen, T.K.; Kluin-Nelemans, H.C.; Hermine, O.; Dubreuil, P., et al. KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. Leukemia 2015, 29, 1223-1232, doi:10.1038/leu.2015.24.
  8. Lange, M.; Lugowska-Umer, H.; Niedoszytko, M.; Wasag, B.; Limon, J.; Zawrocki, A.; Nedoszytko, B.; Sobjanek, M.; Plata-Nazar, K.; Nowicki, R. Diagnosis of Mastocytosis in Children and Adults in Daily Clinical Practice. Acta Derm Venereol 2016, 96, 292-297, doi:10.2340/00015555-2210.
  9. Bibi, S.; Langenfeld, F.; Jeanningros, S.; Brenet, F.; Soucie, E.; Hermine, O.; Damaj, G.; Dubreuil, P.; Arock, M. Molecular defects in mastocytosis: KIT and beyond KIT. Immunol Allergy Clin North Am 2014, 34, 239-262, doi:10.1016/j.iac.2014.01.009.
  10. Soucie, E.; Brenet, F.; Dubreuil, P. Molecular basis of mast cell disease. Mol Immunol 2015, 63, 55-60, doi:10.1016/j.molimm.2014.03.013.
  11. Daley, T.; Metcalfe, D.D.; Akin, C. Association of the Q576R polymorphism in the interleukin-4 receptor alpha chain with indolent mastocytosis limited to the skin. Blood 2001, 98, 880-882, doi:10.1182/blood.v98.3.880.
  12. Nedoszytko, B.; Niedoszytko, M.; Lange, M.; van Doormaal, J.; Glen, J.; Zablotna, M.; Renke, J.; Vales, A.; Buljubasic, F.; Jassem, E., et al. Interleukin-13 promoter gene polymorphism -1112C/T is associated with the systemic form of mastocytosis. Allergy 2009, 64, 287-294, doi:10.1111/j.1398-9995.2008.01827.x.
  13. Rausz, E.; Szilagyi, A.; Nedoszytko, B.; Lange, M.; Niedoszytko, M.; Lautner-Csorba, O.; Falus, A.; Aladzsity, I.; Kokai, M.; Valent, P., et al. Comparative analysis of IL6 and IL6 receptor gene polymorphisms in mastocytosis. Br J Haematol 2013, 160, 216-219, doi:10.1111/bjh.12086.
  14. Nedoszytko, B.; Lange, M.; Renke, J.; Niedoszytko, M.; Zablotna, M.; Glen, J.; Nowicki, R. The Possible Role of Gene Variant Coding Nonfunctional Toll-Like Receptor 2 in the Pathogenesis of Mastocytosis. Int Arch Allergy Immunol 2018, 177, 80-86, doi:10.1159/000489343.
  15. Lange, M.; Glen, J.; Zablotna, M.; Nedoszytko, B.; Sokolowska-Wojdylo, M.; Rebala, K.; Lugowska-Umer, H.; Niedoszytko, M.; Gorska, A.; Sikorska, M., et al. Interleukin-31 Polymorphisms and Serum IL-31 Level in Patients with Mastocytosis: Correlation with Clinical Presen-tation and Pruritus. Acta Derm Venereol 2017, 97, 47-53, doi:10.2340/00015555-2474.
  16. Orfao, A.; Garcia-Montero, A.C.; Sanchez, L.; Escribano, L.; Rema. Recent advances in the understanding of mastocytosis: the role of KIT mutations. Br J Haematol 2007, 138, 12-30, doi:10.1111/j.1365-2141.2007.06619.x.
  17. Niedoszytko, M.; Oude Elberink, J.N.; Bruinenberg, M.; Nedoszytko, B.; de Monchy, J.G.; te Meerman, G.J.; Weersma, R.K.; Mulder, A.B.; Jassem, E.; van Doormaal, J.J. Gene expression profile, pathways, and transcriptional system regulation in indolent systemic mastocytosis. Allergy 2011, 66, 229-237, doi:10.1111/j.1398-9995.2010.02477.x.
  18. Traina, F.; Visconte, V.; Jankowska, A.M.; Makishima, H.; O'Keefe, C.L.; Elson, P.; Han, Y.; Hsieh, F.H.; Sekeres, M.A.; Mali, R.S., et al. Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis. PLoS One 2012, 7, e43090, doi:10.1371/journal.pone.0043090.
  19. Schwaab, J.; Schnittger, S.; Sotlar, K.; Walz, C.; Fabarius, A.; Pfirrmann, M.; Kohlmann, A.; Grossmann, V.; Meggendorfer, M.; Horny, H.P., et al. Comprehensive mutational profiling in advanced systemic mastocytosis. Blood 2013, 122, 2460-2466, doi:10.1182/blood-2013-04-496448.
  20. Damaj, G.; Joris, M.; Chandesris, O.; Hanssens, K.; Soucie, E.; Canioni, D.; Kolb, B.; Durieu, I.; Gyan, E.; Livideanu, C., et al. ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. PLoS One 2014, 9, e85362, doi:10.1371/journal.pone.0085362.
  21. Jawhar, M.; Schwaab, J.; Schnittger, S.; Sotlar, K.; Horny, H.P.; Metzgeroth, G.; Muller, N.; Schneider, S.; Naumann, N.; Walz, C., et al. Molecular profiling of myeloid progenitor cells in multi-mutated advanced systemic mastocytosis identifies KIT D816V as a distinct and late event. Leukemia 2015, 29, 1115-1122, doi:10.1038/leu.2015.4.
  22. Jawhar, M.; Schwaab, J.; Schnittger, S.; Meggendorfer, M.; Pfirrmann, M.; Sotlar, K.; Horny, H.P.; Metzgeroth, G.; Kluger, S.; Naumann, N., et al. Additional mutations in SRSF2, ASXL1 and/or RUNX1 identify a high-risk group of patients with KIT D816V(+) advanced systemic mastocytosis. Leukemia 2016, 30, 136-143, doi:10.1038/leu.2015.284.
  23. Alvarez-Twose, I.; Matito, A.; Morgado, J.M.; Sanchez-Munoz, L.; Jara-Acevedo, M.; Garcia-Montero, A.; Mayado, A.; Caldas, C.; Teodosio, C.; Munoz-Gonzalez, J.I., et al. Imatinib in systemic mastocytosis: a phase IV clinical trial in patients lacking exon 17 KIT mutations and review of the literature. Oncotarget 2017, 8, 68950-68963, doi:10.18632/oncotarget.10711.
  24. Ustun, C.; DeRemer, D.L.; Akin, C. Tyrosine kinase inhibitors in the treatment of systemic mastocytosis. Leuk Res 2011, 35, 1143-1152, doi:10.1016/j.leukres.2011.05.006.
  25. Valent, P.; Akin, C.; Sperr, W.R.; Mayerhofer, M.; Fodinger, M.; Fritsche-Polanz, R.; Sotlar, K.; Escribano, L.; Arock, M.; Horny, H.P., et al. Mastocytosis: pathology, genetics, and current options for therapy. Leuk Lymphoma 2005, 46, 35-48, doi:10.1080/10428190400010775.
  26. C Méni , J Bruneau, S Georgin-Lavialle, L Le Saché de Peufeilhoux, G Damaj, S Hadj-Rabia, S Fraitag, P Dubreuil, O Hermine, C Bodemer (2015): Paediatric mastocytosis: a systematic review of 1747 cases. Br J Dermatol 172:642-651.
  27. Zang LY, Smith ML, Schultheis B et al. (2006): A novel K509I mutations of KIT identified in familial mastocytosis - in utero and in vivo responsiveness to imatinib therapy. Leuk Res 30:373-378.
  28. Wasąg B, Niedoszytko M, Piskorz A et al. (2011): Novel, activating KIT-N822I mutation in familial cutaneous mastocytosis. Exp Hematol 39:859-865.
  29. Moura, Daniela Silva; Sultan, Serge; Georgin-Lavialle, Sophie; Pillet, Nathalie; Montestruc, François; Gineste, Paul; Barete, Stéphane; Damaj, Gandhi; Moussy, Alain; Lortholary, Olivier; Hermine, Olivier; Hashimoto, Kenji (21 October 2011). "Depression in Patients with Mastocytosis: Prevalence, Features and Effects of Masitinib Therapy". PLOS ONE. 6 (10): e26375.
  30. Valent P, Akin C, Gleixner KV, et al. Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches. Int J Mol Sci. 2019;20(12):2976. Published 2019 Jun 18. doi:10.3390/ijms20122976.
  31. Lange M, Ługowska-Umer H, Niedoszytko M, et al. Diagnosis of Mastocytosis in Children and Adults in Daily Clinical Practice. Acta Derm Venereol. 2016;96(3):292-297. doi:10.2340/00015555-2210
  32. Lange M, Nedoszytko B, Górska A, Zawrocki A, Sobjanek M, Kozlowski D. Mastocytosis in children and adults: clinical disease heterogeneity. Arch Med Sci. 2012;8(3):533-541. doi:10.5114/aoms.2012.29409
  33. Renke J, Kędzierska-Mieszkowska S, Lange M, et al. Mast cells in mastocytosis and allergy - Important player in metabolic and immunological homeostasis. Adv Med Sci. 2019;64(1):124-130. doi:10.1016/j.advms.2018.08.013
  34. Romantowski J, Górska A, Lange M, Nedoszytko B, Gruchała-Niedoszytko M, Niedoszytko M. How to diagnose mast cell activation syndrome: practical considerations. Pol Arch Intern Med. 2020;130(4):317-323. doi:10.20452/pamw.15212
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Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Bogusław Nedoszytko
,
Marta Sobalska-Kwapis
,
Dominik Strapagiel
,
Magdalena Lange
,
Aleksandra Górska
,
Joanne N. G. Oude Elberink
,
Jasper van Doormaal
,
Marcin Słomka
,
Leszek Kalinowski
,
Marta Gruchała-Niedoszytko
,
Roman J. Nowicki
,
Peter Valent
,
Marek Niedoszytko
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