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Hua, R. Isoquinolone. Encyclopedia. Available online: https://encyclopedia.pub/entry/11895 (accessed on 18 April 2024).
Hua R. Isoquinolone. Encyclopedia. Available at: https://encyclopedia.pub/entry/11895. Accessed April 18, 2024.
Hua, Ruimao. "Isoquinolone" Encyclopedia, https://encyclopedia.pub/entry/11895 (accessed April 18, 2024).
Hua, R. (2021, July 09). Isoquinolone. In Encyclopedia. https://encyclopedia.pub/entry/11895
Hua, Ruimao. "Isoquinolone." Encyclopedia. Web. 09 July, 2021.
Isoquinolone
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This entry is adapted from the peer-reviewed paper 10.3390/catal11050620

Isoquinolones (isoquinolin-1(2H)-ones): the atom- and step-economic syntheses.

alkyne annulation isoquinolone

1. Introduction

Annulation protocols with unsaturated hydrocarbons are important and efficient methods for syntheses of cyclic compounds with high atom-utilization and step-economy, which have been extensively investigated in synthetic chemistry [1][2][3][4][5][6][7][8][9][10]. Isoquinolones are not only interesting and important nitrogen-heterocyclic compounds showing versatile biological and physiological activities but also useful synthetic blocks [11][12][13][14]. Several efficient approaches are available for the syntheses of isoquinolones, and the reported early works include the reactions of pyrroline-2,3-diones with benzyne [15], using dilithiated N-propenyl-ortho-toluamides [16], dilithiated 2-methyl-N-aryl-benzamides [17] as intermediates, and multi-step including SNAr reaction [18].
Over the past decades, isoquinolone ring construction through inter-/intramolecular annulation protocols of unsaturated hydrocarbons with nitrogen-containing reaction partners have been rapidly developed by the activation of aryl C–H and aryl C–X (X = halogen) bonds, as well as N–H or N–O bonds. This short review provides an overview of the recent advances on this theme.

2. Isoquinolone Formation via [4 + 2] Intermolecular Annulations and Analogous Reactions

The cyclocondensation of benzamide derivatives and functionalized arenes with alkynes or C2 synthons have been recently made great progress for the efficient access to isoquinolones via a [4 + 2] annulation manner. The computational studies on the transition-metal-catalyzed aryl C–H oxidative cyclocondensation of benzamides with alkynes affording isoquinolones have also been reported [19].

2.1. [4 + 2]. Intermolecular Annulations via Aryl C–X/N–H Activation

The [4 + 2] intermolecular annulations of ortho-halobenzamides with alkynes via activation of aryl C–X (X = halogen)/N–H bond affording N-substituted isoquinolones have been extensively studied in the presence of nickel complexes under different conditions (Scheme 1). The general proposed mechanism includes the oxidative addition of orhto-halobenzamide to nickel (0) generated in situ in the presence of base leading to the formation of nickelacycle, coordinative insertion of alkyne into the nickelacycle giving possible two seven-membered ring nickelacycle intermediates, followed by reductive elimination affording isoquinolinone [20].
Catalysts 11 00620 sch001 550
Scheme 1. Isoquinolone formation by [4 + 2] intermolecular annulation of ortho-halobenzamides with alkynes via C–X/N–H activation.
With the use of air-stable [Ni(dppe)Br2] as catalyst, in the presence of Zn and Et3N, the reactions of ortho-halobenzamide with internal alkynes afford N-substituted isoquinolone derivatives (R’ = alkyl, allyl, benzyl, aryl) in good to high yields [20]. In the cases of unsymmetric internal alkynes and terminal alkynes used, the cyclocondensation shows regioselective manner, and the catalytic procedure can be used for the synthesis of isoquinolinone alkaloid natural products.
Ni(dppp)Cl2 can also catalyze the annulation of ortho-iodobenzamides with alkynes in the presence of Et3N in MeCN by selective cleavage of C–I/N–H bond [21]. Very recently, Ni(cod)2/KOtBu-catalyzed formation of highly substituted isoquinolones through cyclocondensation of ortho-fluorobenzamides with internal alkynes via C–F/N–H activation has also been reported [22].
With the use of ortho-haloarylamidines as substrates, in the presence of H2O and zinc, Ni(dppp)Cl2-catalyzed annulations with terminal and internal alkynes affords N-aryl isoquinolones in good to high yields (Scheme 2) [23].
Catalysts 11 00620 sch002 550
Scheme 2. Nickel-catalyzed annulation of ortho-haloarylamidines with alkynes affording N-aryl isoquinolones.
β-Keto esters are used as a C2 synthon in the formation of isoquinolones via [4 + 2] cyclocondensation with ortho-halobenzamides [24]. As shown in Scheme 3, CuI-catalyzed reactions of ortho-chloro, -bromo-, and -iodobenzamides or ortho-chloronicotinamide with β-keto esters in the presence of Cs2CO3 without addition of any ligand or additive afford 3,4-disubstituted N–H isoquinolone derivatives in moderate to high yields.
Catalysts 11 00620 sch003 550
Scheme 3. CuI-catalyzed synthesis of 3,4-disubstituted isoquinolones.
In addition, as shown in Scheme 4, in the presence of Pd(OAc)2 and PtBu3HBF4, norbornadiene can also be used as an acetylene equivalent in the synthesis of 3,4-unsubstituted N-benzyl isoquinolones via the annulation with ortho-chlorobenzamides [25]. A Cu(OAc)2.H2O-catalyzed cyclocoupling reaction of N-substituted ortho-iodo-benzamides with malononitrile afforded N-substituted-3-amino-4-cyano-isoquinolones in good to high yields, and malononitrile is used as C2 synthon [26].
Catalysts 11 00620 sch004 550
Scheme 4. Isoquinolone formation by cyclocoupling reactions of ortho-halobenzamides with norbornadiene or malononitrile.
The formation of functionalized isoquinolones by copper-catalyzed cyclocondensation of ketones with ortho-halobenzamides [27] or ortho-halobenzonitriles [28] through SNAr reaction giving α-aryl ketones as the intermediates have also been reported (Scheme 5).
Catalysts 11 00620 sch005 550
Scheme 5. Copper-catalyzed isoquinolone formation including SNAr reaction.

2.2. [4 + 2]. Intermolecular Annulations via Aryl C–H/N–O Activation Access to N–H Isoquinolones

Transition-metal-catalyzed annulations of alkynes with N-alkoxybenzamides by C–H/N–O bond cleavages with dealkoxylation reaction have been extensively investigated for the formation of N–H isoquinolones (Scheme 6).
Catalysts 11 00620 sch006 550
Scheme 6. Isoquinolone formation by [4 + 2] intermolecular annulation of N-alkoxybenzamides with alkynes via C–H/N–O activation.
Guimond and coworkers first studied the cyclocondensation of N-alkoxybenzamides with internal alkynes catalyzed by [Cp*RhCl2]2/CsOAc in methanol to synthesize N–H isoquinolones via C–H/N–O bond activation in 2010, and the mechanism was also investigated in detail [29][30]. The group CONH(OMe) is used as an oxidizing directing group, and the transformation occurs under external oxidant-free conditions.
The same catalyst system was then applied in the intramolecular reaction of alkyne-tethered N-alkoxybenzamides leading to a general and facile synthesis of 3-hydroxyalkyl-substituted N–H isoquinolones as the major products, and one of them can be used in the synthesis of natural product of Rosettacin, which is a polycyclic-fused isoquinolone derivative (Scheme 7) [31].
Catalysts 11 00620 sch007 550
Scheme 7. Synthesis of Rosettacin.
Similar conditions were then applied by other groups in the [4 + 2] cyclocondensation of N-pivaloyloxy benzamides with vinyl acetate [32], cyclopropenes [33], and substituted allenes [34] to develop the synthesis of 3,4-unsubstituted N–H isoquinolones and 3- or/and 4-substituted N–H isoquinolones (Scheme 8). In the case of the vinyl acetate used, it emerges as the convenient acetylene equivalent.
Catalysts 11 00620 sch008 550
Scheme 8. Rh(III)-catalyzed C–H/N–O activation/annulation of N-OPiv benzamides with vinyl esters, cyclopropenes, and allenes affording N–H isoquinolones.
In addition, 3,4-unsubstituted N–H isoquinolones can also be synthesized by annulation of benzoic acid with N-vinyl formamide catalyzed by [Cp*RhCl2]2 in the presence of AgOAc and KHCO3 in benzonitrile at 80 °C [35].
Thereafter, catalysis of [Cp*RhCl2]2/Bu4NOAc in DCE [36], [RuCl2(p-cymene)]2/NaOAc in MeOH [37][38], [RuCl2(p-cymene)]2/KO2CMes in water [39], [RuCl2(p-cymene)]2/KO2CMes/Cu(OAc)2.H2O in CHCl3 [40], [Os(p-cymene)Cl2]2/NaOAc/HOAc in trifluoroethanol (TFE) [41], and Co(OAc)2.4H2O/AgOAc/PivOH in TFE [42] have been developed to synthesize N–H isoquinolones from the reactions of secondary N-alkoxybenzamides with internal alkynes via selective N–O bond cleavage. The use of free hydroxamic acids is also successful to give the corresponding isoquinolones [39].
In addition, [RuCl2(p-cymene)]2/NaOAc in MeOH can be applied in the reactions of N-methoxybenzamide with alkynyl bromides affording 3-methoxy-4-substituted N–H isoquinolinones with excellent chemoselectivity via C–H/N–O activation [43]. Recently, the same catalyst system has been applied in the intramolecular cyclo-isomerization of alkyne-tethered N-alkoxybenzamides to give 3,4-disubstituted N–H isoquinolones (Scheme 9) [44]. The experimental and theoretical studies indicate that the reaction to the inverse annulation follows the Ru(II)-Ru(IV)-Ru(II) pathway involving N–O bond cleavage prior to alkyne insertion.
Catalysts 11 00620 sch009 550
Scheme 9. Ruthenium-catalyzed cascade C–H activation/annulation of alkyne-tethered N-alkoxybenzamides.
Moreover, the functionalized arenes have also been used as the coupling partners in the [4 + 2] annulations with alkynes to construct isoquinolone ring via activation of aryl C–H and N–E (E = N, C, O, Cl, etc.) bonds. As shown in Scheme 10, with the use of [Cp*RhCl2]2 as catalyst, the annulations of alkynes with benzoyl hydrazines (Scheme 10 (a)) [45], with 1,4,2-dioxazol-5-ones occur at room temperature (Scheme 10 (b)) [46], with N-iminopyridinium ylides (Scheme 10 (c)) [47]. However, with the use of AgNTf2 as co-catalyst, the reactions of 2-aryloxazolines with alkynes afford N-substituted isoquinolones (Scheme 10 (d)) [48].
Catalysts 11 00620 sch010 550
Scheme 10. Isoquinolone formation by rhodium (III)-catalyzed annulation of alkynes with different aryl substrates.
In the presence of KOAc, [Cp*Co(CO)I2]/AgOAc-catalyzed [4 + 2] annulation of N-chlorobenzamides with alkynes in TFE occurs at room temperature with selective cleavage of C–H/N–Cl bonds (Scheme 11) [49]. In the case of the use of terminal alkyne, the reactions occur with high regioselectivity to give 3-substituted N–H isoquinolones.
Catalysts 11 00620 sch011 550
Scheme 11. N–H isoquinolone formation by cobalt-catalyzed cyclocondensation of N-chloroamides with alkynes.

2.3. [4 + 2]. Intermolecular Annulations via Aryl C–H/N–H Activation

More atom-economical procedures for the formation of isoquinolones is the oxidative [4 + 2] cyclocondensation of primary and secondary benzamides with internal alkynes with selective cleavages of C–H and N–H bonds (Scheme 12).
Catalysts 11 00620 sch012 550
Scheme 12. Isoquinolone formation by [4 + 2] intermolecular annulation of benzamides with alkynes via C–H/N–H activation.
Miura and Satoh’s group reported the oxidative coupling of primary, secondary, and tertiary benzamides with internal alkynes catalyzed by rhodium complexes and with the use of Cu(OAc)2.2H2O as oxidant in 2010 [50]. As shown in Scheme 13, the reaction between primary benzamides with internal alkynes affords isoquinoline-fused polycyclic aromatics resulting from two incorporated molecules of alkynes. In the case of secondary benzamides, N-substituted isoquinolones are formed. Interestingly, the reaction of tertiary benzamides with internal alkynes under similar conditions produces 1-naphthalenecarboxamides through double aryl C–H bond activation (Scheme 14).
Catalysts 11 00620 sch013 550
Scheme 13. Rhodium-catalyzed cyclocondensation of primary/secondary benzamides with internal alkynes affording isoquinolones and fused isoquinolone.
Catalysts 11 00620 sch014 550
Scheme 14. Rhodium-catalyzed oxidative coupling of tertiary benzamides with internal alkynes.
In the same year, two similar works were also reported using [Cp*RhCl2]2 as catalyst to synthesize N-substituted isoquinolones by oxidative/cyclization of benzamides with internal alkynes via selective aryl C–H/N–H bonds cleavage [51][52]. Other rhodium catalysis of [Cp*Rh(MeCN)3]BF4/K2CO3 in water under air was then developed [53].
Although [RuCl2(p-cymene)]2-catalyzed annulations of N-alkoxybenzamides (R’ = alkoxy) with internal alkynes occur with dealkoxylation reactions via activation of N–O bond to give N–H isoquinolones [37][38][39][40], with the use of Cu(OAc)2·H2O as the terminal oxidant and t-AmOH as the solvent, the oxidative annulation of N-alkyl/arylbenzamides (R’ = alkyl, aryl) with internal alkynes gives efficient access to N-alkyl/aryl-substituted isoquinolones by highly selective cleavage of N–H bond [54][55].
In addition, when Pd(OAc)2 was used as a catalyst, in the presence of NaI.2H2O as additive, the methoxy substituent on nitrogen (R’ = alkoxy) was not cleaved during the catalysis under air, and the formation of N-methoxy isoquinolones had high chemoselectivity (Scheme 15) [56][57]. Under similar reaction conditions, using Cu(II) salts as the co-oxidants, a broad range of N-alkyl and N-aryl-substituted isoquinolones can also be obtained starting from N-alkyl/aryl benzamides, and N-C bonds are not cleaved either [58]. The mechanistic studies propose that the use of stoichiometric amount of Cu(II) salts as the key oxidant and air as the terminal oxidant are key for the regeneration of active Pd(II) species.
Catalysts 11 00620 sch015 550
Scheme 15. N-Methoxy isoquinolone formation via highly chemoselective N–H activation.
A similar catalyst system was then applied in the oxidative annulation of N-methoxybenzamides with arynes and cyclooctynes via C–H/N–H activation for the synthesis of fused isoquinolones [59]. Very recently, the annulation of benzamides with arynes using palladium with photoredox dual catalysis has also been developed for the synthesis of benzo-fused isoquinolones [60].
The formation of N-alkyl-, aryl-, or alkoxy-substituted isoquinolones by the oxidative [4 + 2] cyclocondensation of secondary benzamides with internal alkynes with selective cleavages of C–H and N–H bonds has been achieved using other transition-metal catalyst systems, such as nickel [61][62], iron [63] complexes as catalysts, and heterogeneous catalyst of palladium-nanoparticles [64], Pd/C [65][66].
In the presence of NaOPiv·H2O, Co(OAc)2·4H2O/Ag2O-catalyzed decarboxylative C–H/N–H activation/annulation of N-PyO benzamides with alkynyl carboxylic acids under air in TFE also affords 3-substituted isoquinolones with high regioselectivity [67]. Similarly, 3-substituted isoquinolones can be obtained using Co(OAc)2·4H2O as catalyst from the reactions of N-(quinolin-8-yl)benzamides with alkynylsilanes with desilylation under oxygen in the same solvent, with the use of Mn(acac)2 and CsF [68].
In addition, the first metal-free annulation of N-methoxybenzamides with internal alkynes was reported by Antonchick’s group with the use of PhI as catalyst and AcOOH as oxidant in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) at room temperature [69]. A mechanism involving the formation of hypervalent iodine reagent of (diacetoxyiodo)benzene (PIDA) is proposed. At the same time, this type of oxidative cycloaddition reaction can also occur using bis(trifluoracetoxy)iodobenzene as oxidant in the presence of trifluoroacetic acid [70].
Rh(III)-catalyzed annulation of benzoyl hydrazines and alkynes affords isoquinolones with deammoniation by cleavage of N-N bond (Scheme 10 (a)). However, [Ru(p-cymene)Cl2]2/AgSbF6-catalyzed reactions of N-(1H-pyrrolo [2,3-b]pyridin-1-yl)-benzamides with internal alkynes afford isoquinolone derivatives with remaining N-N bond untouched (Scheme 16) [71]. In this procedure, N-amino-7-azaindole is used as an efficient bidentate-directing group to promote the selective C–H bond activation.
Catalysts 11 00620 sch016 550
Scheme 16. Ruthenium-catalyzed isoquinolone formation by N-amino-7-azaindole-assisted C–H activation.
Instead of internal alkynes, the annulations of benzamides with other C2 synthons via C–H/N–H activation to construct isoquinolone ring have also been developed. For example, Glorius and coworkers developed a Rh(III)-catalyzed intermolecular [4 + 2] cyclocondensation of N-methoxybenzamides with α-halo and pseudohalo ketones to afford various 3-substituted N-methoxyisoquinolones in moderate to excellent yields (Scheme 17) [72]. The α-halo and pseudohalo ketones are utilized as oxidized alkyne equivalents to undergo the redox-neutral annulation, and through the formation of ortho-acylmethyl-benzamides as the intermediates. Recently, Ma and coworkers have also reported a Pd(OAc)2/L-alanine-catalyzed formation of 3-substituted N-(quinolin-8-yl)-isoquinolones with by N-(quinolin-8-yl)benzamides and α-bromo ketones in the presence of K2CO3 in t-AmOH [73].
Catalysts 11 00620 sch017 550
Scheme 17. 3-Substituted isoquinolone synthesis via Rh(III)-catalyzed intermolecular cyclocondensation of N-methoxybenzamides with α-halo and pseudohalo ketones.
With the use of same rhodium complex, 4-substituted isoquinolones can be obtained by a microwave-assisted annulation of N-methoxyamides with α-chloroaldehydes (Scheme 18) [74].
Catalysts 11 00620 sch018 550
Scheme 18. 4-Substituted isoquinolone formation via microwave-assisted annulation of N-methoxyamides with α-chloroaldehydes.
Moreover, 3-Cyclohexylmethyl N-methoxyisoquinolone, which was published as only one example in literature [75], can be synthesized by the cyclocondensation of N-methoxyisoquinolone with the corresponding α-carbonyl sulfoxonium ylide catalyzed by rhodium in HFIP (Scheme 19). The detailed studies for the formation of 3-substituted isoquinolones through the reactions of N-methoxybenzamides and α-carbonyl sulfoxonium ylides catalyzed by Cp*Rh(MeCN)3(SbF6)2/Zn(OTf)2 in DCE were then reported by Li and coworkers [76].
Catalysts 11 00620 sch019 550
Scheme 19. Rhodium-catalyzed cyclocondensation of N-methoxyisoquinolone with α-carbonyl sulfoxonium ylide affording 3-substituted isoquinolone.
Very recently, epoxides as alkylating reagents and C2 synthon have been applied in Pd(OAc)2-catalyzed oxidative annulation of N-alkoxybenzamides to regioselectively synthesize 3-substituted isoquinolones in HFIP solvent (Scheme 20) [77]. The present methodology has been successfully employed in the total syntheses of rupreschstyril, siamine, and cassiarin A (Figure 1).
Catalysts 11 00620 sch020 550
Scheme 20. Pd(OAc)2-catalyzed annulation of epoxides with benzamides.
Catalysts 11 00620 g001 550
Figure 1. Synthetic applications in the total synthesis of natural products.
In addition, as depicted in Scheme 3, β-keto esters can be used as a C2 synthon in the formation of isoquinolones via cyclocondensation with ortho-halobenzamides catalyzed by CuI. However, in the presence of Pd(OOCCF3)2 and K2S2O8, the reactions of N-alkoxybenzamides with β-keto esters have also been developed for the synthesis of isoquinolones via selective C–H/N–H activation [78].
Moreover, as shown in Scheme 21, in the presence of [Cp*RhCl2]2, the regioselective formation of substituted isoquinolones through cyclocondensation of N-methoxybenz-amide [79] or primary benzamides [80] with diazo compounds has also been developed. In the case of N-methoxybenzamide used, C–H/N–H activation occurs selectively.
Catalysts 11 00620 sch021 550
Scheme 21. Approach to isoquinolinones by rhodium-catalyzed annulation of benzamides with diazo compounds.
Similarly, [Cp*RhCl2]2/KOAc-catalyzed intermolecular cyclization between N-methoxybenzamide and 4-diazoisochroman-3-imines provides 3-amino-4-aryliso-quinolones via a selective N–O cleavage of 4-diazoisochroman-3-imines (Scheme 22) [81].
Catalysts 11 00620 sch022 550
Scheme 22. Rh(III)-catalyzed synthesis of highly substituted isoquinolones from 4-diazoisochroman-3-imines and N-alkoxybenzamides.
The construction of isoquinolone ring can also be realized by the annulation of carbon–carbon double bonds with benzamides with selective C–H/N–H activation.
For example, with the use of Mn(OAc)3·2H2O as the oxidant and NaOPiv·H2O as the base in TFE, Thrimurtulu and coworkers developed a Co(acac)2-catalyzed isoquinolone synthesis by the intermolecular cyclization between N-(quinolin-8-yl)benzamides and substituted allenes at room temperature to give 3-substituted N-(quinolin-8-yl)isoquino- lones [82]. In addition, in the presence of Ag2CO3 and Cs2CO3, Co(OAc)2 can catalyze the similar cyclization in the same solvent giving isoquinolones [83].
The catalysts system of [Cp*Rh(MeCN)3][SbF6]2/Cu(OAc)2 in HFIP also shows highly catalytic activity in the cyclocondensation of N-methoxybenzamides with nitroalkenes for the selective synthesis of 4-substituted N-methoxyisoquinolones [84].

3. Isoquinolone Syntheses via [5 + 1] Intermolecular Annulation between Ortho-(1-Alkynyl)Benzaldehyde and Primary Amines

Readily available ortho-(1-alkynyl)benzaldehydes have been well-applied in the synthesis of benzo-fused heterocycles [85][86][87][88][89][90][91] and carbocycles [92][93][94][95][96][97], which are also used as C5 synthon in the syntheses of isoquinolones by the intermolecular [5 + 1] cyclocondensation with primary amines.
As shown in Scheme 23, in the presence of SiO2, using an excess amount of CuBr·SMe2, the aerobic cyclocondensation of ortho-(1-alkynyl)benzaldehydes with benzyl amines or primary aliphatic amines affords 4-bromoisoquinolones [98]. Cu(OAc)2-catalyzed cyclocondensation of ortho-(1-alkynyl)benzaldehydes with aniline gives 2,3-diphenylisoquinolone in 63% yield [99].
Catalysts 11 00620 sch023 550
Scheme 23. Isoquinolone formation via [5 + 1] cyclocondensation of ortho-(1-alkynyl)-benzaldehydes with amines.
Zn(OTf)2 also shows catalytic activity for the aerobic cyclocondensation of ortho-(1-alkynyl)benzaldehydes with arylamines to give N-arylated isoquinolones [100]. The proposed mechanism involves two well-known steps of nucleophilic addition of arylamines to aldehyde, and intramolecular hydroamination followed by oxidation reaction affording isoquinolone. Zn(OTf)2 plays an important role to promote both nucleophilic addition of arylamines and intramolecular hydroamination of carbon–carbon triple bond.

4. Isoquinolone Syntheses via Other Intermolecular Annulations

A Ni(cod)2/phosphine-catalyzed denitrogenative alkyne insertion reaction of 1,2,3-benzotriazin-4(3H)-ones provides an alternatively efficient approach to substituted isoquinolones (Scheme 24) [101]. A wide-range isoquinolones can be obtained in high yields with the use of internal/terminal alkynes, including borylalkynes. This transformation can also be realized under visible-light irradiation with the assistance of a photocatalyst at room temperature [102].
Catalysts 11 00620 sch024 550
Scheme 24. Isoquinolone formation via nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones.
In addition, the similar catalyst system can also catalyze a decarbonylative addition of phthalimides to internal alkynes to afford highly substituted isoquinolones (Scheme 25) [103]. The similar transformation can take place using CoI2/phosphine/Ag2CO3 [104], and Rh(PPh3)2(CO)Cl as the catalyst systems [105].
Catalysts 11 00620 sch025 550
Scheme 25. Nickel-catalyzed decarbonylative addition of phthalimides to alkynes.
The isoquinolone skeleton can also be constructed by a Pd(OAc)2-catalyzed carbonylation/decarboxylation of diethyl(2-iodoaryl)malonates with imidoyl chlorides and CO in THF (Scheme 26) [106].
Catalysts 11 00620 sch026 550
Scheme 26. Palladium-catalyzed construction of isoquinolone ring by carbonylation/decarboxylation reaction.
The annulation reaction between benzocyclobutenols and isocyanates catalyzed by [RhOH(cod)]2 can also produce isoquinolone derivatives with excellent regioselectivity and functional-group tolerance (Scheme 27) [107]. The reactions give the first examples of formal amide fragment insertion into an aryl C–C(sp3) bond.
Catalysts 11 00620 sch027 550
Scheme 27. Rhodium(I)-catalyzed cyclocondensation of benzocyclobutenols and isocyanates affording 3-substituted isoquinolone.

References

  1. Nakamura, I.; Yamamoto, Y. Transition-metal-catalyzed reactions in heterocyclic synthesis. Chem. Rev. 2004, 104, 2127–2198.
  2. Zeni, G.; Larock, R.C. Synthesis of heterocycles via palladium π-olefin and π-alkyne Chemistry. Chem. Rev. 2004, 104, 2285–2309.
  3. Hua, R.; Abrenica, M.V.A.; Wang, P. Cycloaddition of alkynes: Atom-economic protocols for constructing six-membered cycles. Curr. Org. Chem. 2011, 15, 712–729.
  4. Gulevich, A.V.; Dudnik, A.S.; Chernyak, N.; Gevorgyan, V. Transition metal-mediated synthesis of monocyclic aromatic heterocycles. Chem. Rev. 2013, 113, 3084–3213.
  5. Nizami, T.A.; Hua, R. Cycloaddition of 1,3-butadiynes: Efficient synthesis of carbo- and heterocycles. Molecules 2014, 19, 13788–13802.
  6. Fang, G.; Bi, X. Silver-catalyzed reactions of alkynes: Recent advances. Chem. Soc. Rev. 2015, 44, 8124–8173.
  7. Huang, M.-H.; Hao, W.-J.; Li, G.; Tu, S.-J.; Jiang, B. Recent advances in radical transformations of internal alkynes. Chem. Commun. 2018, 54, 10791–10811.
  8. Zheng, L.; Hua, R. C–H activation and alkyne annulation via automatic or intrinsic directing groups: Towards high step economy. Chem. Rec. 2018, 18, 556–569.
  9. Hua, R.; Nizami, T.A. Synthesis of heterocycles by using propargyl compounds as versatile synthons. Mini Rev. Org. Chem. 2018, 15, 198–207.
  10. Zheng, L.; Hua, R. Recent advances in construction of polycyclic natural product scaffolds via one-pot reactions involving alkyne annulation. Front. Chem. 2020, 8, 580355.
  11. Strumberg, D.; Pommier, Y.; Paull, K.; Jayaraman, M.; Nagafuji, P.; Cushman, M. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons. J. Med. Chem. 1999, 42, 446–457.
  12. Glushkov, V.A.; Shklyaev, Y.V. Synthesis of 1(2H)-isoquinolones. Chem. Heterocycl. Compd. 2001, 37, 663–687.
  13. Cappelli, A.; Mohr, G.P.; Giuliani, G.; Galeazzi, S.; Anzini, M.; Mennuni, L.; Ferrari, F.; Makovec, F.; Kleinrath, E.M.; Langer, T.; et al. Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds. J. Med. Chem. 2006, 49, 6451–6464.
  14. Li, B.; Feng, H.; Wang, N.; Ma, J.; Song, H.; Xu, S.; Wang, B. Ruthenium-catalyzed oxidative coupling/cyclization of isoquinolones with alkynes through C–H/N–H activation: Mechanism study and synthesis of dibenzo[a,g]quinolizin-8-one derivatives. Chem. Eur. J. 2012, 18, 12873–12879.
  15. Cobas, A.; Guitián, E.; Castedo, L. Synthesis of 3-phenylisoquinolones by reaction of simple pyrroline-2,3-diones with benzyne. New mechanistic considerations. J. Org. Chem. 1993, 58, 3113–3117.
  16. Fisher, L.E.; Muchowski, J.M.; Clark, R.D. Heteroatom-directed metalation. Lithiation of N-propenylbenzamides and N-propenyl-o-toluamides. Novel routes to ortho-substituted primary benzamide derivatives and N-unsubstituted isoquinolin- 1(2H)-ones. J. Org. Chem. 1992, 57, 2700–2705.
  17. Davis, S.E.; Church, A.C.; Griffith, C.L.M.; Beam, C.F. The preparation of substituted 1(2H)-isoquinolinones from dilithiated 2-methyl-N-arylbenzamides, 2-methyl-N-(arylmethyl)benzamides, or 2-methylbenzoic acid, 2,2-dimethylhydrazide. Synth. Commun. 1997, 27, 2961–2969.
  18. Snow, R.J.; Butz, T.; Hammach, A.; Kapadia, S.; Morwick, T.M.; Prokopowicz, A.S., III; Takahashi, H.; Tan, J.D.; Tschantz, M.A.; Wang, X.-J. Isoquinolinone synthesis by SNAr reaction: A versatile route to imidazo[4,5-h]isoquinolin-9-ones. Tetrahedron Lett. 2002, 43, 7553–7556.
  19. Omer, H.M.; Liu, P. Computational study of the Ni-catalyzed C–H oxidative cycloaddition of aromatic amides with alkynes. ACS Omega 2019, 4, 5209–5220.
  20. Liu, C.-C.; Parthasarathy, K.; Cheng, C.-H. Synthesis of highly substituted isoquinolone derivatives by nickel-catalyzed annulation of 2-halobenzamides with alkynes. Org. Lett. 2010, 12, 3518–3521.
  21. Weng, W.-Z.; Xie, J.; Zhang, B. Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction. Org. Biomol. Chem. 2018, 16, 3983–3988.
  22. Nohira, I.; Liu, S.; Bai, R.; Lan, Y.; Chatani, N. Nickel-catalyzed C–F/N–H annulation of aromatic amides with alkynes: Activation of C–F bonds under mild reaction conditions. J. Am. Chem. Soc. 2020, 142, 17306–17311.
  23. Xie, H.; Xing, Q.; Shan, Z.; Xiao, F.; Deng, G.-J. Nickel-catalyzed annulation of o-haloarylamidines with aryl acetylenes: Synthesis of isoquinolone and 1-aminoisoquinoline Derivatives. Adv. Synth. Catal. 2019, 361, 1896–1901.
  24. Wang, F.; Liu, H.; Fu, H.; Jiang, Y.; Zhao, Y. An efficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-one derivatives. Org. Lett. 2009, 11, 2469–2472.
  25. Thansandote, P.; Hulcoop, D.G.; Langer, M.; Lautens, M. Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: A route to functionalized indolines, isoquinolinones, and indoles. J. Org. Chem. 2009, 74, 1673–1678.
  26. Liu, Y.; Zeng, R.; Pan, J.; Zou, J. Copper(II)-catalyzed synthesis of N-substituted-3-amino-4-cyano-isoquinoline-1(2H)-ones by the reaction of N-substituted-2-iodobenzamides with malononitrile. Chin. J. Chem. 2014, 32, 883–888.
  27. Shi, Y.; Zhu, X.; Mao, H.; Hu, H.; Zhu, C.; Cheng, Y. Synthesis of functionalized isoquinolin-1(2H)-ones by copper-catalyzed α-arylation of ketones with 2-halobenzamides. Chem. Eur. J. 2013, 19, 11553–11557.
  28. Mayo, M.S.; Yu, X.; Feng, X.; Yamamoto, Y.; Bao, M. Isoquinolone synthesis through SNAr reaction of 2-halobenzonitriles with ketones followed by cyclization. J. Org. Chem. 2015, 80, 3998–4002.
  29. Guimond, N.; Gouliaras, C.; Fagnou, K. Rhodium(III)-catalyzed isoquinolone synthesis: The N–O bond as a handle for C-N bond formation and catalyst turnover. J. Am. Chem. Soc. 2010, 132, 6908–6909.
  30. Guimond, N.; Gorelsky, S.I.; Fagnou, K. Rhodium(III)-catalyzed heterocycle synthesis using an internal oxidant: Improved reactivity and mechanistic studies. J. Am. Chem. Soc. 2011, 133, 6449–6457.
  31. Xu, X.; Liu, Y.; Park, C.-M. Rhodium(III)-catalyzed intramolecular annulation through C–H activation: Total synthesis of (±)-Antofine, (±)-Septicine, (±)-Tylophorine, and Rosettacin. Angew. Chem. Int. Ed. 2012, 51, 9372–9376.
  32. Webb, N.J.; Marsden, S.P.; Raw, S.A. Rhodium(III)-catalyzed C–H activation/annulation with vinyl esters as an acetylene equivalent. Org. Lett. 2014, 16, 4718–4721.
  33. Hyster, T.K.; Rovis, T. Rhodium(III)-catalyzed C–H activation mediated synthesis of isoquinolones from amides and cyclopropenes. Synlett 2013, 24, 1842–1844.
  34. Wang, H.; Glorius, F. Mild rhodium(III)-catalyzed C–H activation and intermolecular annulation with allenes. Angew. Chem. Int. Ed. 2012, 51, 7318–7322.
  35. Sun, R.; Yang, X.; Li, Q.; Xu, K.; Tang, J.; Zheng, X.; Yuan, M.; Fu, H.; Li, R.; Chen, H. Divergent synthesis of isoquinolone and isocoumarin derivatives by the annulation of benzoic acid with N-vinyl amide. Org. Lett. 2019, 21, 9425–9429.
  36. Coles-Taylor, B.L.; McCallum, M.S.; Lee, J.S.; Michel, B.W. Accessing 4-oxy-substituted isoquinolinones via C–H activation and regioselective migratory insertion with electronically biased ynol ethers. Org. Biomol. Chem. 2018, 16, 8639–8646.
  37. Li, B.; Feng, H.; Xu, S.; Wang, B. Ruthenium-catalyzed isoquinolone synthesis through C–H activation using an oxidizing directing group. Chem. Eur. J. 2011, 17, 12573–12577.
  38. Guntreddi, T.; Shankar, M.; Kommu, N.; Sahoo, A.K. Construction of pyranoisoquinolines via Ru(II)-catalyzed unsymmetrical double annulation of N-methoxybenzamides with unactivated alkynes. J. Org. Chem. 2019, 84, 13033–13044.
  39. Ackermann, L.; Fenner, S. Ruthenium-catalyzed C–H/N–O bond functionalization: Green isoquinolone syntheses in water. Org. Lett. 2011, 13, 6548–6551.
  40. Krieger, J.-P.; Ricci, G.; Lesuisse, D.; Meyer, C.; Cossy, J. Harnessing C–H activation of benzhydroxamates as a macrocyclization strategy: Synthesis of structurally diverse macrocyclic isoquinolones. Chem. Eur. J. 2016, 22, 13469–13473.
  41. Yang, J.; Wu, L.; Xu, H.; Gao, H.; Zhou, Z.; Yi, W. Redox-neutral [4 + 2] annulation of N-methoxybenzamides with alkynes enabled by an osmium(II)/HOAc catalytic system. Org. Lett. 2019, 21, 9904–9908.
  42. Liu, M.; Niu, J.-L.; Yang, D.; Song, M.-P. Development of a traceless directing group: Cp*-free cobalt-catalyzed C–H activation/annulations to access isoquinolinones. J. Org. Chem. 2020, 85, 4067–4078.
  43. Huang, H.; Nakanowatari, S.; Ackermann, L. Selectivity control in ruthenium(II)-catalyzed C–H/N–O activation with alkynyl bromides. Org. Lett. 2017, 19, 4620–4623.
  44. Song, L.; Zhang, X.; Tang, X.; Van Meervelt, L.; Van der Eycken, J.; Harvey, J.N.; Van der Eycken, E.V. Ruthenium-catalyzed cascade C–H activation/annulation of N-alkoxybenzamides: Reaction development and mechanistic insight. Chem. Sci. 2020, 11, 11562–11569.
  45. Yu, B.; Chen, Y.; Hong, M.; Duan, P.; Gan, S.; Chao, H.; Zhao, Z.; Zhao, J. Rhodium-catalyzed C–H activation of hydrazines leads to isoquinolones with tunable aggregation-induced emission properties. Chem. Commun. 2015, 51, 14365–14368.
  46. Zhu, H.; Zhuang, R.; Zheng, W.; Fu, L.; Zhao, Y.; Tu, L.; Chai, Y.; Zeng, L.; Zhang, C.; Zhang, J. Synthesis of isoquinolone via rhodium(III)-catalyzed C–H activation with 1,4,2-dioxazol-5-ones as oxidizing directing group. Tetrahedron 2019, 75, 3108–3112.
  47. Li, X.; Zhang, R.; Qi, Y.; Zhao, Q.; Yao, T. Rhodium(III)-catalyzed C–H activation/annulation of N-iminopyridinium ylides with alkynes and diazo compounds. Org. Chem. Front. 2021, 8, 1190–1196.
  48. Yang, Z.; Jie, L.; Yao, Z.; Yang, Z.; Cui, X. Rhodium (III)-catalyzed synthesis of N-(2-acetoxyalkyl)isoquinolones from oxazolines and alkynes through C-N bond formation and ring-opening. Adv. Synth. Catal. 2019, 361, 214–218.
  49. Yu, X.; Chen, K.; Guo, S.; Shi, P.; Song, C.; Zhu, J. Direct access to cobaltacycles via C–H activation: N-Chloroamide-enabled room-temperature synthesis of heterocycles. Org. Lett. 2017, 19, 5348–5351.
  50. Mochida, S.; Umeda, N.; Hirano, K.; Satoh, T.; Miura, M. Rhodium-catalyzed oxidative coupling/cyclization of benzamides with alkynes via C–H bond cleavage. Chem. Lett. 2010, 39, 744–746.
  51. Hyster, T.K.; Rovis, T. Rhodium-catalyzed oxidative cycloaddition of benzamides and alkynes via C–H/N–H activation. J. Am. Chem. Soc. 2010, 132, 10565–10569.
  52. Song, G.; Chen, D.; Pan, C.-L.; Crabtree, R.H.; Li, X. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: Synthesis of polycyclic amides. J. Org. Chem. 2010, 75, 7487–7490.
  53. Upadhyay, N.S.; Thorat, V.H.; Sato, R.; Annamalai, P.; Chuang, S.-C.; Cheng, C.-H. Synthesis of isoquinolones via Rh-catalyzed C–H activation of substituted benzamides using air as the sole oxidant in water. Green Chem. 2017, 19, 3219–3224.
  54. Ackermann, L.; Lygin, A.V.; Hofmann, N. Ruthenium-catalyzed oxidative annulation by cleavage of C–H/N–H bonds. Angew. Chem. Int. Ed. 2011, 50, 6379–6382.
  55. Allu, S.; Swamy, K.C.K. Ruthenium-catalyzed synthesis of isoquinolones with 8-aminoquinoline as a bidentate directing group in C–H functionalization. J. Org. Chem. 2014, 79, 3963–3972.
  56. Zhong, H.; Yang, D.; Wang, S.; Huang, J. Pd-catalyzed synthesis of isoquinolinones and analogues via C–H and N–H bonds double activation. Chem. Commun. 2012, 48, 3236–3238.
  57. Lu, S.; Lin, Y.; Zhong, H.; Zhao, K.; Huang, J. A practical one-pot procedure for the synthesis of N–H isoquinolones. Tetrahedron Lett. 2013, 54, 2001–2005.
  58. Zhang, N.; Li, B.; Zhong, H.; Huang, J. Synthesis of N-alkyl and N-aryl isoquinolones and derivatives via Pd-catalyzed C–H activation and cyclization reactions. Org. Biomol. Chem. 2012, 10, 9429–9439.
  59. Peng, X.; Wang, W.; Jiang, C.; Sun, D.; Xu, Z.; Tung, C.-H. Strain-promoted oxidative annulation of arynes and cyclooctynes with benzamides: Palladium-catalyzed C–H/N–H activation for the synthesis of N-heterocycles. Org. Lett. 2014, 16, 5354–5357.
  60. Zhao, J.; Li, H.; Li, P.; Wang, L. Annulation of benzamides with arynes using palladium with photoredox dual catalysis. J. Org. Chem. 2019, 84, 9007–9016.
  61. Shiota, H.; Ano, Y.; Aihara, Y.; Fukumoto, Y.; Chatani, N. Nickel-catalyzed chelation-assisted transformations involving ortho- C–H bond activation: Regioselective oxidative cycloaddition of aromatic amides to alkynes. J. Am. Chem. Soc. 2011, 133, 14952–14955.
  62. Obata, A.; Ano, Y.; Chatani, N. Nickel-catalyzed C–H/N–H annulation of aromatic amides with alkynes in the absence of a specific chelation system. Chem. Sci. 2017, 8, 6650–6655.
  63. Matsubara, T.; Ilies, L.; Nakamura, E. Oxidative C–H activation approach to pyridone and isoquinolone through an iron-catalyzed coupling of amides with alkynes. Chem. Asian J. 2016, 11, 380–384.
  64. Sharma, N.; Saha, R.; Parveen, N.; Sekar, G. Palladium-nanoparticles-catalyzed oxidative annulation of benzamides with alkynes for the synthesis of isoquinolones. Adv. Synth. Catal. 2017, 359, 1947–1958.
  65. Shu, Z.; Li, W.; Wang, B. Pd/C-catalyzed synthesis of isoquinolones through C–H activation. ChemCatChem 2015, 7, 605–608.
  66. Shu, Z.; Guo, Y.; Li, W.; Wang, B. Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C–H/N–H activation. Catal. Today 2017, 297, 292–297.
  67. Hao, X.-Q.; Du, C.; Zhu, X.; Li, P.-X.; Zhang, J.-H.; Niu, J.-L.; Song, M.-P. Cobalt(II)-catalyzed decarboxylative C–H activation/annulations cascades: Regioselective access to isoquinolones and isoindolinones. Org. Lett. 2016, 18, 3610–3613.
  68. Lin, C.; Shen, L. Co-catalyzed ortho-C–H functionalization/annulation of arenes and alkenes with alkynylsilanes: Access to isoquinolone and pyridine motifs. RSC Adv. 2019, 9, 30650–30654.
  69. Manna, S.; Antonchick, A.P. Organocatalytic oxidative annulation of benzamide derivatives with alkynes. Angew. Chem. Int. Ed. 2014, 53, 7324–7327.
  70. Chen, Z.-W.; Zhu, Y.-Z.; Ou, J.-W.; Wang, Y.-P.; Zheng, J.-Y. Metal-free iodine(III)-promoted synthesis of isoquinolones. J. Org. Chem. 2014, 79, 10988–10998.
  71. Sagara, P.S.; Siril, P.F.; Ravikumar, P.C. N-Amino-7-azaindole as the N,N’-bidentate directing group: Ruthenium-catalyzed oxidative annulation of N-(7-azaindole)benzamides with alkynes via C–H bond activation. J. Org. Chem. 2019, 84, 12314–12323.
  72. Yu, D.-G.; de Azambuja, F.; Glorius, F. α-MsO/TsO/Cl Ketones as oxidized alkyne equivalents: Redox-neutral rhodium(III)-catalyzed C–H activation for the synthesis of N-heterocycles. Angew. Chem. Int. Ed. 2014, 53, 2754–2758.
  73. Xie, C.; Dai, Z.; Niu, Y.; Ma, C. Cascade one-pot method to synthesize isoquinolin-1(2H)-ones with α-bromo ketones and benzamides via Pd-catalyzed C–H activation. J. Org. Chem. 2018, 83, 2317–2323.
  74. Huang, J.-R.; Bolm, C. Microwave-assisted synthesis of heterocycles by rhodium(III)-catalyzed annulation of N-methoxyamides with α-chloroaldehydes. Angew. Chem. Int. Ed. 2017, 56, 15921–15925.
  75. Barday, M.; Janot, C.; Halcovitch, N.R.; Muir, J.; Aïssa, C. Cross-coupling of α-carbonyl sulfoxonium ylides with C–H bonds. Angew. Chem. Int. Ed. 2017, 56, 1311–13121.
  76. Xu, Y.; Zheng, G.; Yang, X.; Li, X. Rhodium(III)-catalyzed chemodivergent annulations between N-methoxybenzamides and sulfoxonium ylides via C–H activation. Chem. Commun. 2018, 54, 670–673.
  77. Wang, H.; Cao, F.; Gao, W.; Wang, X.; Yang, Y.; Shi, T.; Wang, Z. Pd(II)-catalyzed annulation reactions of epoxides with benzamides to synthesize isoquinolones. Org. Lett. 2021, 23, 863–868.
  78. Xu, G.-D.; Huang, Z.-Z. A cascade dehydrogenative cross-coupling/annulation reaction of benzamides with β-keto esters for the synthesis of isoquinolinone derivatives. Org. Lett. 2017, 19, 6265–6267.
  79. Shi, L.; Yu, K.; Wang, B. Regioselective synthesis of multisubstituted isoquinolones and pyridones via Rh(III)-catalyzed annulation reactions. Chem. Commun. 2015, 51, 17277–17280.
  80. Wu, Y.; Sun, P.; Zhang, K.; Yang, T.; Yao, H.; Lin, A. Rh(III)-catalyzed redox-neutral annulation of primary benzamides with diazo compounds: Approach to isoquinolinones. J. Org. Chem. 2016, 81, 2166–2173.
  81. Li, Z.; Wu, L.; Chang, B.; Lu, P.; Wang, Y. Rh(III)-catalyzed synthesis of 3-amino-4-arylisoquinolinones from 4-diazoisochroman-3-imines and N-methoxybenzamides. Org. Lett. 2019, 21, 1497–1501.
  82. Thrimurtulu, N.; Dey, A.; Maiti, D.; Volla, C.M.R. Cobalt-catalyzed sp2-C–H activation: Intermolecular heterocyclization with allenes at room temperature. Angew. Chem. Int. Ed. 2016, 55, 12361–12365.
  83. Boobalan, R.; Kuppusamy, R.; Santhoshkumar, R.; Gandeepan, P.; Cheng, C.-H. Access to isoquinolin-1(2H)-ones and pyridones by cobalt-catalyzed oxidative annulation of amides with allenes. ChemCatChem 2017, 9, 273–277.
  84. Potter, T.J.; Li, Y.; Ward, M.D.; Ellman, J.A. Rh(III)-catalyzed synthesis of isoquinolones and 2-pyridones by annulation of N-methoxyamides and nitroalkenes. Eur. J. Org. Chem. 2018, 4381–4388.
  85. Yao, X.; Li, C.-J. Water-triggered and gold(I)-catalyzed cascade addition/cyclization of terminal alkynes with ortho-alkynylaryl aldehyde. Org. Lett. 2006, 8, 1953–1955.
  86. Ju, J.; Hua, R. Copper-catalyzed synthesis of isoquinolines by the cyclocondensation of ortho-alkynyl aromatic aldehydes or ketones with urea. Curr. Org. Synth. 2013, 10, 328–332.
  87. Dell’Acqua, M.; Castano, B.; Cecchini, C.; Pedrazzini, T.; Pirovano, V.; Rossi, E.; Caselli, A.; Abbiati, G. Mild regiospecific synthesis of 1-alkoxy-isochromenes catalyzed by well-defined [silver(I)(pyridine-containing ligand)] complexes. J. Org. Chem. 2014, 79, 3494–3505.
  88. Jiang, B.; Zhou, Y.; Kong, Q.; Jiang, H.; Liu, H.; Li, J. “One-pot” synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a]isoquinolines via a silver(I)-catalyzed cascade approach. Molecules 2013, 18, 814–831.
  89. Mariaule, G.; Newsome, G.; Toullec, P.Y.; Belmont, P.; Michelet, V. Silver-catalyzed domino hydroarylation/cycloisomerization reactions of ortho-alkynylbenzaldehydes: An entry to functionalized isochromene derivatives. Org. Lett. 2014, 16, 4570–4573.
  90. Xiao, T.; Peng, P.; Xie, Y.; Wang, Z.-y.; Zhou, L. Ag(I)-catalyzed three-component reaction of 2-alkynylbenzaldehydes, amines, and diazo compounds. Org. Lett. 2015, 17, 4332–4335.
  91. Liu, H.; Lu, L.; Hua, R. [Cu(maloNHC)]-catalyzed synthesis of 2-aryl pyrazolo[5,1-a]isoquinolines by annulation of N’-(2-((trimethylsilyl)ethynyl)benzylidene)hydrazides with terminal aromatic alkynes. Tetrahedron 2017, 73, 6428–6435.
  92. Zhao, X.; Zhang, G.-X.; Tang, R.-Y.; Deng, C.-L.; Li, J.-H. ZnI2-catalyzed benzannulation of o-alkynylbenzaldehydes with alkenes leading to 1-acyl-2-substituted naphthalenes. Eur. J. Org. Chem. 2010, 4211–4217.
  93. Malhotra, D.; Liu, L.-P.; Mashuta, M.S.; Hammond, G.B. Gold-catalyzed annulations of 2-alkynyl benzaldehydes with vinyl ethers: Synthesis of dihydronaphthalene, isochromene, and bicyclo [2.2.2]octane derivatives. Chem. Eur. J. 2013, 19, 4043–4050.
  94. Sakthivel, K.; Srinivasan, K. Indium(III) triflate-catalysed [4 + 2] benzannulation reactions of o-alkynylbenzaldehydes with enolisable carbonyl compounds: Selective synthesis of naphthyl ketones. Org. Biomol. Chem. 2014, 12, 269–277.
  95. Manojveer, S.; Balamurugan, R. A facile access to substituted benzo[a]fluorenes from o-alkynylbenzaldehydes via in situ formed acetals. Chem. Commun. 2014, 50, 9925–9928.
  96. Manojveer, S.; Balamurugan, R. A cascade approach to naphthalene derivatives from o-alkynylbenzaldehydes and enolizable ketones via in-situ-formed acetals. Eur. J. Org. Chem. 2015, 4254–4260.
  97. Guo, B.; Zhou, Y.; Zhang, L.; Hua, R. Brønsted acid-promoted one-pot synthesis of chrysene derivatives via isochromenylium intermediate formed in situ. J. Org. Chem. 2015, 80, 7635–7641.
  98. Too, P.C.; Chiba, S. A CuBr-mediated aerobic reaction of 2-alkynylbenzaldehydes and primary amines: Synthesis of 4-bromoisoquinolones. Chem. Commun. 2012, 48, 7634–7636.
  99. Zhang, M.; Zhang, H.-J.; Ruan, W.; Wen, T.-B. Construction of isoquinolin-(2H)-ones by copper-catalyzed tandem reactions of 2-(1-alkynyl)benzaldimines with water. Eur. J. Org. Chem. 2015, 2015, 5914–5918.
  100. Khan, D.M.; Hua, R. Isoquinolone synthesis via Zn(OTf)2-catalyzed aerobic cyclocondensation of 2-(1-alkynyl)benzaldehydes with arylamines. Catalysts 2020, 10, 683.
  101. Miura, T.; Yamauchi, M.; Murakami, M. Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones. Org. Lett. 2008, 10, 3085–3088.
  102. Wang, H.; Yu, S. Synthesis of isoquinolones using visible-light-promoted denitrogenative alkyne insertion of 1,2,3-benzotriazinones. Org. Lett. 2015, 17, 4272–4275.
  103. Kajita, Y.; Matsubara, S.; Kurahashi, T. Nickel-catalyzed decarbonylative addition of phthalimides to alkynes. J. Am. Chem. Soc. 2008, 130, 6058–6059.
  104. Min, X.-T.; Ji, D.-W.; Zheng, H.; Chen, B.-Z.; Hu, Y.-C.; Wan, B.; Chen, Q.-A. Cobalt-catalyzed regioselective carboamidation of alkynes with imides enabled by cleavage of C–N and C–C bonds. Org. Lett. 2020, 22, 3386–3391.
  105. Xu, F.; Zhu, W.-J.; Wang, J.; Ma, Q.; Shen, L.-J. Rhodium-catalyzed synthesis of substituted isoquinolones via a selective decarbonylation/alkyne insertion cascade of phthalimides. Org. Biomol. Chem. 2020, 18, 8219–8223.
  106. Zheng, Z.; Alper, H. Palladium-catalyzed carbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with imidoyl Chlorides: An efficient route to substituted isoquinolin-1(2H)-ones. Org. Lett. 2008, 10, 4903–4906.
  107. He, Y.; Yuan, C.; Jiang, Z.; Shuai, L.; Xiao, Q. Expeditious synthesis of isoquinolone derivatives by rhodium(I)-catalyzed annulation reaction through C–C bond cleavage. Org. Lett. 2019, 21, 185–189.
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Ruimao Hua
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