Krill (Euphausia superba) is a small marine crustacean from the Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for most fish. It is a known source of highly bioavailable omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In preclinical studies, krill oil showed metabolic, anti-inflammatory, neuroprotective and chemo preventive effects, while in clinical trials it showed significant metabolic, vascular and ergogenic actions. Solvent extraction is the most conventional method to obtain krill oil. However, different solvents must be used to extract all lipids from krill because of the diversity of the polarities of the lipid compounds in the biomass.
2. Highly Active Omega-3 Fatty Acids from Krill Oil
The entry is from 10.3390/md19060306
- Nicol, S.; Endo, Y. Krill fisheries: Development, management and ecosystem implications. Aquat. Living Resour. 1999, 12, 105–120.
- Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). Krill Fisheries and Sustainability. Available online: (accessed on 23 May 2021).
- Nicol, S.; Foster, J.; Kawaguchi, S. The fishery for Antarctic krill—Recent developments. Fish Fish. 2011, 13, 30–40.
- Cicero, A.F.; Colletti, A. Krill oil: Evidence of a new source of polyunsaturated fatty acids with high bioavailability. Clin. Lipidol. 2015, 10, 1–4.
- Grantham, G.J. The Southern Ocean: The Utilization of Krill; Southern Ocean Fisheries Survey Programme GLO/SO/7/3; Food and Agriculture Organization: Rome, Italy, 1977; pp. 1–61.
- Ramprasath, V.R.; Eyal, I.; Zchut, S.; Jones, P.J. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. Lipids Health Dis. 2013, 12, 178.
- Cicero, A.F.G.; Ertek, S.; Borghi, C. Omega-3 polyunsaturated fatty acids: Their potential role in blood pressure prevention and management. Curr. Vasc. Pharmacol. 2009, 7, 330–337.
- Cicero, A.F.G.; De Sando, V.; Parini, A.; Borghi, C. Polyunsaturated fatty acids application in internal medicine: Beyond the established cardiovascular effects. Arch. Med. Sci. 2012, 8, 784–793.
- Zheng, J.-S.; Hu, X.-J.; Zhao, Y.-M.; Yang, J.; Li, D. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: Meta-analysis of data from 21 independent prospective cohort studies. BMJ 2013, 346, f3706.
- Saravanan, P.; Davidson, N.C.; Schmidt, E.B.; Calder, P. Cardiovascular effects of marine omega-3 fatty acids. Lancet 2010, 376, 540–550.
- Laslett, L.L.; Antony, B.; Wluka, A.E.; Hill, C.; March, L.; Keen, H.I.; Otahal, P.; Cicuttini, F.M.; Jones, G. KARAOKE: Krill oil versus placebo in the treatment of knee osteoarthritis: Protocol for a randomised controlled trial. Trials 2020, 21, 1–14.
- Ulven, S.M.; Kirkhus, B.; Lamglait, A.; Basu, S.; Elind, E.; Haider, T.; Berge, K.; Vik, H.; Pedersen, J.I. Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers. Lipids 2010, 46, 37–46.
- Kim, M.G.; Yang, I.; Lee, H.S.; Lee, J.-Y.; Kim, K. Lipid-modifying effects of krill oil vs fish oil: A network meta-analysis. Nutr. Rev. 2020, 78, 699–708.
- Cicero, A.F.G.; Morbini, M.; Borghi, C. Do we need ’new’ omega-3 polyunsaturated fatty acids formulations? Expert Opin. Pharmacother. 2015, 16, 285–288.
- Kwantes, J.M.; Grundmann, O. A Brief Review of Krill Oil History, Research, and the Commercial Market. J. Diet. Suppl. 2014, 12, 23–35.
- Harris, W.S.; Miller, M.; Tighe, A.P.; Davidson, M.H.; Schaefer, E.J. Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanistic perspectives. Atherosclerosis 2008, 197, 12–24.
- Wang, L.; Yang, F.; Rong, Y.; Yuan, Y.; Ding, Y.; Shi, W.; Wang, Z. Effects of different proteases enzymatic extraction on the lipid yield and quality of Antarctic krill oil. Food Sci. Nutr. 2019, 7, 2224–2230.
- Alvarez-Ricartes, N.; Oliveros-Matus, P.; Mendoza, C.; Perez-Urrutia, N.; Echeverria, F.; Iarkov, A.; Barreto, G.E.; Echeverria, V. Correction to: Intranasal Cotinine Plus Krill Oil Facilitates Fear Extinction, Decreases Depressive-Like Behavior, and Increases Hippocampal Calcineurin a Levels in Mice. Mol. Neurobiol. 2018, 55, 7961.
- Suzuki, Y.; Fukushima, M.; Sakuraba, K.; Sawaki, K.; Sekigawa, K. Krill Oil Improves Mild Knee Joint Pain: A Randomized Control Trial. PLoS ONE 2016, 11, e0162769.
- Van Der Wurff, I.S.; Von Schacky, C.; Bergeland, T.; Leontjevas, R.; Zeegers, M.P.; Jolles, J.; Kirschner, P.A.; De Groot, R.H. Effect of 1 Year Krill Oil Supplementation on Cognitive Achievement of Dutch Adolescents: A Double-Blind Randomized Controlled Trial. Nutrients 2019, 11, 1230.
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