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Weaning is the most crucial event in commercial pig farms in terms of animal productivity and health. The newly weaned pig not only transits from milk to a solid and more complex diet, but is also subjected to additional stressors including separation from sow and littermates, co-mingling with unknown pigs, adaptation to new environmental settings, and increased pathogen exposure. All these stressors result in reduced feed intake, lasting up to 48 h post-weaning, which is the main driver of the observed gastrointestinal dysfunction, poor performance, and post-weaning diarrhoea (PWD). Marine polysaccharides from macroalgae and chitin provide an interesting source of novel bio-actives and are interesting group of natural dietary supplements for use in pig nutrition due to their prebiotic, antibacterial, and immunomodulatory activities. Hence, they offer great potential as preventatives and prophylactics in pig diets.
Pig Age | Dietary Supplement | Dose | Time and Duration of Supplementation | Effect on Growth Performance and Diarrhoea Scores | Effect on Parameters of GIT Functionality and Health | Ref. |
---|---|---|---|---|---|---|
Weaned pigs | ||||||
24-day-old | Laminarin (Laminaria spp.) Fucoidan (Laminaria spp.) Laminarin + Fucoidan |
300 mg/kg 240 mg/kg 300 mg/kg + 240 mg/kg |
After weaning for 21 days | + ADG and G:F in pigs fed laminarin-supplemented diets + ADG in pigs fed with diet supplemented solely with fucoidan (interaction) − diarrhoea score in pigs fed laminarin-supplemented diets |
− faecal E. coli in pigs fed laminarin-supplemented diets + faecal Lactobacillus spp. in pigs fed with diet supplemented solely with fucoidan (interaction) |
[42] |
24-day-old | Laminarin (Laminaria spp.) Fucoidan (Laminaria spp.) Laminarin + Fucoidan |
150 or 300 mg/kg 240 mg/kg 150 or 300 mg/kg + 240 mg/kg |
After weaning for 35 days | + ADG in pigs fed 300 mg/kg laminarin-supplemented diets + G:F in pigs fed with diet supplemented solely with 300 mg/kg laminarin or fucoidan (interaction) − FS in pigs fed 150 or 300 mg/kg laminarin-supplemented diets and in pigs fed with diet supplemented solely with fucoidan (interaction) |
+ faecal Lactobacillus spp. in pigs fed fucoidan-supplemented diets 0 faecal E. coli, Bifidobacterium spp. |
[43] |
28-day-old | 65% laminarin-rich extract (Laminaria spp.) | 300 mg/kg | After weaning for 14 days | + ADG, ADFI 0 diarrhoea score |
+ VH in duodenum and jejunum and CD in jejunum − Enterobacteriaceae in caecum + Lactobacillus spp. in colon + butyrate in colon + gene expression of nutrient transporters in small intestine and colon − gene expression of tight junction proteins, mucins and immune markers in small intestine and colon |
[44] |
35-day-old | Dried seaweed (Ocean Harvest Technology) containing laminarin, fucoidan, alginate, mannitol, fucoxanthin and rhamnose sulphate. | 1500 mg/kg | After weaning for 52 days | 0 ADG, ADFI, G:F 0 diarrhoea score |
− VH in jejunum | [46] |
35-day-old | Dried sea weed (Ascophyllum nodosum) | 2.5 g/kg 5 g/kg 10 g/kg |
After weaning for 28 days | − ADG | ND | [48] |
Finisher pigs | Dried seaweed extract (Ascophyllum nodosum) containing laminarin, fucoidan, alginate, mannitol, fucoxanthin and rhamnose sulphate. | 3 g/kg 6 g/kg 9 g/kg |
After weaning for 28 days | − ADG 0 ADFI, G:F |
ND | [49] |
28-day-old | 65% laminarin-rich extract (Laminaria spp.) | 300 mg/kg | After weaning for 14 days | + ADG, ADFI 0 diarrhoea score |
− abundance of OTUs assigned to Enterobacteriaceae + abundance of OTUs assigned to the genus Prevotella |
[57] |
24-day-old | Laminarin (Laminaria spp.) Fucoidan (Laminaria spp.) Laminarin + Fucoidan |
300 mg/kg 240 mg/kg 300 mg/kg + 240 mg/kg |
After weaning for 8 days | ND | − Enterobacteriaceae population in pigs offer fucoidan (interaction). − AEEC strains in pigs offer laminarin (interaction). + VH and VH:CD ratio in pigs offered laminarin or fucoidan (interaction). − IL-6, IL-17A and IL-1b mRNA expression in pigs offered laminarin |
[58] |
24-day-old | Laminarin (Laminaria spp.) | After weaning for 8 days | + ADG and ADFI − diarrhoea score |
ND | [59] | |
24-day-old | Laminarin (Laminaria spp.) |
0 mg/kg 240 mg/kg ZnO |
After weaning for 32 days | + ADG and G:F, similar effect to ZnO | + digestibility of GE + the expression of glucose transporters in small intestine compared with the basal diet. |
[60] |
24-day-old | 44% fucoidan-rich extract (Laminaria spp.) | 0 mg/kg 125 mg/kg 250 mg/kg |
After weaning for 14 days | − diarrhoea score 0 ADG, ADFI and G:F |
0 effect on VH − abundance of Prevotella and Lachnospiraceae + the abundance of Helicobacter |
[61] |