Nanotubes drug carrier
Nanotubes drug carrier with length about 50 to 850 nm is designed for drug delivery system. It can achieve some aims such as increasing drug solubility, improving drug bioavailability, and targeting therapies. Through nanotubes drug carrier, controlling the release of drug is able to achieved, which benefits to keep effective drug concentration, extend efficacy, and reduce dosing frequency. Halloysite nanotubes (HNTs) are natural occurring mineral clay nanotubes with excellent potential in different fields, especially further modified. For example, the chlorhexidine gluconate was loaded into HNTs, and In vitro drug release assay showed the drug could be released in a sustainable manner and can last about 10 days. HNTs-composited thermo or pH-responsive hydrogel system has been successfully developed for controlled drug release. The former reaction mechanism is the copolymerization of N-isopropylacrylamide with silane-modified HNTs through thermally initiated free-radical polymerization. The latter is the cross-linking degree change of alginate with silane-modified HNTs by gastrointestinal tract environment pH induced ions exchange reaction.
- Yang, Y.; Chen, Y.; Leng, F.; Huang, L.; Wang, Z.; Tian, W., Recent advances on surface modification of halloysite nanotubes for multifunctional applications. Applied Sciences, 2017, 7 (12), 1215, 10.3390/app7121215.
- Wu, Y.; Yang, Y.; Liu, H.; Yao, X.; Leng, F.; Chen, Y.; Tian, W., Long-term antibacterial protected cotton fabric coating by controlled release of chlorhexidine gluconate from halloysite nanotubes. Rsc Advances, 2017, 7 (31), 18917-18925, 10.1039/c7ra01464c.
- Haoyang Liu , Zhi-Gang Wang , Shu-Lin Liu, Xihui Yao , Yun Chen , Shirley Shen , Yu Wu , and Weiqun Tian*, Intracellular pathway of halloysite nanotubes: potential application for antitumor drug delivery, Journal of Materials Science, 2018, https://doi.org/10.1007/s10853-018-2775-5