1. Background

Hidradenitis suppurativa (HS) can be complicated by cutaneous squamous cell carcinoma (cSCC).

2. Objectives

This Individual Patient Data (IPD) meta-analysis was per-formed to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome.

3. Methods

Medline/PubMed, Embase and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing and Kaplan-Meier survival curves/Cox proportional hazards regression models were performed.

4. Results

34 case reports and series including 138 patients were identified. The majority of patients were men (81.6%), Caucasian (83.3%) and smokers (n=22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage III HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.6 years. HPV was identified in 12/38 patients. 45.7% of individuals had nodal metastasis and 31.3% had distant metastases. 51.8% of patients succumbed to their disease.

5. Conclusions

cSCC is one of the most life-threatening complications seen in HS patients. This cancer is more likely to occur in Caucasian smoker men with severe, longstanding gluteal HS. Regu-lar clinical examination and biopsy of any suspicious lesions in high-risk patients as well as HPV vaccination should be considered.

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